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Treatment of Hypertension in a Child With 11beta-Hydroxylase Deficiency: A Case Report
Get PDFIntroduction: Deficiency of 11-hydroxylase is clinically presented by external genitalia virilization in girls and precocious puberty in boys. Low renin hypertension occurs in both sexes. Early diagnosis and treatment of hypertension can prevent complications.
Case presentation: We described a 4.5 years old girl of 46.XX, who presented with ambiguous genitalia at birth and hypertension later in follow-up. The patient had received the appropriate dosage of hydrocortisone and the level of 17-hydroxy progesterone was within the acceptable range but the hypokalemia persisted. Both hypertension and hypokalemia were normalized when spironolactone was added.
Conclusion: Intermittent measurement of blood pressure is necessary for patients with 11β hydroxylase deficiency. In these patients, spironolactone is effective in treating mineralocorticoid-mediated hypertension and hypokalemia by blocking mineralocorticoid receptor.
Keywords: Children, Congenital adrenal hyperplasia, 11 beta-Hydroxylase, Hypokalemia, Antihypertensive agent
تاثیر مداخله آموزشی بر مبنای مدل شناخت اجتماعی یکپارچه به منظور بهبود مدیریت مواد زاید شهری و بازیافت در زنان خانه دار شهر لاهیجان(فایل تصویب عنوان)
Get PDFبررسی اثربخشی آموزش آبداران در آگاهی و مهارت های پیشگیری از آلودگی ثانویه آب آشامیدنی شهر قزوین (فایل دفاع نهایی)
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بهینه سازی جذب مالاتیون و دیازینون از محیط آبی با استفاده از نانوکامپوزیت پلی پروپیلن/ دی اکسید تیتانیوم Nano-PP/TiO2) )(فایل دفاع نهایی)
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