Qazvin University of Medical Sciences

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    10283 research outputs found

    Occurrence of Dioctophyme renale (Goeze, 1782) in road-killed canids of Iran and its public health implication

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    Dioctophyme renale, is the largest of parasitic nematodes, which infects different species of fish-eating carnivores worldwide. The northern provinces of Iran (Guilan and Mazandaran) located in south of the Caspian Sea are suitable for parasitic infections due to the mild and humid climatic conditions. From separate surveys of road-killed canids in various parts of the Caspian Sea littoral area in Iran, 70 carcasses were collected along the roads of Guilan and Mazandaran from 2015 to 2017. Dioctophyme renale detected by direct observation and molecular methods based on Cytochrome c oxidase subunit 1 (COX1 gene) sequencing analysis. Molecular investigation was also performed to validate prevalence and reduce false negative concerns. Dioctophyme renale was found in eight of 70 carnivores, mostly in the right kidneys, as well as two cases in the abdominal cavity of a dog and a golden jackal. More carcasses on the roads were seen with lacerated internal organs. Given the frequent number of giant kidney worms in canids in the region, the transmission of this zoonotic helminth to humans seems possible, since the area is a tourism hub in the country. The infection burden of this helminth should be investigated using DNA analysis of kidney tissue of road-killed carnivores in Iran. Keywords: Giant kidney worm, COX1, gene Carnivores, Conventional PCR, One healt

    Parasites in surgically removed appendices as a neglected public health concern: a systematic review and meta-analysis

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    The role of various parasitic infections in the occurrence of appendicitis is illustrated through cases recorded all over the world. The purpose of the current study was to estimate the global prevalence of parasite infestation (other than E. vermicularis) in appendectomy specimens. In the setting of the PRISMA guidelines, multiple databases (Science Direct, Scopus, Web of Science, PubMed, and Google Scholar) were explored in articles published until 28 September 2020. Totally, 62 studies (106 datasets) with 77, 619 participants were included in the analysis. The pooled prevalence of parasites in appendectomy samples was as follows; 0.012% (95% CI; 0.004–0.025) for Ascaris lumbricoides, 0.004% (95% CI; 0.001–0.009) for Trichuris trichiura, 0.025% (95% CI; 0.007–0.052) for Schistosoma mansoni, 0.002% (95% CI; 0.001–0.005) for Taenia spp., 0.061% (95% CI; 0.020–0.122) for Entamoeba histolytica and 0.034% (95% CI; 0.018–0.056) for Giardia lamblia. Our results demonstrated that the risk of appendicitis may increase in the presence of helminth and protozoan infections. As such, the most cases of parasites in appendectomy specimens were reported in developing countries. Regular screening plans for diagnosis, treatment and prevention are needed for prevention of parasitic infection as well as parasitic associated appendicitis, especially in endemic regions of the world. KEYWORDS ,Prevalence; worldwide; appendicitis; parasitic infestation; histopathological method

    Comparing respiratory symptoms and spirometry disorders among healthy people and workers of indoor swimming pools: A case–control study

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    BACKGROUND: The water disinfection of swimming pools through chlorination method causes unwanted changes such as chlorine‑containing byproducts within the air, which might affect the swimming pool workers’ respiratory health. The present study is aimed to determine the frequency of respiratory symptoms and spirometry abnormalities among the workers of indoor swimming pools (instructors and lifeguards). MATERIALS AND METHODS: The present case–control study was conducted on forty individuals working in indoor swimming pools and forty others working at chlorine‑exposure‑free jobs as the control group. A questionnaire, including demographic information, smoking information, respiratory symptoms, and years of employment in the swimming pool, was completed for every participant. All the personnel, as well as the participants in the control group, underwent pulmonary examinations and spirometry tests. Then, the obtained data were analyzed using the SPSS 16 software as well as the statistical tests, including t‑test, Chi‑square test, correlation coeffcient, and regression analysis. RESULTS: The mean age of the participants in the case and control groups was 32.3 and 32.5 years, respectively. Both the case and control groups consisted of 18 males (45%) and 22 females (55%). Among the respiratory symptoms, lacrimation, rhinorrhea, sneeze, throat irritation, and chest tightness were signifcantly higher in the case group than that of the control group (15%, 80%, 35%, 57.5% and 72.5% vs. 0%, 40%, 12.5%, 2.5% and 27.5%, respectively). The pulmonary examinations indicated a statistically signifcant difference between the two groups in terms of the prevalence of wheeze and rhonchi (P = 0.014 and 0.006, respectively). Moreover, showing a statistically signifcant difference, the forced vital capacity (FVC) and forced expiratory volume in 1 s/FVC indicators were lower in the case group than the control group (P = 0.04 and 0.016). CONCLUSION: Regarding the fndings, there was a direct relationship between working in indoor swimming pools and the prevalence of respiratory symptoms and pulmonary dysfunction. Keywords: Chlorine compounds, respiratory symptoms, spirometry, swimming pool

    The Effect of Peers Support on Fear of Hypoglycemia in Iranian Patients with Type 1 Diabetes: A Clinical Trial Study

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    Background: Fear of hypoglycemia is a medical emergency which leads to disrupt individuals’ normal lives. Peers support is a hopeful approach to improve diabetes self‑care behaviors. This study was conducted to assess the effect of peers support on the fear of hypoglycemia in patients with type 1 diabetes. Materials and Methods: This randomized clinical trial study was performed among 60 patients with type 1 diabetes in Qazvin city from September 2019 to October 2020. Patients were assigned to control and intervention groups using a random method. The data collection tools included demographic characteristics and a standard questionnaire for Hypoglycemia Fear Survey (HFS). Patients in the intervention group were trained by skilled peers for 2 months, but those of the control group only received routine hospital training. The data were analyzed by SPSS version 16 and paired and independent t‑test. Results: The scores of the fear of hypoglycemia in diabetic patients in the two groups had no significant statistical difference before intervention (t53 = 0.93, p = 0.94). But after the intervention, the independent t‑test showed that there was a significant difference between the scores of the fear of hypoglycemia in both groups (t53 = ‑2.13, p = 0.03). Conclusions: Considering the results of the current study, peer support for diabetic patients is an effective way to reduce the fear of hypoglycemia. Therefore, it is recommended using this training method to train diabetic patients. Keywords: Diabetes mellitus, fear, hypoglycemia, Iran, peer group, type

    A theory-based intervention to promote medication adherence in patients with rheumatoid arthritis: A randomized controlled trial

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    Introduction/objectives Adherence to prescribed medication regimens is fundamental to the improvement and maintenance of the health of patients with rheumatoid arthritis. It is therefore important that interventions are developed to address this important health behavior issue. The aim of the present study was to design and evaluate a theory-based intervention to improve the medication adherence (primary outcome) among rheumatoid arthritis patients. Methods The study adopted a pre-registered randomized controlled trial design. Rheumatoid arthritis patients were recruited from two University teaching hospitals in Qazvin, Iran from June 2018 to May 2019 and randomly assigned to either an intervention group (n = 100) or a treatment-as-usual group (n = 100). The intervention group received a theory-based intervention designed based on the theoretical underpinnings of the health action process approach (HAPA). More specifically, action planning (making detailed plans to follow medication regimen), coping planning (constructing plans to overcome potential obstacles that may arise in medication adherence), and self-monitoring (using a calendar to record medication adherence) of the HAPA has been used for the treatment. The treatment-as-usual group received standard care. Results Data analysis was conducted based on the principle of intention to treat. Using a linear mixed-effects model (adjusted for age, sex, medication prescribed, and body mass index), the results showed improved medication adherence scores in the intervention group (loss to follow-up = 16) compared to the treatment-as-usual group (loss to follow-up = 12) at the 3-month (coefficient = 3.9; SE = 0.8) and 6-month (coefficient = 4.5; SE = 0.8) follow-up. Intervention effects on medication adherenc

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