Qazvin University of Medical Sciences
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Production of Bovine Collagen Hydrolysate with Antioxidant Activity; Optimized by Response Surface Methodology
Full text linkAbstract: Antioxidants are widely used in pharmaceutical industries. Gelatin is a byproduct of the
meat industry and its hydrolysates showed several functionalities, such as antioxidant activity. The
purpose of this study was to describe and optimize the enzymatic hydrolysis conditions including
time, temperature, pH, and enzyme/substrate ratio (E/S) to produce protein hydrolysate with
antioxidant functionality from bovine gelatin by RSM; the scavenging activity was evaluated using
the DPPH method. The model observed was fitted with desirable adequacy and sufficiency. We
found that the antioxidant activity increased significantly (p < 0.05) with the increase in pH value,
E/S ratio, and time of enzymatic process; however, the temperature had no significant (p < 0.05) effect
on the antioxidant activity of the hydrolysate. The optimum hydrolysis conditions were observed
at a temperature of 35.3 ◦C, pH of 8.0, and E/S ratio at 2.5 after 2 h hydrolysis by trypsin enzyme.
The results showed that the hydrolysate under these conditions, optimized by RSM, could be more
effective on antioxidant activity. Regarding the antioxidant potential, gelatin hydrolysate can be used
as an antioxidant supplement in pharmaceutical industries
Bacteriophages of Mycobacterium tuberculosis, their diversity, and potential therapeutic uses: a review
Full text linkTuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis) is a highly infectious disease and worldwide
health problem. Based on the WHO TB report, 9 million active TB cases are emerging, leading to 2 million deaths each
year. The recent emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis
(XDR-TB) strains emphasizes the necessity to improve novel therapeutic plans. Among the various developing antibacterial approaches, phage therapy is thought to be a precise hopeful resolution. Mycobacteriophages are viruses
that infect bacteria such as Mycobacterium spp., containing the M. tuberculosis complex. Phages and phage-derived
proteins can act as promising antimicrobial agents. Also, phage cocktails can broaden the spectrum of lysis activity
against bacteria. Recent researches have also shown the efective combination of antibiotics and phages to defeat the
infective bacteria. There are limitations and concerns about phage therapy. For example, human immune response
to phage therapy, transferring antibiotic resistance genes, emerging resistance to phages, and safety issues. So, in the
present study, we introduced mycobacteriophages, their use as therapeutic agents, and their advantages and limitations as therapeutic applications
طراحی مدل پیش بینی نیاز به تعداد تختهای بستری بیمارستانی برای بیماران مبتلا به COVID-19 با استفاده از مدلهای ANFIS و LSTM: یک واحد رابط کاربری گرافیکی (چکیده طرح هیأت علمی)
Full text linkAre health promoting lifestyles associated with pain intensity and menstrual distress among Iranian adolescent girls?
Full text linkObjective The present study investigated the relationship between a health-promoting lifestyle and menstrual pain
intensity and distress among adolescent girls in Qazvin.
Methods A cross-sectional survey study using a two-stage sampling method was conducted. The participants
(n = 986) were female high school students aged 14–19 years living in Qazvin. Random cluster sampling was used
to recruit participants from schools and classes from each grade. An online survey was provided to all participants
to complete. Data were collected using a Demographic and Menstrual Characteristics Checklist, the Visual Analogue
Scale (VAS) to assess dysmenorrhea intensity, the Andresh Milsom Scale (AMS) to assess dysmenorrhea severity, the
Moos Menstrual Distress Questionnaire (MMDS) to assess menstrual distress, and the Health-Promoting Lifestyle
Profile (HPLP) to assess a health promoting lifestyle. Data were analyzed using an univariable linear regression model
at a significance level of 0.05.
Results The findings indicated that 421 participants (42.7%) experienced dysmenorrhea with a mean duration of 2.24
days (SD = 1.57) and a mean pain intensity of 4.62 on the VAS (SD = 2.87). The mean score on the menstrual distress
on the MDDS was 13.55 (SD = 8.88) and the mean score on the HPLP was 2.55 (SD = 0.50). Based on the results of
univariable linear regression, nutrition (β=-0.18, p < 0.001) and exercise (β=-0.17, p < 0.001) had the most significant
effect on the severity of dysmenorrhea pain. Also, self-actualization (β=-0.29, p < 0.001), stress management (β=-0.25,
p < 0.001) and nutrition (β=-0.25, p < 0.001) had the most significant effect on menstrual distress.
Conclusion Based on these findings, it is suggested that (i) improving nutrition and exercise might reduce the
severity of dysmenorrhea pain and (ii) improving self-actualization, stress management and nutrition might reduce
the severity of menstrual distress. Overall, it seems that improving health-promoting lifestyle behaviors can help
improve the severity of dysmenorrhea pain and menstrual distress among adolescent girls
Binge-Watching and Mental Health Problems: A Systematic Review and Meta-Analysis
Full text linkAbstract: Background: Binge-watching, the viewing of online videos or streamed content, may be
associated with different types of mental health problems. The present study aimed to investigate
the associations between binge-watching and five mental health concerns including depression,
loneliness, sleep problems, anxiety, and stress. Methods: Academic databases of PubMed, Scopus,
Web of Science, ProQuest, PsycINFO, and Psych Articles were systematically searched through
February of 2022. The Newcastle–Ottawa Scale was used to assess the methodological quality. A
meta-analysis was performed on Fisher’s z values as effect sizes, using a random effect model.
Publication bias, small study effect, and moderators in this association were assessed. Results: Bingewatching
was significantly associated with the five types of mental health concerns with the most
robust correlations found with stress (0.32) and anxiety (0.25). Stronger associations between bingewatching
and two types of mental health problems (depression and sleep problems) were found
during the COVID-19 pandemic than before the pandemic. Moreover, stronger associations between
binge-watching and two types of mental health problems (stress and sleep problems) were found
in developing countries than in developed countries. Conclusions: The associations between bingewatching
and mental health concerns were significant and positive. Programs and interventions to
reduce binge-watching should be considered and tested
