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First detection of mobilized colistin resistance mcr-1 gene in Escherichia coli isolated from livestock and sewage in Iran
Get PDFCurrently, few studies have investigated the mechanisms of resistance to colistin in Iran. The aim of this study was to investigate mcrharbouring Escherichia coli dissemination in livestock and sewage in Iran. A total of 115 samples from cows (n = 38), chickens (n = 47)
and urban sewage samples (n = 30) were collected. The presence of genes including mcr1–6 and ampC β-lactamase (blaMOX, blaCIT,
blaDHA, blaACC, blaEBC, blaFOX) for colistin-resistant isolates was investigated by multiplex PCR method. Genetic association of colistinresistant strains was also evaluated by ERIC PCR. Sixty-five isolates were identified as E. coli. Meaningless were resistant to colistin. The
highest (26.1%) and lowest (3.07%) resistance were shown to ampicillin and meropenem respectively. Among the three colistin-resistant
isolates, 2 (66%) were multidrug resistant, with one of them being mcr-1 positive and the other one positive for DHA ampC β-lactamase
gene. No mcr2–6 genes were found. Minimum inhibitory concentration of mcr-producing isolate was 4 mg/L by microbroth dilution. This
study reports, first the detection of mcr-1 in E. coli from farm animals in Iran, a finding that is indicative of a global distribution of this
plasmidic element and threatning the use of colistin as a last resort antibiotic. No clonal relationship was observed between the colistinresistant E. coli isolates by ERIC-PCR. Monitoring the presence of these strains in animal sources help as to controlling the spread of
resistance genes from animal to human is vita
بررسی مقايسه ای مقاومت به شکست ريشه دندانهای درمان ريشه شده با استفاده از دو نوع سیلر مختلف در محیط آزمايشگاهی
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بررسی ارتباط بین سطح سواد سلامت با کیفیت زندگی در بیماران مولتیپل اسکلروزیس مراجعه کننده به بیمارستان بوعلی قزوین در سال۹۸
No full textPrevalence of Strongyloides stercoralis in the immunocompetent and immunocompromised individuals in Iran: a systematic review and meta-analysis
Get PDFStrongyloidiasis is a neglected tropical disease mostly distributed in tropical and subtropical regions. The current study evaluated the prevalence of Strongyloides stercoralis in immunocompetent and immunodeficient patients in Iran. The available online literature published from June 1994 to October 2020 was obtained from multiple English databases (PubMed, Science Direct, Scopus, Web of Science and Google Scholar) and four Persian databases (Magiran, Iran Medex, Iran Doc and SID). All statistical analyses were performed using R software (version 3.6) meta-package and p-values <0.05 were considered significant. From 1051 articles, 74 studies (248 656 individuals) met the inclusion criteria. The pooled prevalence of S. stercoralis was 2% (95% confidence interval [CI] 1 to 3) and 4% (95% CI 1 to 8) in immunocompetent and immunodeficient patients, respectively. In immunodeficient cases, the pooled prevalence of studies utilizing serology, culture and microscopic methods was 10% (95% CI 2 to 23), 1% (95% CI 0 to 6) and 1% (95% CI 0 to 1), respectively. In immunocompetent cases, the pooled prevalence of studies utilizing microscopic, culture and molecular methods was 2% (95% CI 1 to 3), 2% (95% CI 1 to 4) and 2% (95% CI 0 to 6), respectively. We propose an appropriate screening and control program along with comprehensive research regarding the frequency of strongyloidiasis in the country
A systematic review of the prevalence of anxiety among the general population during the COVID-19 pandemic
Get PDFBackground: The COVID-19 pandemic has had an adverse effect on the mental health of population worldwide.
This study was conducted to systematically review the existing literature to identify the individuals at higher risk
of anxiety with a view to provide targeted mental health services during this outbreak.
Methods: In this study, the studies focusing on anxiety prevalence among the general population during the
COVID-19 pandemic were searched in the PubMed, EMBASE, Scopus, Web of Science (WoS) and Google Scholar
from the beginning of Covid-19 pandemic to February 2021.
Results: 103 studies constituting 140732 people included in the review. The findings showed that anxiety
prevalence was 27.3% (95% CI, 23.7%; 31.2%) among general population while the prevalence in COVID-19
patients was 39.6% (95% CI, 30.1%; 50.1%). Anxiety was significantly higher among females and older adults
(p≤0.05). In addition Europe revealed the highest prevalence of anxiety 54.6% (95% CI, 42.5%; 66.2%) followed
by America 31.5% (95% CI, 19%; 47.5%) and Asia 28.3% (95% CI, 20.3%; 38%). In the general population the
highest prevalence of anxiety was in Africa 61.8% (95% CI, 57%-66.4%) followed by America 34.9% (95% CI,
27.7%-42.9%), Europe 30.7% (95% CI, 22.8%-40%) and Asia 24.5% (95% CI, 20.7%-28.9%).
Conclusion: During the COVID-19 crisis, through identifying those who are more likely to be suffered from mental
disorders at different layers of populations, it would be possible to apply appropriate supportive interventions
with a view to provide targeted mental health services during the outbreak
Validation of the Persian version of Skindex-16 among older patients with skin diseases
Get PDFBackground: Skin conditions often considerably impact the older patients’ psycho-social health and quality of life
(QoL). The present study was aimed to examine the validity and reliability of the Persian version of Skindex-16 among
older people with skin diseases.
Methods: In this validation study, 260 older patients sufering from a range of skin conditions were recruited from
a dermatology clinic in Rasht, Iran. Data were collected using a checklist for demographic and clinical characteristics
and the Skindex-16 questionnaire. In this study, validity (face, content, and construct) and reliability (Cronbach’s alpha)
of the Skindex-16 were assessed and reported.
Results: The mean age of participants was 64.51±5.04 years. The results of confrmatory factor analysis showed that
the model had acceptable ftness into the expected three-factor structure [χ 2 /df=249.363, P < 0.001; GFI=0.961; TLI
=0.952; RMSEA=0.078 (90% CI=0.06, 0.09) and SRMR=0.06]. The reliability analysis results confrmed that the values
of Cronbach’s alpha coefcient for Skindex-16 were in the acceptable range (0.923).
Conclusions: Our evaluation of the Skindex-16 indicates that it is reliable and a valid instrument that can be used for
measuring QoL for Iranian dermatologic patients.
Keywords: Aging, Health-related quality of life, Skindex-16, Validatio
