Qazvin University of Medical Sciences
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the impact of covid-19 pandemic on hospital key performance indicators )فایل ارائه ژورنال کلاب(
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بررسی شاخص های زمانی اورژانس پیش بیمارستانی در دانشگاه علوم پزشکی قزوین و ارائه راهکارهای بهبود (فایل ارائه تصویب عنوان)
Get PDFاندازه گیری میزان بی فنیل های چند کلره غیرمشابه دیوکسین (NDL-PCBs)در انواع کنسروهای خوراکی پرمصرف (فایل ارائه تصویب عنوان)
Get PDFStudy the Effect of Au-Nanorod Conjugated With P28 Peptide on Breast Cancer Cell Line Model (Mcf-7) Using Hyperthermia
Get PDFAbstract:
Background and Aim: Breast cancer, as the most common cause of women’s death in the world, has different treatment methods that are not specific and targeted. Recently, hyperthermia has received much attention as one of the auxiliary methods of cancer treatment, which locally causes a controlled increase in tumor temperature (in the range of 43-49 ℃). Nowadays, the use of gold nanoparticles with biological biomolecule coating without side effects seems absolutely necessary for the faster transfer and distribution of heat in the cells, which specifically enters the cancer cell. Therefore, in this study, the therapeutic effect of hyperthermia on breast cell lines was evaluated using gold nanorods coated with polyethylene glycol and P28 peptide (derived from the azurin protein of Pseudomonas aeruginosa).
Materials and methods: In this research, gold nanorods with absorption peaks of 810 and 507 nm were synthesized by seedless growth method and coated with polyethylene glycol and p28 peptide, and their characteristics were determined using spectrophotometric spectra (UV-VIS), Fourier transform to infrared ( FTIR), dynamic light scattering (DLS), transmission electron microscopy (TEM) images were confirmed. Their stability and viability were checked by MTT test. Then, using infrared laser radiation (Hyperthermia Laser) with wavelength (808 nm) and continuously for 1 minute, the therapeutic effect of this complex on breast cancer cells (MCF-7) and normal breast cells (MCF-10A) It was evaluated in vitro.
Results: The obtained results indicated the synthesis of gold nanorods with the size of (4.36±25.31)*(0.88±4.52) and its conjugated with polylinker and P28 peptide, respectively. The results of laser hyperthermia on cell lines showed that the complex (GNR-PEG-P28) along with laser light radiation caused the death of 50% of breast cancer cells (MCF-7) compared to the normal line (MCF-10A).
Conclusion: The results of this study showed the targeted treatment of breast cancer using nanorods coated with P28 peptide and hyperthermia method for 1 minute. In this method, due to the targeting of the complex, the amount of damage to healthy cells is greatly reduced.
Key words hyperthermia, P28 peptide, breast cancer, MCF-7, NI
Association of weekly or biweekly use of 50.000 IU vitamin D3 with hypervitaminosis D
Get PDFSince the beginning of COVID-19 pandemic, many Iranian people are taking 50.000 IU of vitamin D3 on the weekly or biweekly bases in order to enhance their immune system function. This cross- sectional study was conducted on the patients of endocrinology clinic to compare 25(OH)D levels of weekly or biweekly consumption with the monthly users of vitamin D3 50,000 IU. The level above 100ng/ml of 25(OH)D was defined as hypervitaminosis D. Totally, 211 patients (108 and 103 patients in monthly and weekly/ biweekly groups, respectively) were studied. In the subgroups of weekly and biweekly users, the rates of hypervitaminosis were 18.9% and 4.5%, respectively. In contrast, only 0.9% of monthly users had hypervitaminosis D. The highest vitamin D value of 185 ng/ml was detected in a patient who consumed 50,000 IU vitamin D3 weekly for 6 years. No hypercalcemia was detected in the patients with hypervitaminosis D
ABO and Rh blood groups in patients with lupus and rheumatoid arthritis
Get PDFBackground: Systemic lupus erythematous (SLE) and rheumatoid arthritis (RA) are
autoimmune diseases in which the antigen-antibody system plays an important role. As
blood group and Rh are determined by the presence or absence of antigens on the surface of
red blood cells (RBCs), we aimed to determine the distribution of ABO and Rh blood groups
in SLE and RA patients and its association with disease manifestations.
Methods: This short communication is based on a study that was conducted on 434 SLE and
828 RA patients. We evaluated the distribution of ABO and Rh blood groups in RA and
SLE patients.
Results: This study projected that in lupus patients, Coombs-positive autoimmune hemolytic
anemia and arthritis were more common among the B blood type and Rh-positive group,
respectively. Furthermore, there was no relation between ABO and Rh blood group and
rheumatoid factor (RF) and anti-Cyclic Citrullinated Peptide (anti-CCP) seropositivity.
Moreover, there was no difference in distribution of blood groups in RA and SLE patients.
Conclusion: The higher frequency of blood group B in hemolytic anemia, and positive Rh
in arthritis in lupus patients, develop the hypothesis of probable role of ABO blood group
antigen in some manifestations of lupus.
Keywords: Rheumatoid arthritis (RA); Systemic lupus erythematosus (SLE); ABO blood
group, Rh blood group
Development and Testing of the Psychometric Properties of the Attitude Towards Medical Device-related Pressure Ulcers/Injuries Questionnaire
Get PDFBACKGROUND: Medical device-related pressure ulcers/injuries (MDRPU/Is) are a serious
concern in health care. PURPOSE: To develop and assess the psychometric testing of a
questionnaire to measure nursing students' attitudes about the care and prevention of MDRPU/Is.
METHODS: Based on a review of the literature, a 26-item questionnaire was developed; face
validity was assessed by ten (10) nursing students. The modified Lawshe's model was used, and
both the content validity index (CVI) and content validity ratio were calculated. Items with a CVI
more than 0.63 were retained. The minimum optimal CVI for the new instrument was 79%.
Qualitative assessments were performed by 10 experienced faculty members. One-hundred-andeighty seven (187) nursing students participated in the construct validity testing of the 11-item
questionnaire. The Kaiser-Meyer-Olkin test of sampling adequacy and Bartlett's test of sphericity
were performed. Following analysis of the main components and the varimax rotation, the factor
analysis was determined. Internal consistency (Cronbach's alpha) and test-retest were determined
using Pearson's correlation and intraclass correlation coefficient to evaluate reliability. RESULTS:
During the face validity phase of the initial 26 items, 7 items had impact scores less than 1.5. After
calculating the CVI and content validity ratio for all items, 8 items did not achieve the desirable
score. After performing exploratory factor analysis on the remaining 11 items, the Kaiser-MeyerOlkin test value was 0.789, and Bartlett's test of sphericity was 0.0001, which was statistically
significant. Internal consistency of items (Cronbach's alpha of 0.77) showed that all items had a
high correlation. The reliability of test-retest was significant using an intraclass correlation
coefficient of 0.75 and Pearson's correlation coefficient of 0.86 at P < .005. CONCLUSION: In
this sample of nursing students, the Attitude Towards Medical-device Related Pressure
Ulcers/Injuries Questionnaire was valid and reliable. Studies including licensed clinicians are
needed to confirm these results
Effect of occupational risk factors in cancer incidence in Iran: a Systematic Review
Get PDFBackground: Cancer is the main cause of death in developed countries and the second main cause of death in
developing countries. The aim of this study was to review the occupational risk factors and cancer incident in
Iran.
Materials and Methods: this present systematic review was done based on Preferred Reporting Items for
Systematic Reviews and Meta-Analyses (PRISMA) guidelines on Persian articles with no time limits in
publication and collected from January 2019 to April 2019 from Sid, Magiran and Google Scholar Databases.
Some search terms including “job” or “occupation” “occupational exposure” or “cancer” or “neoplasm were
used.
Results: A total number of 103 articles were detected. After applying the inclusion and exclusion criteria,
finally 18 studies remained in this systematic review with 13897 sample size and 7187 diagnosed patients. Most
included studies researched on non-melanoma skin as the most studied cancer and sunlight exposure as the most
carcinogenic reported occupational risk factor. Among included researches, only four studies were directly
related to occupational cancer with 1837 sample size and 604 diagnosed various cancers in workers that focused
on kidney, bladder and mesothelioma cancers (Pleural mesothelioma and Perivascular mesothelioma) .The
results showed that, the cancer was reported in some occupations more than others.
Conclusion: Most included researches reported skin cancer and exposure to sunlight as the most studied cancer
and occupational risk factor respectively. As regard to importance of effective risk factors on cancer incidence ,
identification and control of occupational risk factor in the work environment should be a main key element of
national cancer control program in countries specially developing countries. So it is recommended to develop
the researches in field of occupational cancer in Iran
Fire Pathology in a Military Hospital Using the FRAME Technique
Get PDFBackground and Aim: Hospitals are One of the vital and sensitive places as well as practical that maintaining
their function in normal conditions and in times of crisis is one of the biggest concerns of health system managers.
By using the principles of fire safety, hospitals' vulnerability can be reduced. Fire is one of the risks that can lead
to many human and financial losses as well as disruption of hospital performance. Fire risk assessment is a more
effective way to assess the vulnerability, capacity and capability of the hospital. The aim of this study was to
evaluate the risk of fire in one of the hospitals in Tehran to analyze the vulnerability of these uses.
Methods: This cross-sectional study was performed by using the Fire Risk Assessment Method for Engineers
(FRAME) in the hospital building of a military hospital. Fire risk was calculated using the formulas of the
mentioned method in EXCEL software. Factors influencing the level of risk obtained were identified and
evaluated.
Results: The level of fire risk for residents in all units was higher than one. Level factor, fire load factor and
normal protection factor were identified as effective factors that result in the existing fire risk level.
Conclusion: The numerical value of the risk for the residents was at an unfavorable level. The results of this
study showed that the use of FRAME method in assessing the risk of health facilities such as hospitals, by
determining the strengths and weaknesses of the assessed locations, the possibility of identifying effective factors
to predict and prevent accidents and maintain the performance of these centers at times. Be sensitive to such manmade
or natural emergencie