Qazvin University of Medical Sciences
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The effect of educational intervention based on integrated social cognition model to improve urban waste management and recycling in housewives in Lahijan
Get PDFCOMPARATIVE EFFICACY OF 1% CURCUMIN NANOMICELLE GEL AND 2% CURCUMIN GEL FOR TREATMENT OF RECURRENT APHTHOUS STOMATITIS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL
Get PDFThe efficacy of eye movement desensitization and reprocessing in reducing anxiety among female university students with primary dysmenorrhea
Get PDFMolecular dynamics simulations, molecular docking, and kinetics study of kaempferol interaction on Jack bean urease: Comparison of extended solvation model
Get PDFSince the urease enzyme creates gastric cancer, peptic ulcer, hepatic coma, and urinary
stones in millions of people worldwide, it is essential to find strong inhibitors to help
patients. Natural products are well known for their beneficial effects on health and
efforts are being made to isolate the ingredients, the so-called flavonoids. Flavonoids
are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, and cosmetic applications. Kaempferol (KPF) is an antioxidant found in
many fruits and vegetables. Many reports have explained the significant effects of dietary KPF in reducing the risk of chronic diseases such as cancer, ischemia, stroke, and
Parkinson’s. The current study aimed at investigating the inhibitory impact of KPF on
Jack bean urease (JBU) using molecular dynamics (MD) simulations and molecular mechanics Poisson–Boltzmann surface area (MM-PBSA) calculations to confirm the results obtained from isothermal titration calorimetry (ITC), extended solvation model,
and docking software. In addition, UV–VIS spectrophotometry was used to study the
kinetics of urease inhibition. Calorimetric and spectrophotometric determinations of
the kinetic parameters of this inhibition indicate the occurrence of a reversible and
noncompetitive mode. Also, the docking and MD results indicated that the urease had
well adapted to the kaempferol in the binding pocket, thereby forming a stable complex. Kaempferol displayed low binding energy during MMPBSA calculations. The inhibitory potential of kaempferol was confirmed by experimental and simulation data,
but in vivo investigations are also recommended to validate our results
بررسی وضعیت شاخص های دانشگاه کارآفرین در دانشگاه علوم پزشکی قزوین و تاثیر آن بر نگرش کسب و کار دانشجویان تحصیلات تکمیلی (چکیده طرح دانشجویی)
Get PDFSynthesis and characterization of Antibacterial Polyurethane Rigid Foam Nanocomposites by Incorporation of Tea Tree Oil as a Natural Biocide
Get PDFSynthesis and characterization of novel Tea Tree Oil (TTO) loaded antibacterial polyurethane
rigid foam is reported by using two distinct methods. In the first method, the mesoporous silica
used as a carrier for TTO and followed by functionalization with 3-aminopropyltriethoxysilane
(APTS), for preparing of NH2- MCM-41. In the second method, the fabrication of mesoporous
silica nano containers (SiO2NCs) encapsulating TTO was performed by Sol-Gel procedure, which
is known to display antibacterial properties. TTO is loaded in the core of the silica Nano containers
that are stabilized by surfactants as CoreShell nanoparticles (TTO@NH2-SiO2NCs). Field
Emission Scanning Electron Microscopic (FESEM), Transmission Electron Microscopic (TEM),
Fourier transform infrared (FTIR), Brunauer-Emmett-Teller (BET), and Thermogravimetric
Analysis (TGA) analyses were used to characterize morphological, structural, and thermal
properties of the prepared nanoparticles, respectively. The prepared antibacterial polyurethane
rigid foams by having 2.5, 5, 7 percentages of the nanoparticles were studied by FESEM, ATRFTIR, TGA and antibacterial performance assay method, respectively. The obtained results from
Viable cell count (direct contact) method was exhibited that antibacterial polyurethane rigid foam
containing 7% TTO-NH2-MCM-41 has a robust antibacterial activity with >99.9% of the loss of
viability for Staphylococcus aureus bacteria
Activation of apoptosis and G0/G1 cell cycle arrest along with inhibition of melanogenesis by humic acid and fulvic acid: BAX/BCL-2 and Tyr genes expression and evaluation of nanomechanical properties in A375 human melanoma cell line
Get PDFObjective(s): Humic acid (HA) and Fulvic acid (FA) are major members of humic substances, which
are extracted from organic sources including soil and peat. The pro-apoptotic and anti-melanogenic
effects of HA and FA at the cellular and molecular levels in the A375 human melanoma cell line were
examined in this study.
Materials and Methods: The cytotoxicity effect of HA and FA were evaluated by cell viability assay.
Apoptosis and cell cycle were investigated by flow cytometry. Real-time PCR was carried out to
measure the expression of BAX, BCL-2, and Tyr genes. Moreover, the changes in nanomechanical
properties were determined through atomic force microscopy (AFM).
Results: It was found that HA and FA decrease cell viability with an IC50 value of 50 µg/ml (dosedependent) for 14 hr, arrested cells in the G0/G1 phase, and increased the sub-G1 phase (induce
apoptosis). Based on the AFM analysis, Young’s modulus and adhesion force values were increased,
also ultrastructural characteristics of cells were changed. Results of Real-time PCR revealed that HA
and FA lead to a decrease in the expressions of BCL-2 and Tyr genes, and increase the BAX gene
expression.
Conclusion: These results exhibited that HA and FA possess pro-apoptotic effects through increasing
the BAX/ BCL-2 expression in A375 cells. These molecular reports were confirmed by cellular
nanomechanical assessments using AFM and flow cytometry. In addition, HA and FA inhibited
melanogenesis by decreasing the expression of the Tyr gene. It is worthwhile to
The Effect of Topical Lidocaine Gel, Intrauterine Lidocaine Injection and Combination of these Two Methods for Relieving Pain during Curettage: A Double Blind Randomized Clinical Trial
Get PDFIntroduction: Curettage is one of the most common gynecological surgeries in women. Its complication is pain which increases dissatisfaction in patients. Therefore, it is necessary to find a way to treat this complication. This study was performed with aim to compare the effects of three methods of using lidocaine gel in the cervix, intrauterine injection of lidocaine, and a combination of two methods to reduce pain during curettage.
Methods: This clinical trial study was performed in 2017 on 120 patients candidates for curettage in Qazvin Kosar Hospital. Patients were randomly divided into three groups of topical lidocaine gel in the cervix, intrauterine injection of lidocaine and a combination of these two methods, and the drugs were prescribed before curettage. Vital signs and pain were recorded in patients and other information was collected by completing the questionnaire. Data analysis was performed using statistical software (version 22) and chi-square and ANOVA tests. P<0.05 was considered statistically significant.
Results: The intrauterine and intra cervical injection of lidocaine (0.3±0.72) and then injection of intra cervical lidocaine (0.45±0.84) alone significantly reduced pain during curettage in women (P=0.04). On the other hand, no severe hemodynamic changes were observed in these patients. No complications such as nausea and vomiting and no instability of vital signs were observed in any of the groups (P>0.05).
Conclusion: Intrauterine administration along with addition of topical lidocaine gel to the cervix can be used as a simple, low-cost, and safe method as to control pain during and after curettage
PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY OF FOODBORNE BACTERIAL PATHOGENS ISOLATED FROM BAGHLAVA AN IRANIAN EXPORTING PASTRY SWEET
Get PDFBaghlava, a traditional pastry sweet product, are manufactured in Iran and
exported to different countries around the world known as a tasty
confectionery. The aim of this study was to investigate the prevalence and
antibiotic resistance pattern of foodborne pathogens isolated from Baghlava
samples. E. coli, C. sakazakii, Salmonella spp., C. perfringens and S. aureus
were isolated and identified using PCR assay for detection of virulence
factor gene in Baghlava samples. All pathogens except Salmonella spp. were
detected in samples. Total contamination rates of E. coli, C. sakazakii, C.
perfringens and S. aureus were observed 8.92, 7.14, 1.78 and 2.67%,
respectively. Multidrug resistance properties to amoxicillin and ampicillin
have been found in all strains; however, all isolates were susceptible to
ciprofloxacin. Hierarchical clustering and contamination patterns of
pathogens showed that the prevalence of each pathogen is significantly
higher in the southern and northern regions of the city than central areas in
which these products were produce