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Parasites in surgically removed appendices as a neglected public health concern: a systematic review and meta-analysis
Full text linkThe role of various parasitic infections in the occurrence of appendicitis is illustrated through cases recorded all over the world. The purpose of the current study was to estimate the global prevalence of parasite infestation (other than E. vermicularis) in appendectomy specimens.In the setting of the PRISMA guidelines, multiple databases (Science Direct, Scopus, Web of Science, PubMed, and Google Scholar) were explored in articles published until 28 September 2020. Totally, 62 studies (106 datasets) with 77, 619 participants were included in the analysis.The pooled prevalence of parasites in appendectomy samples was as follows; 0.012% (95% CI; 0.004-0.025) for Ascaris lumbricoides, 0.004% (95% CI; 0.001-0.009) for Trichuris trichiura, 0.025% (95% CI; 0.007-0.052) for Schistosoma mansoni, 0.002% (95% CI; 0.001-0.005) for Taenia spp., 0.061% (95% CI; 0.020-0.122) for Entamoeba histolytica and 0.034% (95% CI; 0.018-0.056) for Giardia lamblia.Our results demonstrated that the risk of appendicitis may increase in the presence of helminth and protozoan infections. As such, the most cases of parasites in appendectomy specimens were reported in developing countries. Regular screening plans for diagnosis, treatment and prevention are needed for prevention of parasitic infection as well as parasitic associated appendicitis, especially in endemic regions of the world
Evaluation of effects of P28 Conjugated Superparamagnetic Iron Oxide Nanoparticle as a MRI contrast agent in MCF-7 cells line Model
No full textBackground: Nanoparticles, especially magnetic iron nanoparticles, have received much attention in terms of treatment and diagnosis. Combining this nanoparticle with some compounds can increase its persuasiveness and role more effective. On the other hand, permeable peptides have been able to find a capability in medical science. In the present study, through the binding of peptide to iron nanoparticles, its role in creating the contrast difference of MRI image on MCF7 and MCF10A cell lines has been investigated.
Materials & Methods: At first, the hydrophobic nanoparticle was made as hydrophilic with a silane coating and layered with PEG polymer which can be used as a linker to connect the P28 peptide. After that, the toxicity of this nanoconjugates were investigated by MTT test. The Prussian Blue staining test was used to confirm the entry of these particles into the mentioned cells lines, and finally, nanoconjugate with peptide was used to determine the contrast difference of the MRI image.
Results: Based on the present study, the suitable nanoparticle for the continuation of the research was investigated for further research, which does not have toxic effects on the target cells (up to 250 μg/ml is not toxic). Also, the effect of peptide on the entry of nanoparticles into the mentioned cells was proven. Finally, it was found that this conjugated nanoparticle can cause contrast in MRI images compared to the cases where only uncoated nanoparticle or PEG polymer conjugated are used.
Conclusion: The results of this research show that creating MRI image contrast with the help of magnetic nanoparticles depends on the concentration and the cell-penetrating peptide.
Keywords: magnetic nanoparticle, P28 peptide, MRI image contrast, MCF7 cell
کیفیت زندگی در بیماران مبتلا به پارکینسون : مروری سیستماتیک و متاآنالیز(چکیده طرح هیأت علمی)
Full text linkبررسی عوامل موثر بر نرخ مرگ و میر، طول مدت اقامت و هزینه های کلینیکی بیماران بستری در بخش مراقبت ویژه یکی از بیمارستانهای آموزشی شهر قزوین (چکیده طرح هیأت علمی)
Full text linkبررسی تاثیر مصرف مکمل خوراکی اولئوئیل اتانول آمید بر شاخص های گلیسمی، مقاومت به انسولینی و پروتئین واکنش گرC در بیماران پره دیابت؛ کارآزمایی بالینی دوسوکور کنترل شده با دارونما(چکیده طرح هیأت علمی)
Full text linkInvestigating the role of predictive death anxiety in the job satisfaction of pre‑hospital emergency personnel during the COVID‑19 pandemic
Full text linkBackground: Pre-hospital emergency staffs as the frontline forces fighting against COVID -19 have been affected
by this pandemic. Today, the occupational and mental health of these individuals is particularly important to the
health care system. Death anxiety is one of the inevitable things in this job, and not paying attention to it can cause
unwanted effects such as changing the level of job satisfaction of the personnel. The purpose of this study was to
determine the role of predictive death anxiety in the job satisfaction of pre-hospital emergency personnel during the
COVID-19 pandemic.
Methods: This cross-sectional descriptive study was conducted among pre-hospital emergency staffs in Qazvin
Province, Iran in 2021–2022. Among the bases chosen by the census method, 198 samples were included in the study
by the available method. Data collection tools included the Demographic Checklist, Templer’s Death Anxiety scale,
and the Minnesota Job Satisfaction Questionnaire. The data were analyzed with descriptive and inferential statistics
and SPSS 20 software.
Results: The mean age of the samples was (33.14 ± 6.77). 167 persons were male and the others were female. The
average job satisfaction and death anxiety of the personnel were 55.07 ± 11.50 and 8.18 ± 1.96, respectively. Pearson’s
correlation coefficient between the two variables was r = -0.126 And a null correlation coefficient hypothesis has
been confirmed with p-value = 0.077.
Conclusions: The results showed a high level of death anxiety and average job satisfaction. Although these two variables
do not have a significant relationship with each other, considering that they do not have the appropriate level, it
needs more investigation and consideration
The Relationship Between Fear Caused by Covid-19 with Food Choice Motives and Diet Diversity of People Living in Qazvin City
Full text linkHaplotype Analysis of RAGE Gene Polymorphisms and Association with Increased Risk of Diabetic Nephropathy
Full text linkBackground: The present study aimed at evaluating the association between the -429T/C and -
374T/A polymorphisms of RAGE (Receptor for Advanced Glycation End Products) gene promoter
and diabetic nephropathy as well as examining its possible application as candidate markers of
diabetic nephropathy among the population of Qazvin, Iran.
Methods: In this study, the diabetic patients were divided into the two groups of with or without
nephropathy. The frequency of genotype and allele were determined using TETRA-Primer ARMSPCR. Hardy-Weinberg equilibrium test and correlation of polymorphisms, odds ratio (OR), and
FAMHAP software were used for haplotype analysis.
Results: Based on our data, the CC genotype of -429T/C polymorphism may play a protective
role against the development of nephropathy (OR=0.586, 95%; CI: 0.158-2.167) while, the AA
genotype may be associated with increased risk of the disease (OR=1.889, 95%; CI: 0.454-7.854).
Allele’s analysis revealed that the C allele of -429T/C polymorphism maybe protective against
the appearance of nephropathy (OR=0.794, 95%; CI: 0.48-1.314) whereas, the A allele may be
related to increased risk for nephropathy (OR=1.452, 95%; CI: 0.783-2.695). Haplotype analysis
demonstrated that there was no significant correlation between the two -429T/C and -374T/A
SNPs (χ2=5.125, p value=0.135). However, it was found that the CA haplotype may have a
protective effect against the development of nephropathy (OR=0.48, 95%; CI: 0.14-1.64) while,
the TA haplotype may increase the risk of the disease (OR=2.06, 95%; CI:1.01-4.23).
Conclusion: Overall, no correlation between the -374T/A and -429T/C polymorphisms and the
haplotypes in RAGE gene and the occurrence of diabetic nephropathy, was established.
Keywords: Nephropathy, Type 2 Diabetes, Haplotype, Receptor for Advanced Glycation End
Products, SNP, Iran
Citation: Tavakoli A, Salahshourifar I, Hajialilo