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Combined nitric oxide-releasing poly(vinyl alcohol) film/F127 hydrogel for accelerating wound healing
No full textNitric oxide (NO) releasing biomaterials represent a potential strategy for use as active wound dressings capable of accelerating wound healing. Topical NO-releasing poly(vinyl alcohol) (PVA) films and Pluronic F127 hydrogels (F127) have already exhibited effective skin vasodilation and wound healing actions. In this study, we functionalized PVA films with SNO groups via esterification with a mixture of mercaptosucinic acid (MSA) and thiolactic acid (TLA) followed by S-nitrosation of the -SH moieties. These films were combined with an underlying layer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), i.e., PEO-PPO-PEO (Pluronic F127) hydrogel and used for the topical treatment of skin lesions in an animal model. The mixed esterification of PVA with MSA and TLA led to chemically crosslinked PVA-SNO films with a high swelling capacity capable of spontaneously releasing NO. Real time NO-release measurements revealed that the hydrogel layer reduces the initial NO burst from the PVA-SNO films. We demonstrate that the combination of PVA-SNO films with F127 hydrogel accelerates wound contraction, decreases wound gap and cellular density and accelerates the inflammatory phase of the lesion. These results were reflected in an increase in myofibroblastic differentiation and collagen type III expression in the cicatricial tissue. Therefore, PVA-SNO films combined with F127 hydrogel may represent a new approach for active wound dressings capable of accelerating wound healing130182191CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO CARLOS CHAGAS FILHO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIRO - FAPERJFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP131917/2013-7; 309390/2011-7; 302918/2012-7E-26/102.918/20112013/21936-4; 2008/57560-
Monitoring of multiple solid-state transformations at tablet surfaces using multi-series near-infrared hyperspectral imaging and multivariate curve resolution
No full textThe assessment of the solid-state stability of active pharmaceutical ingredient (API) and/or excipients in solid dosage forms during manufacturing and storage is mandatory for safeguarding quality of the final products. In this work, the solid-state transformations in tablets prepared as blends of piroxicam monohydrate, polyvinylpyrrolidone and the lactose forms monohydrate or anhydrate were studied when the tablets were exposed to the 23-120 degrees C range. Multi-series near-infrared hyperspectral images were obtained from the surface of each sample for unveiling the local evolution of the solid-state transformations. The preprocessed spectra from the images (dataset) were arranged in augmented matrices, according to the composition of the tablets, and the profile of the overlapped compounds (relative concentration) along the solid-state transformations in the pixels was resolved by using multivariate curve resolution alternating least squares (MCR-ALS). Therefore, the dehydration of piroxicam and lactose monohydrates could be mapped separately in the samples (explained variances by the models >96%) even when both compounds were being transformed simultaneously (80-120 degrees C). The images reproduced the same trends obtained from thermogravimetric analysis of the tablets, with the advantage that the pixel-to-pixel heterogeneity of each compound at the surface of the tablets was highlighted93224230CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPE
On existence and scattering theory for the klein-gordon-schrodinger system in an infinite -norm setting
No full textThis paper is concerned with the initial value problem for the nonlinear Klein-Gordon-Schrodinger (KGS) system in . We consider general polynomial nonlinearities that include in particular the classical Yukawa-KGS model. We show existence of local and global mild solutions for the KGS system with initial data in weak -spaces, which is an infinite -norm setting. Moreover, we obtain a persistence result in when the initial data belong to this class, which shows that the constructed data-solution map in weak- recovers -regularity. We also prove results of scattering and wave operators in that singular framework1943781804CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPES
A comparative study on image quality of two digital intraoral sensors—methodological, ethical and statistical issues
No full textNão tem49
Collective health from the founders’ perspective: room for convergence and heterogeneity
No full textsem informação36
Rehabilitation of atrophic anophthalmic cavity with orthostatic ocular prosthesis: a clinical report
No full textThe absence of the eyeball can generate psychosocial and facial harmony changes, such as atrophy of the muscles around it. In these cases, the use of an orthostatic prosthesis with expanding function fosters distension of the tissues for subsequent rehabilitation. This technique consists of making individual ocular prostheses with gradual enlargement of size. The aim of this following clinical report was to describe the technique used in the standing prosthetic rehabilitation of a patient, 73 years old, who underwent enucleation of the right eye as a result of glaucoma. Clinical and laboratory procedures were performed such as impression, adjusting curvature of the sclera, centering the pupil area and processing in heat-cured acrylic resin three prostheses made according to the expansion of the anophthalmic cavity. At the end of treatment, there was a considerable increase of the cavity, allowing for volume replacement similar to that existing in the patient’s contralateral orbit, thus generating a satisfactory facial harmony.39539739
Home management of INR in the public health system: feasibility of self-management of oral anticoagulation and long-term performance of individual POC devices in determining INR
No full textThe home prothrombin time/international normalized ratio (PT/INR) self-management could be convenient for patients, enhancing treatment compliance and improving the quality of the oral anticoagulation. However, patient self-management (PSM) of oral anticoagulation may not be feasible for up to half of the patients due to cognitive or educational issues. In the present study, we aimed to evaluate the feasibility of a PSM program in a public health medical center that provides care for low-income patients. We also aimed to determine the accuracy of individual point-of-care devices (CoaguChek XS®) during long-term of home manipulation. Patients’ time-in-therapeutic range (TTR) and perception of quality of life, were evaluated at scheduled study-visits to the center. Additionally, the accuracy of individual CoaguChek XS® was evaluated in comparison to the standard automated coagulometer at scheduled study-visits to the center. Twenty-five patients were included in the PSM program. The median TTR of patients was 75 % before inclusion, 72 % at 3 months, 75 % at 6 months and 100 % at 12 months after the beginning of self-management (P = 0.14).The median DASS scores were 64, 63, 61.5 and 71.5 before inclusion and at 3, 6 and 12 months, respectively (P = 0.09). One hundred paired INR values were obtained. Correlation between INR values delivered by individual CoaguChek XS® and the automated coagulometer was 94 % and the mean result bias was 0.07 INR units. The coefficient of correlation and the mean bias between methods was stable during 24 months of follow-up. The present study suggests that PSM is feasible for patients treated in the public health system and that the results delivered by CoaguChek XS® have long-term reliability.4214615
The role of infection and sepsis in the brazilian network for surveillance of severe maternal morbidity
No full textTo identify the burden of severe infection within the Brazilian Network for Surveillance of Severe Maternal Morbidity and factors associated with worse maternal outcomes. This was a multicentre cross‐sectional study involving 27 referral maternity hospitals in Brazil. WHO′s standardised criteria for potentially life‐threatening conditions and maternal near miss were used to identify cases through prospective surveillance and the main cause of morbidity was identified as infection or other causes (hypertension, haemorrhage or clinical/surgical). Complications due to infection were compared to complications due to the remaining causes of morbidity. Factors associated with a severe maternal outcome were assessed for the cases of infection. A total of 502 (5.3%) cases of maternal morbidity were associated with severe infection vs. 9053 cases (94.7%) with other causes. Considering increased severity of cases, infection was responsible for one‐fourth of all maternal near miss (23.6%) and nearly half (46.4%) of maternal deaths, with a maternal near miss to maternal death ratio three times (2.8:1) that of cases without infection (7.8:1) and a high mortality index (26.3%). Within cases of infection, substandard care was present in over one half of the severe maternal outcome cases. Factors independently associated with worse maternal outcomes were HIV/AIDS, hysterectomy, prolonged hospitalisation, intensive care admission and delays in medical care. Infection is an alarming cause of maternal morbidity and mortality and timely diagnosis and adequate management are key to improving outcomes during pregnancy. Delays should be addressed, risk factors identified, and specific protocols of surveillance and care developed for use during pregnancy.21218319
Comparative analysis of root dentin morphology and structure of human versus bovine primary teeth
No full textThis study evaluated the structural and morphological differences between human and bovine primary root canals. Primary human maxillary central incisors (H) (n = 9) and primary bovine incisors (B) (n = 9) were selected. The roots were sectioned in the vestibular-lingual direction, planed and delimited in cervical, middle, and apical thirds. Tubule density (number of tubules per mm(2)) and diameter were analyzed by scanning electron microscopy (1,000 and 5,000x) using Image J 1.47 software. Data were submitted to two-way repeated measures ANOVA and Tukey tests (alpha = 0.05). The highest tubule density was observed for B (28.527 +/- 1.717 mm(2)) compared with H (15.931 +/- 0.170 mm2) (p<0.01). Regarding root thirds, the cervical third presented a greater tubule density (26.417 +/- 11.654 mm(2)) than the apical third (17.999 +/- 5.873 mm(2)). The diameter of the dentin tubules was not different for cervical (3.50 +/- 0.08 mu m), middle (3.45 +/- 0.30 mu m) and apical thirds (3.42 +/- 0.33 mu m) and substrate (H-3.29 +/- 0.14 mu m; B-3.63 +/- 0.06 mu m). It could be concluded that: (1) the radicular dentin structure of human and bovine primary teeth and root thirds differ in terms of the tubule density; (2) the radicular dentin morphology of human and bovine primary teeth and root thirds are similar in terms of the diameter of the dentin tubules213689694FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP2013/06492-
Variação dos monoisomeros e diisomeros do acido cafeoilquinico com maturação de cafe
No full textOrientador: Morris W.MontgomeryDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de AlimentosResumo: O objetivo principal desta pesquisa foi verificar a existência ou não de uma variação da relação entre os monoisômeros e os diisômeros do ácido dicafeoil químico durante a maturação de café, uma vez que uma variação deste tipo poderia afetar diretamente a qualidade da bebida. As analises foram feitas em cafés arábicas cv Catuai vermelho preparados tanto por via úmida como por via seca. Foi demonstrada uma alta significância entre a relação % monoisômero; 3% diisômero com a maturação desde o estágio verde a grão passa. Os resultados indicam que a inclusão de grãos parcialmente verdes prejudicaria o sabor da bebida por estes grãos apresentarem relações inferiores aos demais. Os altos teores nos grãos verdes, estagio em que a qualidade é comprovadamente baixa, indicais que neste estágio, outros fatores estafo em maior relevância. Foi demonstrado também que as vias de preparo influíram significativamente na relação e a via úmida sempre apresentou valores superiores. Finalmente, concluiu-se que não há re1ação significativa entre o grau de maturação e os seguintes parâmetros: % ácido clorogênico total, % monoisômero total, % diisômero total, a soma de % monoisômero + % diisômero, a atividade da polifenoloxidase (PPO) e a atividade específica da PPO. Foi demonstrado que a PPO extraí da do café atuou tanto nos monoisômeros extraídos do mesmo café como nos diisômeros, embora a velocidade da reação seja um pouco maior com os monoisômeros como substratoAbstract: The main objective of this research was to ascertain whether or not a variation in the ratio % monoisomer: % diisomer of coffee caffeoi1quinic acid occurred during maturation, since such a variation could directly affect cup quality. The analyses were carried out in samples of Coffea arabica cv Catuai vermelho, prepared both by the dry and wet processing methods. A high level of significance was found between the ratio % monoisomer: % diisomer and maturity. From the partial1y green to the overripe stages. The results indicated that the inclusion of partially green berries could negatively affect beverage flavour, since the beans from these berries showed lower ratios than the remainder. The high ratios found in the beans from totally green berries, a stage known to produce a low quality beverage, indicated that in this stage other factors were more relevant. It was al so shown that the processing methods significantly affected the ratio, the wet method always presenting higher values than the dry method. Finally it was concluded that there was no significant relation between the maturity level and the following parameters: % total chlorogenic acid, % total monoisomer, % total diisomer, the sum of % monoisomer + % diisomer, and the activity and specific activity of the coffee polyphenoloxidase (PPO). It was shown that, the PPO extracted from the coffee attacked both the monoisomer s and the diisomers extracted from the same coffee, although the reaction velocity was slightly higher with the monoisomers as substrateMestradoMestre em Tecnologia de Alimento