Qazvin University of Medical Sciences

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    Ivermectin-Induced Clinical Improvement and Alleviation of Significant Symptoms of COVID-19 Outpatients: A Cross-Sectional Study

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    Although several drugs have been proposed and used to treat the COVID-19 virus, but recent clinical trials have concentrated on ivermectin. It appears that ivermectin can potentially act against COVID-19 and stop the development in its infancy. The purpose of this study was to determine the effect of ivermectin on the recovery of outpatients with COVID-19. In this cross-sectional study, we compared the symptoms reduction in COVID-19 disease in two groups of patients by administering ivermectin. A total of 347 mild outpatients in the Iranian provinces of Qazvin and Khuzestan with a conrmed PCR were enrolled. The symptoms of outpatients with COVID-19 were analyzed using SPSS (V23). In this cross-sectional study, the sex ratio was 0.64 (female/male: 37.9/59.8) and most patients were under 50 years old (72.8%). The results of this study demonstrated a signicant decrease in several COVID-19 disease symptoms, including fever, chills, dyspnea, headache, cough, fatigue, and myalgia in the group administered ivermectin compared to the control group. In addition, the odds ratio of the above symptoms was signicantly lower in patients who received ivermectin than in patients who did not receive the drug (OR = 0.16, 95% CI = 0.09, 0.27). Keywords COVID-19 Ivermectin Cross-sectional study Outpatients Sympto

    COVID‑19 associated rhino‑orbito‑cerebral mucormycosis, risk factors and outcome predictors; a multicentric study

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    Background Since the onset of the Covid-19 pandemic, an increase in mucormycosis cases has been observed in many countries, including Iran. However, the role of covid-19 and associated risk factors have not been thoroughly investigated. Objective This study is designed to identify epidemiologic characteristics, risk factors, and outcome predictors of Covid-19-Associated Rhino-Orbito-Cerebral Mucormycosis (C-ROCM). Methods Data of pathology proven Covid Associated ROCM cases were retrospectively obtained from 7 tertiary care centers throughout Iran from February 20, 2021, to July 22, 2021. Univariate and multivariate analyses were performed using binary logistic regression to assess the effects of various factors on the outcome. Results A total of 132 patients with C-ROCM were included in the study. The mean age of patients was 61.6 ± 13.9 (60.6% male). In 12 patients (9.1%), both eyes were involved. Diabetes was the mostcommon comorbidity (94.7%). The mortality rate was 9.1%, higher in males (12.5%) than females (3.8%). Severe vision impairment was seen in 58 patients (43.9%). Main factors that had a negative impact on the outcome in the univariate analysis include older age (P < 0.001), higher steroid dosage (P < 0.001), higher HbA1c level (P < 0.001), Covid-19 severity (P < 0.001), and brain involvement (P < 0.001). However, in the multivariate analysis, the effects of age (P = 0.062), steroid dosage (P = 0.226), and Covid- 19 intensity (P = 0.084) decreased, and the difference was no longer statistically significant. CRAO was a predictor of mortality in the univariate analysis (P = 0.008, OR = 4.50), but in the multivariate analysis, this effect decreased and was no longer significant (P = 0.125). Conclusion The risk of C-ROCM and its complications may increase in patients with more severe Covid-19, steroid over-prescription, ICU admission due to Covid-19, and poor glycemic control during and after Covid-19 treatment

    Attitude of parents towards oral health and dental treatment of their children during the COVID-19 pandemic

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    Objective: Increased rate of dental caries among children necessitate regular pediatric dental treatments; however, the COVID-19 pandemic has posed significant challenges for dental visits of children, compromising their oral health. To assess the attitude of parents towards oral health and dental treatment of their children during the COVID-19 pandemic. Material and Methods: 232 eligible parents presenting to the Pediatric Dentistry Department of Qazvin Dental School during March and April 2021 seeking dental care for their children were requested to fill out a questionnaire included data regarding demographic information, child’s dental history, attitude about the COVID-19 and risk of dental treatments. Data were analyzed using independent t-test, one-way ANOVA, and Pearson’s correlation coefficient (alpha=0.05). Results: One-third of the parents reported that fear of contraction of COVID-19 was the reason for not seeking dental care during the pandemic. The majority of the parents stated no change in oral hygiene behavior or consumption of sugary foods during the pandemic. Cancellation of previous dental appointments (P=0.038) and unwillingness to seek dental care at present (P=0.015) were significantly correlated with the susceptibility score. The susceptibility score of the parents was also correlated with their psychological status (P=0.016). A significant correlation was noted between the susceptibility score and attitude as well (r=0.287, P<0.001). Conclusion: High level of concern regarding the COVID-19 prevents parents from seeking dental care for their children. It is imperative to take measures to reassure the parents regarding the safety of dental care for their children during the pandemic to ensure continuation of dental care

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