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Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome
Get PDFBackground: Tumor Necrosis Factor Alpha (TNF-α) gene, as an inflammatory factor, plays an important role in reproductive physiology, especially in women with Polycystic Ovary Syndrome (PCOS).
Objective: This study aims to investigate the relationship between the -1031 T/C polymorphism of TNF-α gene and biochemical factors in women with PCOS.
Methods: In this case-control study, participants were 106 women with PCOS and 114 healthy women referred to Kosar Hospital in Qazvin, Iran. The TNF-α gene’s polymorphism was determined using Polymerase Chain Reaction (PCR) technique and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) method. Biochemical factors of serum levels were also measured in two groups. Logistic regression analysis examined the relationship between the frequency of alleles in different states and the risk of PCOS.
Findings: There were statistically significant difference in the mean levels of total cholesterol, triglycerides, testosterone, two-hour blood glucose and body mass index between the groups, whose values were higher in women with PCOS compared to healthy women (P<0.001). In women with PCOS, the mean serum levels of triglyceride and high-density lipoprotein were significantly different between the three TT, CC, TC genotypes of TNF-α gene polymorphism (P<0.05). The results of regression analysis showed that the TT genotype had significant association with the risk of PCOS (OR=2.43, P=0.006, 95%CI: 1.28-2.62).
Conclusion: It seems that there is a relationship between the -1301 (T/C) polymorphism of TNF-α gene and the risk of PCOS in women
Predictors of Post-traumatic Growth in Patients With Myocardial Infarction
Get PDFBackground: Some people experience positive psychological changes in various aspects after a stressful event. These positive changes, known as Post-Traumatic Growth (PTG), are often due to people’s need to adapt to the challenges ahead.
Objective: This study aims to determine the predictors of PTG in patients with myocardial infarction.
Methods: This is a descriptive-correlational study. Participants were 191 patients with myocardial infarction referred to the cardiac clinic of Bu-Ali Sina Hospital in Qazvin, Iran. They were selected using a convenience sampling method and based on inclusion/exclusion criteria. The research instruments were the Post-Traumatic Growth Inventory (PTGI), Multidimensional Perceived Social Support Scale (MSPSS), and the Meaning in Life Questionnaire (MLQ). Collected data were analyzed in SPSS V. 25 software using Pearson correlation test and linear regression analysis.
Findings: There was a significant positive relationship between PTG with perceived social support (r=0.47 and P<0.001) and meaning in life (r=0.71 and P<0.001). Based on the results of linear regression analysis, an increase in the scores of MSPSS and MLQ can increase the PTGI score by 0.978 and 1.376, respectively.
Conclusion: This study provided important insights into the phenomenon of PTG in patients with myocardial infarction and its predictors, which can help improve PTG in them
Analysis of Biofilm-Related Genes and Antifungal Susceptibility Pattern of Vaginal Candida albicans and Non- Candida albicans Species
Get PDFBackground. Vulvovaginal candidiasis caused by Candida species is a prevalent fungal infection among women. It is believed that
the pathogenesis of Candida species is linked with the production of biofilm which is considered a virulence factor for this
organism. The aim of this study was molecular identification, antifungal susceptibility, biomass quantification of biofilm, and
detection of virulence markers of Candida species. Methods. We investigated the molecular identification of 70 vaginal isolates
of Candida species, antifungal resistance to amphotericin B, fluconazole, itraconazole, and voriconazole according to CLSI M27-
A3 and M27-S4, biofilm formation, and frequency analysis of biofilm-related ALS1, ALS3, and HWP1 genes. Results. Our
findings showed that the most common yeast isolated from vaginal discharge was C. albicans (67%), followed by the nonCandida albicans species (33%). All C. albicans complex isolates were confirmed as C. albicans by HWP-PCR, and all isolates of
the C. glabrata complex were revealed to be C. glabrata sensu stricto using the multiplex PCR method. FLC resistance was
observed in 23.4% of C. albicans and 7.7% of C. glabrata. The resistance rate to ITC was found in 10.6% of C. albicans. The
frequency of ALS1, ALS3, and HWP1 genes among Candida species was 67.1%, 80%, and 81.4%, respectively. Biofilm formation
was observed in 54.3% of Candida species, and the highest frequency detected as a virulence factor was for the ALS3 gene
(97.3%) in biofilm-forming species. Discussion. Our results showed the importance of molecular epidemiology studies,
investigating antifungal susceptibility profiles, and understanding the role of biofilm-related virulence markers in the
pathogenesis of Candida strains
Sleep duration and its relationship with school performance in Iranian adolescents
Get PDFBackground. Inadequate or poor sleep quality is common problems in adolescent that affect on their learning, memory and school performance. The present study aimed to determine the association between sleep hours and academic performance in young adults. Methods. This cross-sectional study was designed as a descriptive- analytic study. Samples of adolescents of 14-18 years old in Qazvin city were enrolled. The Pediatric sleep questionnaire and BEARS questionnaire used for all students to screen comprehensively major sleeps problems in them. Chi-square test, t-test, analysis of variance (ANOVA), and correlation were performed to determine the relationship between the data (P < 0.001). Results. Between 653 adolescents, 40% were male and 60% were female. Sleep duration, sleep onset delay, sleep insufficient, rate of oversleeping and academic performance had a direct relationship with gender (P < 0.001). The sleep duration, rate of oversleeping and academic performance were significantly higher in boys, sleep onset delay and sleep insufficient was significantly higher in girls. Time of falling sleep at weekend nights and weekday nights have positively correlation with age (P < 0.001). Also, a significant relationship between students' sleep hours with academic performance was shown (P < 0.001). Conclusions. The overall result was that sleep duration, sleep onset delay, sleep insufficient and rate of oversleeping of students in this study had a significant influence on academic performance. Students without difficulty in falling asleep had good academic performance in compared to students with difficulty in falling asleep. © 2021 Pacini Editore S.p.A.. All rights reserved.
Author keywords
Adolescents; School performance; Sleep duratio
بررسی مقایسه ای تاثیر آموزش به معلمین و مادران بر سبک زندگی ارتقا دهنده سلامت دانش آموزان متوسطه اول
Get PDFPositive Predictive Value of Panoramic Radiography for Assessment of the Relationship of Impacted Mandibular Third Molars with the Mandibular Canal Based on Cone-Beam Computed Tomography: A Cross-Sectional Study
Get PDFتأثیر کشیدن دندانهای پرمولر و انواع متفاوت انکوريج جهت بستن فضا در درمان ارتودنسی، روی ابعاد راه هوايی فوقانی و موقعیت استخوان هايوئید در افراد بزرگسال: يک بررسی سفالومتريک گذشته نگر
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