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A novel anti-VEGF165 monoclonal antibody-conjugated liposomal nanocarrier system: Physical characterization and cellular uptake evaluation in vitro and in vivo (ارائه ژورنال کلاب)
Get PDFMetabolomic Identification of Anticancer Metabolites of Australian Propolis and Proteomic Elucidation of Its Synergistic mechanisms with Doxorubicin in the MCF7 Cells(ارائه ژورنال کلاب)
Get PDFRelationship between succession and intellectual capital with entrepreneurship in teaching hospitals of Qazvin University of Medical Sciences
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Validating Insomnia Severity Index (ISI) in a Bangladeshi Population: Using Classical Test Theory and Rasch Analysis
Get PDFبررسی شیوع و مقاومت آنتیبیوتیکی سالمونلا انتریتیدیس در تخممرغهای عرضه شده¬ شهر قزوین، سال1398
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Cytotoxic effects of methanolic extract of ferula assa-foetida on skov-3 and mia paca-2 cells
Get PDFIntroduction: Previous studies have demonstrated cytotoxic effects of Ferula assa-foetida. In the present study, the antiproliferative effect of this plant on two species of cancer cells related to pancreatic cancer (MIA PaCa-2) and ovarian cancer
(SKOV-3) was investigated.
Materials and Methods: 100 grams of powdered herb dissolved in 500 milliliter of methanol was placed in Soxhlet extractor for 72 hours. After adding trypsin to the medium, cells were cultured in serum containing medium. A serial dilution of
extract was created with 25, 50, 100, 200 and 400 microgram per milliliter concentrations. Plates were fed with 200 microliters of new mediums at the end of their growth and 50 microliters of MTT were added to all wells of 1 to 11 columns. After
incubation, mediums and MTT were removed from the wells and remaining crystals were resolved by adding DMSO. After
adding glycine buffer (25 μl per well), we immediately read the results at wavelength of 570 nanometer using an ELISA
reader.
Results: Concentrations of 25, 50, 100, 200 and 400 micrograms per milliliter of methanolic extract of Ferula asa-foetida
had significant cytotoxic effect on SKOV-3 and MIA PaCa-2 cancer cells with a P-Value of <0.05. These changes were timedependent.
Discussion and Conclusion: Besides their several medical uses, medicinal herbs have recently turned out to have antineoplastic effects. One of these herbs is Ferula assa-foetida. In the present study, we evaluated the anti-proliferative effects of
this plant on ovarian and pancreatic cancer cells
The relationship between fear of hypoglycemia and sleep quality among type 2 diabetic patient
Get PDFBackground. Fear of hypoglycemia can result in anxiety, stress, anger, depression and severe avoidance
behaviors that it affects the sleep quality of diabetic
patients. Therefore, the present study was conducted
with the aim of investigating the relationship between
fear of hypoglycemia and sleep quality among type 2
diabetic patients.
Methods. The present cross-sectional study was conducted on 400 type 2 diabetic patients referred to endocrinology clinic of Velayat Hospital and Boali Hospital
in Qazvin, in 2019. Data were collected using a checklist
for demographic variables, the Fear of Hypoglycemia
Survey (FHS-W), and the Pittsburgh sleep quality index
(PSQI). Descriptive statistics and Spearman correlation
test were performed for data analysis using SPSS v24.
Results. In this study, the mean age of diabetic patients
was 55.75 ± 10.31. The majority of the participants
were female (n = 299, 74.8%) and were treated with
oral anti-diabetic drugs (n = 174, 43.5%). The mean
score of sleep quality in patients was 8.98 ± 3.64 and
the fear of hypoglycemia was 21.27 ± 11.92. The results of this study showed that there was a significant
relationship between the fear of hypoglycemia and
the poor sleep quality among patients (P < 0.001,
r = 0.305).
Conclusion. The fear of hypoglycemia has a direct and
significant relationship with poor sleep quality in diabetic patients; so that this fear reduces the quality of
sleep in diabetic patients. Therefore, in order to provide
adequate sleep to prevent inappropriate sleep complications, great attention should be paid to the issue of
fear of hypoglycemia, and consider some actions to
reduce this fear