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Literacy tearchers and their social representations of science teaching : (re)constructions by collaborative formative practices
No full textOrientadores: Mauricio Compiani, Carlos Alberto de Oliveira Magalhães JúniorTese (doutorado) - Universidade Estadual de Campinas, Instituto de Física Gleb WataghinResumo: Pelas peculiaridades do processo de alfabetização e do perfil polivalente que possuem as professoras alfabetizadoras, pedagogas dos anos iniciais, buscamos identificar as potencialidades de uma proposta de educação continuada sobre as suas representações sociais (RS) de ensino de Ciências. Realizamos uma formação a partir de práticas de caráter colaborativo, com participação de 25 professoras, na tentativa de intervenções sobre como elas relacionavam a Alfabetização Científica (AC) com a sua prática pedagógica, enquanto mediadoras do conhecimento científico para crianças em processo de apropriação da leitura e da escrita. A investigação foi direcionada por princípios da pesquisa-ação colaborativo-crítica e desenvolvida em três etapas: a priori, durante e a posteriori ao desenvolvimento da proposta formativa - um curso de extensão universitária da Faculdade de Educação (FE) da Universidade Estadual de Campinas (Unicamp), no município de São Mateus, Espírito Santo ¿ ES, perfazendo o total de 92 horas. Valorizando os saberes docentes instituídos, buscamos construir um espaço formativo dialético, reflexivo e crítico, na dialogicidade sobre AC no Ciclo de Alfabetização, pautado no ensino de Ciências sob a perspectiva da educação Ciência, Tecnologia, Sociedade e Ambiente (CTSA). Realizamos os registros por questionários de evocação livre de palavras, produção das atividades escritas e de sequências didáticas (SD) elaboradas e desenvolvidas pelas professoras, registros fotográficos, gravação em vídeo e áudio, bem como as anotações pelo pesquisador, em diário de bordo, dos diálogos realizados nos encontros formativos. A priori e a posteriori à formação, por técnica de evocação livre de palavras e análise prototípica, identificamos o possível núcleo central das RS sobre ensino de Ciências das professoras, com seus respectivos elementos constituintes. Verificamos que inicialmente a prática docente era fortemente marcada pelas diretrizes traçadas pelo currículo prescrito, apontando tendências limitadoras da atuação docente, polarizadoras dos processos de AC e da apropriação da escrita. Porém, constatamos que após a realização do processo formativo houve alteração do núcleo central das RS das professoras, bem como vestígios de mudanças na sua prática pedagógica, possibilitando-lhes encontrar outros elementos para o ensino da escrita a partir da prática para o ensino de Ciências. Pela análise do conteúdo dos discursos das professoras, sobre o processo formativo, identificamos indícios da relevância da prática colaborativa para a construção dialógica do conhecimento, possíveis influenciadores das suas RS e, consequentemente, da sua prática pedagógica: a troca de experiências dos saberes docentes historicamente instituídos; e a reflexão e crítica sobre a realidade local, dinamizada pela educação CTSA. Os resultados alcançados apontaram ser importante a elaboração e a oferta de propostas de educação continuada às (aos) alfabetizadoras (es), com ênfase no ensino de Ciências na perspectiva CTSA, desenvolvidas por práticas colaborativas. Elas favorecem o protagonismo da sua prática e a (re)construção das RS que possuem de ensino de Ciências, auxiliando-as no ensino da leitura e da escrita a partir das práticas de AC, principalmente pela triangulação possível entre formação continuada, práticas colaborativas e Educação CTSAAbstract: Due to the peculiarities of the literacy process and the polyvalent profile of literacy teachers, pedagogues of the early years, we seek to identify the potential of a proposal for continuing education on their Social Representations (SR) of Science teaching. We carry out training based on collaborative practices, with the participation of 25 teachers, in an attempt to intervene on how they related Scientific Literacy (SL) to their pedagogical practice, as mediators of scientific knowledge for children in the process of reading appropriation and writing. The investigation was guided by principles of collaborative-critical action research and developed in three stages: a priori, during and a posteriori to the development of the training proposal - a university extension course at the College of Education (FE) of the State University of Campinas (Unicamp) , in the city of São Mateus, Espírito Santo - ES, totaling 92 hours. Valuing the established teaching knowledge, we seek to build a dialectical, reflective and critical formative space, in the dialogicity about SL in the Literacy Cycle, based on Science teaching from the perspective of Science, Technology, Society and Environment (STSE) education. We carry out the records by questionnaires of free evocation of words, production of written activities and didactic sequences (DS) elaborated and developed by the teachers, photographic records, video and audio recording, as well as the notes by the researcher, in the logbook, of the dialogues. held in formative meetings. A priori and a posteriori to the training, using the technique of free evocation of words and prototypical analysis, we identified the possible central nucleus of the SR on the teaching of Science by the teachers, with their respective constituent elements. We found that initially the teaching practice was strongly marked by the guidelines outlined by the prescribed curriculum, pointing out trends that limit the teaching performance, polarizing the SL processes and the appropriation of writing. However, we found that after the completion of the training process, there was a change in the central core of the teachers' SR, as well as traces of changes in their pedagogical practice, allowing them to find other elements for teaching writing from the practice for teaching Science. By analyzing the content of the teachers' speeches about the formative process, we identified evidence of the relevance of collaborative practice for the dialogical construction of knowledge, possible influencers of their SR and, consequently, of their pedagogical practice: the exchange of experiences of historically established teaching knowledge; and reflection and criticism about the local reality, driven by STSE education. The results achieved indicated that it is important to elaborate and offer continuing education proposals to literacy teachers, capable of making them protagonists of their practice and that this formative model is important for the (re) construction of RS that they have from Science teaching, assisting them in the teaching of reading and writing from the practices of SL, mainly by the possible triangulation between continuing education, collaborative practices and STSE EducationDoutoradoEnsino de Ciências e MatemáticaDoutor em Ensino de Ciências e Matemática88882.435455/2019CAPE
Incineration and recycling for MSW treatment: case study of Campinas, Brazil
No full textOne of the biggest challenges for developing countries such as Brazil is the adequate management of urban solid waste. In Campinas, the third-largest city in the state of São Paulo with population over one million inhabitants, the treatment of solid waste turned to be a serious problem since 2014. The daily collection of municipal solid waste (MSW) is 1304 t of which only 2.5% is selectively collected, the rest of MSW is landfilled in a neighboring city 40 km distant from Campinas. This paper presents a scenario for the treatment of MSW based on recycling and incineration and evaluates the energy, economic and environmental potentials. In this scenario, a selective collection index of 20% is adopted and the rest of MSW is incinerated with energy recovery. Results show that incineration can generate electrical energy sufficient for 135,680 homes and can render about US 302,412 per month equivalent to 1120 national minimum salary, energy savings equivalent to 69.4 MW and avoided emissions of about 145.77 ktCO2/year equivalent to 6.2% of the total emissions of Campinas35752757CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQSem informaçã
Association of VEGFA-2578 C4A polymorphism with clinicopathological aspects and outcome in follicular lymphoma patients
No full textsem informação6sem informaçã
Crystal structure of the human Tip41 orthologue, TIPRL, reveals a novel fold and a binding site for the PP2Ac C-terminus
No full textTOR signaling pathway regulator-like (TIPRL) is a regulatory protein which inhibits the catalytic subunits of Type 2A phosphatases. Several cellular contexts have been proposed for TIPRL, such as regulation of mTOR signaling, inhibition of apoptosis and biogenesis and recycling of PP2A, however, the underlying molecular mechanism is still poorly understood. We have solved the crystal structure of human TIPRL at 2.15 angstrom resolution. The structure is a novel fold organized around a central core of antiparallel beta-sheet, showing an N-terminal alpha/beta region at one of its surfaces and a conserved cleft at the opposite surface. Inside this cleft, we found a peptide derived from TEV-mediated cleavage of the affinity tag. We show by mutagenesis, pulldown and hydrogen/deuterium exchange mass spectrometry that this peptide is a mimic for the conserved C-terminal tail of PP2A, an important region of the phosphatase which regulates holoenzyme assembly, and TIPRL preferentially binds the unmodified version of the PP2A-tail mimetic peptide DYFL compared to its tyrosine-phosphorylated version. A docking model of the TIPRL-PP2Ac complex suggests that TIPRL blocks the phosphatase's active site, providing a structural framework for the function of TIPRL in PP2A inhibition6CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPsem informaçãosem informação2011/03054-
Bone metabolic metrics in PET/CT images for multiple myeloma patients
No full textOrientador: Celso Dario RamosTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: Lesões no tecido ósseo atingem cerca de 80% dos pacientes portadores de mieloma múltiplo (MM). O diagnóstico precoce ajuda a prevenir a evolução das lesões e possibilita o manejo clínico correto do paciente. Imagens anatômicas de ressonância nuclear magnética (MRI) e imagens hibridas de tomografia por emissão de pósitron com flúor-18 e tomografia computadorizada (PET/CT com FDG-18F) são as mais indicadas para a avaliação dos pacientes de MM. As imagens PET/CT com FDG-18F permitem, além da avaliação visual qualitativa, a extração de indicadores metabólicos quantitativos, sendo o standardized uptake value (SUV), o mais conhecido deles. Atualmente, outros parâmetros têm sido descritos entre eles metabolic tumor volume (MTV) e total lesion glycolysis (TLG), mas ainda não foram completamente estabelecidos. Neste contexto, este estudo propôs um método computacional semiautomático para obter indicadores metabólicos em imagens PET/CT com FDG-18F para avaliação do tecido ósseo em pacientes com MM, através da segmentação do esqueleto utilizando imagens CT. Foram avaliados, retrospectivamente, imagens de corpo inteiro de PET/CT com FDG-18F de 59 pacientes, de ambos os sexos, com idade superior a 18 anos, diagnosticados com MM submetidos a exames no Serviço de Medicina Nuclear do Hospital de Clínicas da Unicamp entre 2013 e 2018, no início de seu tratamento para a doença. Para estes pacientes foram calculados do SUV máximo, o SUV médio e o desvio padrão do SUV exclusivamente para o tecido ósseo. Também, foram propostos dois novos parâmetros metabólicos definidos como porcentagem de envolvimento ósseo (percentage of bone involvement - PBI) e Intensidade do envolvimento ósseo (intensity of bone involvement - IBI). As variáveis SUV médio (odds ratio [OR]: 10,52; 95%CI: 5,68-19,48; p?Abstract: Bone lesions are reported in approximately 80% of Multiple Myeloma (MM) patients. Early and precise evaluation of bone involvement is crucial for staging and correct disease management. Anatomical images of nuclear magnetic resonance (MRI) and hybrid image of positron emission tomography with 18F fluorodeoxyglucose and computed tomography (18F-FDG PET/CT) are the main methods for the evaluation of MM patients. 18F-FDG PET/CT allows for a qualitative visual evaluation and also the calculation of quantitative metabolic indicators such as the standardized uptake value (SUV). Currently, other parameters are being studied like the metabolic tumor volume (MTV) and total lesion glycolysis (TLG), but these are not yet fully established. In this context, this study proposes a semi-automatic method using CT-based skeleton segmentation to obtain quantitative metabolic parameters from 18F-FDG PET/CT for bone and bone marrow evaluation of MM patients. We retrospectively evaluated whole-body 18F-FDG PET/CT images of 59 MM patients, male and female older than 18. These patients underwent to PET/CT scans between 2013 and 2018, at the Division of Nuclear Medicine of the Clinical Hospital of the University of Campinas, at the beginning of their treatment. For each patient, the maximum SUV, mean SUV and standard deviation of SUV of all bone tissue were calculated. Also, two new metabolic parameters defined as percentage of bone involvement (PBI) and intensity of bone involvement (IBI) were proposed. For the SUV, the mean (odds ratio [OR]: 10.52; 95%CI: 5.68-19.48; p?DoutoradoClínica MédicaDoutora em Ciências001CAPE
Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks
No full textIn the past decade, significant progress has been made in understanding the role of protein tyrosine phosphatase as a positive regulator of tumor progression. In this scenario, our group was one of the first to report the involvement of the low molecular weight protein tyrosine phosphatase (LMWPTP or ACP1) in the process of resistance and migration of tumor cells. Later, we and others demonstrated a positive correlation between the amount of this enzyme in human tumors and the poor prognosis. With this information in mind, we asked if LMWPTP contribution to metastasis, would it have an action beyond the primary tumor site. We know that the amount of this enzyme in the tumor cell correlates positively with the ability of cancer cells to interact with platelets, an indication that this enzyme is also important for the survival of these cells in the bloodstream. Here, we discuss several molecular aspects that support the idea of LMWPTP as a signaling hub of cancer hallmarks. Chemical and genetic modulation of LMWPTP proved to shut down signaling pathways associated with cancer aggressiveness. Therefore, advances in the development of LMWPTP inhibitors have great applicability in human diseases such as cancer78412631273CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP141723/2019-0; 303900/2017-2sem informação2018/03593-6; 2017/08119-8; 2015/11433-0; 2015/20412
The elderly and the electronic government in Brazil
No full textThe use of information technology can increase the quality of life of senior citizens. The elderly tend to be more cautious and seek greater certitude before they act when compared to younger individuals. In Brazil, the elderly are already 13% of the population. The objective of this research was to study what factors influence the elderly in the use of e-government in Brazil. The focus of this study was to investigate an initiative of the Brazilian government to computerize fiscal control mechanisms. We interviewed 137 elderly individuals who have used the program. We used a quantitative methodology for the development of this research, through the multivariate analysis technique of structural equation modeling. The study presented a robust model with a high explanatory power, in which the influencing factors are: Performance Expectancy, Facilitating Conditions and Habit. The research assists in the participation and involvement of the elderly in the current e-government development phase in Brazil, exposing their perceptions2329530215th IFIP Electronic Government (EGOV) / 8th IFIP WG 8.5 International Conference on Electronic Participation (ePart
Cumulative mutation and new selection strategies for trichoderma harzianum 3PCE6 hypercelulolytic mutants
No full textsem informação33SP8-223S102S10217th European Congress on Biotechnolog
Strength training prevents hyperinsulinemia, insulin resistance, and inflammation independent of weight loss in fructose-fed animals
No full textThe aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8-14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P < 0.05). All three exercise protocols induced a remarkable reduction in inflammation, tissue triglyceride content, and inflammatory pathways, which was achieved through c-Jun NH2-terminal kinase (JNK) phosphorylation and factor nuclear kappa B (NFkB) activation in both the liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases6FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP2013/20293-2; 2013/21491-2; 2016/14380-
