Qazvin University of Medical Sciences
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Evaluation of the primary medical treatments based on the advanced trauma life support principles in trauma patients
Get PDFObjective
In Iran, road traffic accidents were responsible for 14716 deaths in 2015. This study aimed to
compare the initial resuscitation of traumatically injured patients to the internationally recognized
ATLS standards.
Materials and methods
As a cross-sectional study, 506 traumatically injured patients who were referred to the tertiary
referral major trauma center in Poursina Hospital during the study period, were evaluated. All
therapeutic interventions were compared to the ATLS standards. Data on mortality by
demographic was compared to those in whom the ATLS standards were met and in those whom it
was not met
Results
Mean age of the patients was 37.37 ± 19.72 and motorcycle was the most common cause of
accidents (40.9%). ATLS guideline interventions were completely performed in 18.2% of the
patients in their primary hospital, and in rest of 414 cases (81.8%), ATLS algorithms were not
fully carried out. The mortality rate was significantly higher in the second group: 10.86% vs
32.36%, respectively.
Conclusion
Application of ATLS principles in multiple trauma patients can reduce the mortality rate.
Keywords
Trauma, emergency, ATL
Multifunctional betanin nanoliposomes-incorporated gelatin/chitosan nanofiber/ZnO nanoparticles nanocomposite film for fresh beef preservation
Get PDFThe objective of this study was to fabricate betanin nanoliposomes incorporated gelatin/chitosan
nanofiber/ZnO nanoparticles bionanocomposite film (G/CH NF/ZnO NPs/B NLPs) and
investigate its effects on the preservation of fresh beef. The scanning electron microscopy image
of nanocomposite film displayed a good inter-connective porous morphology. Fourier transform
infrared and X-ray diffraction analysis confirmed the formation of new hydrogen bonds and
enhanced crystallinity through the addition of CH NF, ZnO NPs, and B NLPs. The G/CH NF/ZnO
NPs/B NLPs film exhibited satisfactory mechanical properties and high surface hydrophobicity
(water contact angle = 92.49 ± 3.71°). The incorporation of ZnO NPs and B NLPs in the
nanocomposite film provided high antibacterial activity and DPPH inhibition activity (53.02 ±
3.26%). The growth of inoculated bacteria, lipid oxidation, and the changes in the pH and color
quality of the beef samples were controlled by packaging with the fabricated film. In conclusion,
the G/CH NF/ZnO NPs/B NLPs nanocomposite has a high potential for meat preservatio
ارزیابی مقایسه ای سمان گلاس آینومر معمولی و سمان گلاس آینومر تقویت شده با نانو ذرات هیدروکسیآپاتیت بر تجمع استرپتوکوک موتانس و لاکتوباسیل زیر لثه در مجاورت بندهای ارتودنسی
Get PDFبررسی اثر تهیه فضای پست فوری و تاخیری بر روی سیل اپیکالی دندان های درمان ريشه شده با دو سیلر متفاوت به روش نشت مايع
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بررسی تاثير استفاده از ابزارهای آموزشی مختلف بر سطح دانش کارکنان مدارس ابتدائی شهر قزوین در خصوص مدیریت صدمات تروماتيک دندانی
Get PDFThe antihelminthic drug, mebendazole, induces apoptosis in adult t-cell leukemia/lymphoma cancer cells: In-vitro trial
Get PDFBackground: Adult T-cell leukemia/lymphoma (ATLL) is a poor prognostic Hematopoietic malignancy with
various therapeutic challenges, which had been classified as non-Hodgkin lymphoma. The Drug switching, as a
novel, innovative and promising approach, is an opportunity to overcoming on therapeutic challenges of hardtreating disease, e.g. ATLL. Our aim is evaluating the antiproliferative and apoptotic effect of Mebendazole (MBZ)
on ATLL cancer cells in in-vitro conditions.
Materials and Methods: We used Jurkat cell-line as ATLL cancer cells. After treatment of MBZ in different
concentrations on jurkat cells, the cell viabilities were determined by MTT assay. After IC50 value determination,
the 24-, 48- and 72-h treatments had been performed in IC50 concentration and control to evaluating the
quantitative apoptosis rate by Annexin/PI Flowcytometry and qualitative apoptosis by DAPI Nuclear staining.
Also, Glucose spectrophotometry were performed to evaluate the reduced amount of glucose uptake through
MBZ treatment.
Results: MBZ inhibits proliferation of jurkat cells and IC50 value had been estimated 10 μM (P< 0.01). According
to the flowcytometric results, increasing in drug concentration is associated with decrease cell viability and the
percentage of full-apoptosis. However, it inversely correlates with percentage of early-apoptosis rate. Also, the
microscopic captures of DAPI Nuclear staining confirms the flowcytometry results in qualitative manner. In
addition, it was found that inhibition of glucose uptake was inversely correlated with increased MBZ
concentration (P< 0.05).
Conclusion: MBZ potentially inhibits the proliferation of ATLL cancer cells in in-vitro condition. MBZ inhibits the
growth of Jurkat cells by inducing apoptosis. Also, we suggest that indirectly inhibition of Glucose transporting
occurs by MBZ, which could induce apoptosis in cancer cells
NOL4 is Downregulated and Hyper-Methylated in Papillary Thyroid Carcinoma Suggesting Its Role as a Tumor Suppressor Gen
Get PDFBackground: Thyroid cancer is the fourth most common cancer in the world. Papillary thyroid carcinoma (PTC) accounts for 80%
of all types of thyroid neoplasm. Epigenetic alterations such as DNA methylation are known as the main cause of different types of
cancers through inactivation of tumor suppressor genes.
Objectives: In the present study, the expression and methylation of suggested gene namely nucleolar protein 4 (NOL4) in PTC in
comparison to multi nodular goiter (MNG) have been studied.
Methods: Forty-one patients with PTC and 38 patients affected by MNG were recruited. Thyroid tissues were obtained during thyroidectomy. RNA and DNA were extracted from thyroid tissues. Quantitative RT-PCR assay was performed for determining the mRNA
level of NOL4 while methylation-sensitive high resolution methylation was applied for assessing the methylation status with designing six pairs primers for six regions on gene promoter which were named from NOL4 (a) to NOL4 (f).
Results: Methylation assessment of 81 CpG islands in the promoter region of NOL4 gene revealed that NOL4 (f), the nearest region
to the start codon, was significantly hypermethylated in PTC cases compared to MNG cases. NOL4 level in PTC cases in comparison
with MNG cases were downregulated. The methylation status and mRNA level of NOL4 (f) were associated with age of diagnosis (Age
of the patient at the time of diagnosis), lymph node metastasis, and advanced stages of disease.
Conclusions: These data suggested an aberrant promoter hyper-methylation of NOL4 in PTC cases may be linked with its downregulation. Therefore, NOL4 gene can be proposed as a potential tumor suppressor gene in PTC tissues
Sorafenib and Mesenchymal Stem Cell Therapy: A Promising Approach for Treatment of HCC
Get PDFepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer and the second most common cause of cancer-related death worldwide. Sorafenib (Sora) is used as a targeted therapy for HCC treatment. Mesenchymal stem cells (MSCs) are applied as a new approach to fight malignancies. Drug resistance and side effects are the major concerns with Sora administration. The effect of using the combination of sorafenib and MSCs on tumor regression in xenograft HCC models was evaluated in this study. Methods and Materials. Human hepatocellular carcinoma cell lines (HepG2) were subcutaneously implanted into the flank of 18 nude mice. The animals were randomly divided into six groups (n = 3); each received Sora (oral), MSCs (IV injection), MSCs (local injection), Sora + MSCs (IV injection), Sora + MSCs (local injection), or no treatment (the control group). Six weeks after tumor implantation, the mice were scarified and tumoral tissues were resected in their entirety. Histopathological and immunohistochemical evaluations were used to measure tumor proliferation and angiogenesis. Apoptotic cells were quantified using the TUNEL assay. Results. No significant difference was found in the tumor grade among the treatment groups. Differentiation features of the tumoral cells were histopathologically insignificant in all the groups. Tumor necrosis was highest in the hpMSC (local) + Sora group. Tumor cell proliferation was reduced in hpMSC (local) + Sora-treated and hpMSC (IV) + Sora-treated mice compared with the other groups. Apoptotic-positive cells occupied a greater proportion in the Sora, hpMSC (IV) + Sora, and hpMSC (local) + Sora groups. Conclusion. A combination of chemotherapy and MSC can yield to more favorable results in the treatment of HCC
The branding process for healthcare centers: Operational strategies from consumer’s identification to market development
Get PDFMedical centers need branding approach to improve their position in patients’ minds. This study was carried out using mixed method. The participants included main experts, hospital managers and headquarters of the Ministry of Health. The data collection tool was a semi-structured interview and a researcher-made questionnaire. Branding process was conceptualized in 5steps, including Market Identification, Brand Identity, Brand Positioning, Development and Consolidation Strategy. All path coefficients were defined in the range. The results of the
indices showed that the fit was good and the final model was valid. The activities of Medical centers should be based on the identification of the target market. Unique services with new knowledge and equipment and experienced clinical staff to meet patients’ needs with appropriate price and quality have to be provided