Qazvin University of Medical Sciences
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Study the role of socioeconomic factors on the utilization of inpatient and outpatient services among patients referred to urban and rural health centers in Qazvin in 2019-2020
Get PDFEvaluation of the association between the number and configuration of root canals of mandibular molars in an Iranian subpopulation: A cone‑beam computed tomography study
Get PDFUnderexpression of hsa-mir-449 family and their promoter hypermethylation in infertile men: A case-control study
Get PDFBackground: Post-transcriptional microRNAs (miRNAs) have a impotrant pattern in the
spermatogenesis process.
Objective: Study of the expression and methylation of hsa-miR-449 family in sperm
samples of infertile men.
Materials and Methods: In this case-control study, we recruited 74 infertile
men (with asthenozoospermia, teratozoospermia, asthenoteratozoospermia, and
oligoasthenoteratozoospermia) and 30 control samles. Methylation-specific PCR (MSP)
method was used for methylation evaluation of hsa-miR-449 a, b, c promoter. By Real
time PCR (qRT-PCR) method,we showed downregulation of hsa-miR-449 a, b, c in the
sperm samples of infertile men and compared it to their fertile counterparts.
Results: There was significant underexperssion, in hsa-miR-449-b in
oligoasthenoteratospermic samples (p = 0.0001, F = 2.9). About the methylation
pattern, infertile men showed high frequency of methylation in the promoter of
hsa-miR-449 a, b, c in comparison to controls (60.8% vs 23.3%), the highest amount of
methylation was observed in oligoasthenoteratospermia samples (81.2%).
Conclusion: In this study, low expression and high methylation of hsa-miR-449-b were
observed in infertile men in compared to control samples, which can be one of the
causes of defective spermatogenesis
ارزیابی تاثیر برنامه جلب حمایت همه جانبه به منظور ارتقاء رفتار تفکیک زبالههای پزشکی خانگی (ماسک، دستکش، دستمال کاغذی) توسط شهروندان قزوین، سال 1399: راهبرد کاهش خطر مواجهه با ویروس COVID-19 در کارکنان شهرداری، پرسنل بازیافت زباله و حفاظت از محیط زیست (چکیده طرح تحقیقاتی)
Get PDFبررسی پیش گویی کنندههای روانشناختی تاثیرگذار بر فعالیت جسمانی منظم در بیماران مبتلا به پرفشاری خون با استفاده از چهارچوب مدل رویکرد فرایند اقدام بهداشتی (HAPA) (چکیده طرح تحقیقاتی)
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