Qazvin University of Medical Sciences
Qazvin University of Medical Sciences RepositoryNot a member yet
10283 research outputs found
Sort by
CRISPR-mediated modification of DNA methylation pattern in the new era of cancer therapy
Get PDFIn the last 2 decades, a wide variety of studies have been conducted on epigenetics and its role in various cancers. A major mechanism of epigenetic regulation is DNA methylation, including aberrant DNA
methylation variations such as hypermethylation and hypomethylation in the promoters of critical genes,
which are commonly detected in tumors and mark the early stages of cancer development. Therefore,
epigenetic therapy has been of special importance in the last decade for cancer treatment. In epigenetic
therapy, all efforts are made to modulate gene expression to the normal status. Importantly, recent studies have shown that epigenetic therapy is focusing on the new gene editing technology, CRISPR-Cas9.
This tool was found to be able to effectively modulate gene expression and alter almost any sequence in
the genome of cells, resulting in events such as a change in acetylation, methylation, or histone modifications. Of note, the CRISPR-Cas9 system can be used for the treatment of cancers caused by epigenetic
alterations. The CRISPR-Cas9 system has greater advantages than other available methods, including potent activity, easy design and high velocity as well as the ability to target any DNA or RNA site. In this
review, we described epigenetic modulators, which can be used in the CRISPR-Cas9 system, as well as their
functions in gene expression alterations that lead to cancer initiation and progression. In addition, we
surveyed various species of CRISPR-dead Cas9 (dCas9) systems, a mutant version of Cas9 with no endonuclease activity. Such systems are applicable in epigenetic therapy for gene expression modulation through
chemical group editing on nucleosomes and chromatin remodeling, which finally return the cell to the
normal status and prevent cancer progression
Efficacy of a Theory-Based Cognitive Behavioral Technique App-Based Intervention for Patients With Insomnia: Randomized Controlled Trial
Get PDF
Psychometric Properties of the Persian Generalized Trust Scale: Confirmatory Factor Analysis and Rasch Models and Relationship with Quality of Life, Happiness, and Depression
Get PDFTemporal associations between morningness/eveningness, problematic social media use, psychological distress and daytime sleepiness: Mediated roles of sleep quality and insomnia among young adults
Get PDFThe Mediating Effects of Eating Disorder, Food Addiction, and Insomnia in the Association between Psychological Distress and Being Overweight among Iranian Adolescents
Get PDFThe influence of climate change on the modeling of fire and explosion risk consequences in a City Gas Station (CGS)
Get PDFBackground and Aims: City gas stations have an important role in safety planning and crisis management. The
present study was aimed to investigate the effect of climate change on the fire and explosion hazard distance in
a CGS station at Qazvin in 2018.
Materials and Methods: In this study, eight dominant climatic conditions of study province were investigated.
The average of 3-year data in relation to atmospheric parameters was prepared from Qazvin Meteorological
Organization. The review of risk assessment studies of the target and similar stations in previous years was
followed by preparing topographic maps and process information. Then, the type and characteristics of the
possible scenario were determined and the consequences of fire and explosion risk were simulated using PHAST
software version 7.11. During the study, all ethical requirements were observed.
Results: Climate change was effective on the outcome of fire and explosion risk at the CGS station, so that
depending on the decreased and increased ambient temperature, the minimum (278.5 m) and maximum (321.321
m) flame length were obtained in winter and summer, respectively. In winter, the distance and danger zone
affected by the explosion was reduced to 686 m. Also in this season, the flame length increased and the danger
distance decreased to 9.4 m during day hours.
Conclusion: Increasing ambient air temperature, atmospheric stability, solar radiation flux, natural gas flow rate
and the increased natural gas pressure inside the pipeline results in increased affected distance around the station.
On the other hand, the increased relative humidity would cause to reduce the affected distance around the station
The Effect of a Midwife-Based Group Discussion Education on Sexual Dysfunction Beliefs in Rural Postmenopausal Women
Get PDFIncidence and risk factors for medical device-related pressure ulcers: The first report in this regard in Iran
Get PDFFew studies, especially among developing countries such as Iran, have been
conducted on the incidence and risk factors for medical device-related pressure
ulcers (MDRPUs). Given the importance of this issue and the lack of previous
studies, the present study aimed to investigate the incidence and risk factors
for MDRPUs in Iran. The present descriptive-analytical study was conducted
at three hospitals in Qazvin, Iran, from June 1, 2019, to September 1, 2019.
Data collection took approximately 3 months from July to September 2019.
Sampling was carried out through a convenience sampling method, and the
samples consisted of 404 patients. For data collection, a checklist for demographic variables, a checklist for patient-connected medical devices, Braden
Scale, Glasgow Coma Scale, National Pressure Ulcer Advisory Panel Pressure
Grading Scale, and Nutrition Risk Screening 2002 were used. Of the
404 patients studied, 20.54% (n = 83) developed some degree of MDRPUs.
From those, 61 (70.11%) were in stage I, 17 (19.5%) were in stage II, and
9 (10.34%) were in stage III. Among the nine medical devices that caused pressure ulcers, the most commonly reported ones were nasal oxygen tubes
(31 cases), oxygen face masks (23 cases), and endotracheal tubes (17 cases).
The mean score of Braden Scale (P = .004), the mean score of NRS 2002 (P
= .037), older age (P = .007), male gender (P = .002), the average length of stay
in hospitals (P = .001), and having pressure ulcers in body (P = .025) significantly increased the possibility of occurring MDRPUs. In the present study,
the incidence of MDRPUs was high. Taking the necessary measures into consideration in order to prevent the MDRPUs is essential in Iranian hospitals.
Further studies in this regard are strongly recommended