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Immunoinformatics and molecular dynamics studies to predict T-cell-specific epitopes of four Klebsiella pneumoniae fimbriae antigens
Get PDFKlebsiella pneumoniae (K. pneumoniae) is a causative agent of severe infections in humans. There is no
publically available vaccine for K. pneumoniae infections yet. Here, using comprehensive immunoinformatics methods, T-cell-specific epitopes of four type 1 fimbriae antigens of K. pneumoniae were predicted and evaluated as potential vaccine candidates. Both CD8þ (class I) and CD4þ (class II) T-cellspecific epitopes were predicted and the epitopes similar to human proteome were excluded.
Subsequently, the windows of class-II epitopes containing class-I epitopes were determined. The
immunogenicity, IFN-c production and population coverage were also estimated. Using the 3D structure of HLA and epitopes, molecular docking was carried out. Two best epitopes were selected for
molecular dynamics studies. Our prediction and analyses resulted in the several dominant epitopes for
each antigen. The docking results showed that all selected epitopes can bind to their restricted HLA
molecules with high affinity. The molecular dynamics results indicated the stability of system with minimum possible deviation, suggesting the selected epitopes can be promising candidates for stably
binding to HLA molecules. Altogether, our results suggest that the selected T-cell-specific epitopes of
K. pneumoniae fimbriae antigens, particularly the two epitopes confirmed by molecular dynamics, can
be applied for vaccine development. However, the in vitro and in vivo studies are required to authenticate the results of the present study
Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials
Get PDFThe aim of this systematic review and meta-analysis was to evaluate the effects of
Nigella sativa (N. sativa) on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Two independent authors systematically examined
online databases consisting of, EMBASE, Scopus, PubMed, Cochrane Library, and
Web of Science from inception until October 30, 2019. Cochrane Collaboration risk
of bias tool was applied to assess the methodological quality of the studied trials. The
heterogeneity among the included studies were assessed using the Cochrane's Q test
and I-square (I
2
) statistic. Data were pooled using a random-effects model and
weighted mean difference (WMD) was considered as the overall effect size. A total
of 50 trials were included in this meta-analysis. We found a significant reduction in
total cholesterol (WMD: −16.80; 95% CI: −21.04, −12.55), triglycerides (WMD:
−15.73; 95% CI: −20.77, −10.69), LDL-cholesterol (WMD: −18.45; 95% CI: −22.44,
−14.94) and VLDL-cholesterol (WMD: −3.72; 95% CI: −7.27, −0.18) following supplementation with N. sativa. In addition, there was significant reductive effect
observed with N. sativa on fasting glucose (WMD: −15.18; 95% CI: −19.82, −10.55)
and HbA1C levels (WMD: −0.45; 95% CI: −0.66, −0.23). Effects of N. sativa on CRP
(WMD: −3.61; 95% CI: −9.23, 2.01), TNF-α (WMD: −1.18; 95% CI: −3.23, 0.86),
TAC (WMD: 0.31; 95% CI: 0.00, 0.63), and MDA levels (WMD: −0.95; 95% CI:
−2.18, 0.27) were insignificant. This meta-analysis demonstrated the beneficial
effects of N. sativa on fasting glucose, HbA1c, triglycerides, total-, VLDL-, LDLcholesterol levels
Examining the effect of a brief psychoeducation intervention based on self-regulation model on sexual satisfaction for women with breast cancer: A randomized controlled trial
Get PDFPurpose: The main goal of this study was to investigate whether the Self-Regulation Model could improve sexual satisfaction for women diagnosed with breast cancer. Methods: Adult women diagnosed with breast cancer were recruited from a hospital in Qazvin, Iran. Participants were randomly assigned to either an intervention group (n = 40) or a control group (n = 40). All participants were administered a demographic questionnaire and an Index of Sexual Satisfaction (ISS) pre-intervention, immediately post-intervention, and 1, 2, and 3 months following the intervention. The control group completed the assessments along the same time line as the intervention group. Women in the experimental group were provided three sessions of a psychological individual intervention which included psychoeducation regarding their diagnosis and personalized intervention strategies to improve their overall sexual satisfaction with sexual intercourse. Each intervention took between 60 and 90 min to administer. Results: The experimental and control group participants were well balanced in terms of demographic characteristics and sexual satisfaction scores before the intervention. The intervention group showed a positive increasing trend in the sexual satisfaction scores over time while the control group participants had a negative trend (p < 0.05). There were also statistical differences in the sexual satisfaction scores at each follow-up month (p < 0.05) adjusted for the baseline score and relevant demographical variables, showing longer term effects with a significant increase in sexual satisfaction over time. Conclusion: Providing a psychoeducational based intervention provided an increase of sexual satisfaction during intercourse for women diagnosed with breast cancer. The psychoeducation based intervention provided an opportunity for participants to dispel common myths regarding their disease and obtain new strategies and skills to improve their sexual satisfaction from intercourse with their partners
The Association of Sleep Quality with Dietary Intake and Rate of General and Central Obesity among Young Female Students in Qazvin City, Iran
Get PDFBackground: Insufficient sleep duration and unhealthy diet are associated with
weight gain. However, little is known about the association of sleep quality
with dietary intake and obesity. The aim of the present study was to compare
dietary intake and anthropometric indices between good and poor sleepers.
Methods: In this cross-sectional study, a total of 260 females youth aged 18-30
years were recruited among the students of Qazvin University of Medical
Sciences. The evaluated variables consisted of sleep quality, dietary intake, and
anthropometric indices. Statistical analysis was performed using SPSS version
21.0. Results: Participants in the poor quality sleep group had higher intakes of
calorie (P < 0.001) and carbohydrate (P < 0.001), and lower protein intake
(P < 0.01) in comparison with good sleepers. Regarding food groups, poor
sleepers had higher intake of bread-grains (P = 0.02) group, but lower intake of
meat-alternatives (P < 0.001), vegetables (P < 0.001), and fruits (P < 0.001) in
comparison with the good sleepers. Participants in the poor quality sleep group
had higher weight (P < 0.001), body mass index (P < 0.001), waist
circumference (P < 0.001), and fat mass (P < 0.001) in comparison with good
sleepers. Conclusion: Our findings emphasize the relationship of poor quality
sleep with unhealthy dietary intake and obesity in young female women
Performing percutaneous dilational tracheostomy without using fiberoptic bronchoscope
Get PDFBackground: Percutaneous tracheostomy is an elective method that is
increasingly being taken up in the intensive care unit alongside the patient's
bed. In many centers, bronchoscopy is used, but the necessity of using
bronchoscopy in percutaneous tracheostomy has not yet been determined.
Discontinuing use of bronchoscopy can potentially reduce the cost and increase
the efficiency of percutaneous tracheostomy. Therefore, in this study, we
performed a percutaneous dilatational tracheostomy without using fiberoptic
bronchoscopy.
Materials and Methods: This study was performed as a descriptive
epidemiological survey among 70 patients in Shahid Rajaei Hospital of Qazvin
in 2015 and 2016. The results were assessed in the patients.
Results: In this study, pneumothorax, trauma, major and minor bleeding, cuff
leak and change to surgical procedures as well as accidental extubation were
not seen. However, subcutaneous emphysema, mal-position and hypoxia each
were seen in one patient (1.4%).
Conclusion: Totally the results demonstrated that percutaneous dilatation
tracheostomy without fiberoptic bronchoscopic guidance is useful and saf
Royal jelly Accelerate healing of acetate induced gastric ulcer in male rats
Get PDFAim: This study examined the healing potential of royal jelly on the acetic acid induced wounds healing in male rat’s gastric mucosa.
Background: Scientific reports suggest that, bee products can help in the wounds healing.
Methods: 96 adult male Wistar rats were divided into in 4 groups as follows: control, omeprazole 20 mg/kg, and royal jelly 50 and
200 mg/kg). Wound was induced in stomach mucosa of each rat with 100% acetic acid. Samples groups received omeprazole or royal
jelly from 1st to 14th day after acetic ulcer induction. Gastric ulcer healing and histopathological parameters were evaluated on 4, 7,
10, 15th days after ulceration. Both descriptive and statistical analyses were used. P <0.05 was considered as significant.
Results: The royal jelly administration significantly reduced the depth of lesion in comparison with the control group (p<0.05) and
attuned histopathological changes in the treatment groups. The largest healing effect was demonstrated with royal jelly on 10th
treatment day, at a higher concentration (200 mg/kg).
Conclusion: These findings supported that royal jelly had effectively contributed to the wound healing, valid gastroprotective
activity, and can be used for peptic ulcer therapy
ارزیابی تاثیر شیشه زیست فعال 68S جایگزین شده با لیتیم به روش سل ژل بر روی توانایی تمایز و مینرالیزاسیون سلول های بنیادی پالپ دندان انسانی در شرایط آزمایشگاهی
Get PDFبررسی دانش، نگرش، نیازها و چالش های اعضا هیئت علمی دانشکده دندانپزشکی قزوین در خصوص آموزش مجازی
Get PDFMolecular identification of Echinococcus granulosus sensu lato by mitochondrial COX1 and SSU-rDNA markers in dogs in the west of Iran
Get PDFEchinococcus granulosus sensu lato (E. granulosus s. l.) is important in terms of the medical and veterinary sciences, especially in the tropical and subtropical regions. Stray and domestic dogs are the most important definitive hosts for this parasite. The aim of this study was to determine the prevalence of E. granulosus s. l. among stray and domestic dogs using copro-nested PCR method in the west of Iran. Accordingly, 605 faecal samples of domestic (n = 424) and stray (n = 181) dogs were collected from Kermanshah (n = 301) and Lorestan (n = 304) Provinces, in the west of Iran. Initially, the samples were concentrated using formalin-ether method and the precipitates were collected for further examination using copro-PCR method using COX1 and SSU-rDNA markers in order to detect taeniid parasites and E. granulosus s. l., respectively. Totally, taeniid parasites were observed in 38 (6.28%) samples, of which 21 (3.47%) samples in domestic dogs and 17 (2.8%) samples in stray dogs were detected. Moreover, of 38 taeniid positive samples, 21 (3.47%) samples were positive for E. granulosus s. l that 13 (2.14%) samples in domestic dogs and 8 (1.32%) samples in stray dogs were detected. In conclusion, the findings of the current study specified that the overall prevalence of echinococcosis was low (3.47%) in domestic and stray dogs in the examined areas. Since western Iran is one of the areas with high potential for transmission of E. granulosus s. l., regular monitoring of the prevalence of this disease in both the final hosts and the intermediate hosts is important at regular intervals
The acoustic performance of 3D printed multiple jet nozzles with different configurations
Get PDFAbstract: This work investigated multiple jet nozzles with various geometrical
shape, number of exits, and material on reducing noise radiated from jet flows.
Nozzles are categorized in two groups with few and many exit numbers, each
with various exit shapes, slot and circular, and geometry. Firstly, nozzles are
designed and then fabricated by a 3D printer, Form Labs, Form2USA, with polymeric resin. Also, the nozzle with the most noise reduction made of stainless steel.
Noise and air thrust were measured at three air pressure gauges, 3, 5, 7 BAR
and directions from nozzle apex, 30°, 90°, 135°. Nozzles with slot exit shape
made of both plastic and stainless steel revealed the most noise reduction among
all nozzles with few exit numbers, nearly 11–14 dB(A) and 11.5–15 dB(A),
respectively. On average, slotted nozzle noise reduction was nearly 5–6 dB(A)
more than finned nozzle. However, nozzles with more exit numbers, finned and
finned-central exit, illustrated much more noise reduction than nozzles with few exit
numbers, by almost 16–18 dB(A), they represented similar sound. All tested nozzles
and open pipe demonstrated equal air thrust at each pressure gauges. The nozzles
with slotted exit shape, either plastic or stainless steel, can provide reasonable noise
reduction in comparison to other configuration with few exit numbers. In contrast,
nozzles with more exit numbers demonstrated the most noise reduction