Qazvin University of Medical Sciences
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Co-delivery of doxorubicin and epacadostat via heparin coated pH-sensitive liposomes to suppress the lung metastasis of melanoma
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Polysomnography findings of patients with overlap syndrome according to severity of lower airway obstruction
Get PDFBackground: The concurrence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is known as
overlap syndrome (OS). The obstruction of the upper airway leads to OSA and the obstruction of the lower airway leads to COPD. The
aim of this study was to compare polysomnographic findings of patients with OS according to severity of lower airway obstruction.
Materials and Methods: Seventy‑two patients were included in this cross‑sectional study. Patients with COPD referred to a sleep
clinic with suspicion of OSA were evaluated by polysomnography (PSG). PSG findings were interpreted based on the American
Academy of Sleep Association criteria (2012). COPD severity was categorized into four groups based on GOLD criteria using forced
expiratory volume in the first second (FEV1). PSG findings also were compared between patients regarding severity of lower airway
obstruction (FEV1 ≥50% and FEV1 <50%). Results: Sixty‑eight of the patients had OS. Twenty‑nine (42.6%) were male. The mean
age was 62.3 پ} 6.88 years. Thirty‑two (54.4%) of the patients were in GOLD 2. The mean apnea/hypopnea index was 57.41 پ} 36.16.
Seventy‑two percent of patients had severe OSA. Severe OSA was more prevalent in patients of GOLD 2 and 3 groups compared
to the other groups. Among PSG findings, only N2 sleep stage was significantly longer in patients with FEV1 < 50% than in patients
with FEV1 ≥50% (61.5 پ} 11.2, 55.3 13.4, P = 0.039). Conclusion: Polysomnographic findings (except N2 stage) are not different in
patients with OS with respect to severity of lower airway obstruction.
Key words: Chronic obstructive pulmonary disease, overlap syndrome, polysomnography, sleep apne
Evaluation of Tetracycline Antibiotic Residue in Honey Samples Using ELISA and HPLC
Get PDFABSTRACT: Honey is used worldwide due to its medicinal and nutritional properties. Antibiotics are used to treat
diseases such as American foulbrood and European foulbrood or as a drug for preventing disease in the beehives.
Antibiotic residues should be carefully monitored because they can have adverse effects on the general health of
human. In this study, the amount of tetracycline residue was measured in honey samples. A total of 80 honey samples
were collected from different regions of Qazvin province, Iran. The methods used included enzyme-linked
immunosorbent (ELISA) assay and high-performance liquid chromatography (HPLC). ELISA method showed that the
maximum and minimum levels of tetracycline residue were 40 ppb and 1.26 ppb, respectively. The areas with values
above the kit’s LOD include Takestan (14.28%), Abeyek (4.76%), and Alamot-e-gharbi (4.54%), respectively. In the
Alamot-e-sharghi samples, the antibiotic values above the kit’s LOD were not found. Samples with values above the
kit’s LOD in ELISA method were measured using HPLC method. According to ELISA results, of the 80 honey
samples, 4 samples (5%) had antibiotic more than the highest LOD of the kit. These 4 samples were tested using
HPLC method. The results of HPLC showed that out of 4 honey samples, one sample was more than 40 ppb, but 3
samples were less than 40 ppb. There is a significant difference between ELISA and HPLC (p < 0.05). If the antibiotic
residue levels of tetracycline are too high in food, it can cause serious harm to the health of consumers, therefore,
monitoring of antibiotics residue in food is very necessary
Sleep problems during COVID-19 pandemic and its’ association to psychological distress: A systematic review and meta-analysis
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ارزیابی تاثیر تمرینات اصلاحی بر انحرافات توراسیک و لومبار در بین دانشجویان دختر ساکن در خوابگاه¬های دانشگاه علوم پزشکی قزوین (چکیده طرح تحقیقاتی)
Get PDFمقایسه عملکرد تکنیک FRAME و شاخص ایمنی بیمارستان ( HSI) در ارزیابی و تحلیل سطح ریسک حریق بخش های پر خطر بیمارستان ولایت شهر قزوین در سال 1398 (چکیده طرح تحقیقاتی)
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