Qazvin University of Medical Sciences
Qazvin University of Medical Sciences RepositoryNot a member yet
10283 research outputs found
Sort by
Thyroid dysfunction in children with idiopathic nephrotic syndrome attending a paediatric hospital in Qazvin, Iran
Get PDFabstract: Objectives: Nephrotic syndrome is a glomerular disease characterised by a loss of albumin and
high-molecular-weight proteins such as thyroxine-binding globulin and thyroid hormones, potentially resulting
in subclinical or even overt hypothyroidism. This study aimed to compare thyroid hormone levels between
nephrotic children and healthy controls as well as between nephrotic children in the active phase of the disease
and those in remission. Methods: This case-control study was conducted between March 2016 and 2018
at a paediatric hospital in Qazvin, Iran. A total of 73 nephrotic children comprised the case group—including
49 with active disease and 24 in remission—while the control group included 74 healthy children. Thyroid
function was assessed according to levels of thyroid-stimulating hormone (TSH), free triiodothyronine (T3),
free thyroxine (T4), total T4, total T3 and anti-thyroid peroxidase. Results: All of the controls had normal
total T4 levels. Elevated TSH levels were more frequent in nephrotic children compared to controls (34.2%
versus 10.8%; P = 0.001). A significantly lower number of patients with active disease were euthyroid compared
to those in remission (51% versus 95.8%; P = 0.001). Moreover, 7 (9.5%) of patients in the active and no patient
in remission phase had abnormal total T4 levels (P <0.001), while 14.3% and 0% had highly elevated TSH levels
(P = 0.002). Conclusion: Due to the prevalence of subclinical and even overt hypothyroidism, thyroid screening
tests may be required for nephrotic children. However, further research is needed to confirm these findings
Front-line staff's perspective on patient safety culture in Iranian medical centers: A systematic review and meta-analysis
Get PDFBACKGROUND: The prerequisite for promoting safety culture is to assess the existing
safety culture level of institutes, because safety precautions without appropriate evaluation
increase costs and unforeseen risks. OBJECTIVE: This study aimed to systematically review the
status of patient safety culture from the perspective of clinical personnel at Iranian hospitals
through a meta-analysis of studies using the Hospital Survey on Patient Safety Culture (HSOPSC)
questionnaire. METHODS: The present systematic review and meta-analysis was conducted in
2018. Data were gathered by searching Google Scholar, Scopus, PubMed, and Web of Science
databases up to November 2018. Search keywords were “patient”, “safety”, “culture”,
“healthcare”, “hospital”, “medical center”, “HSOPSC tool”, and “Iran”. The search protocol was
limited to 10 years. To estimate the PSC score, computer software CMA:2 (Comprehensive MetaAnalysis) was used. The presence of heterogeneity across the studies was assessed with the I2
statistic. A forest plot was used to report the results. Publication bias was assessed through a funnel
plot. RESULTS: The meta-analysis of studies showed that the PSC score based on the random
effect model was 52.7% (95% CI: 50.2%–55.2%), (Q = 522.3, df = 54, P < 0.05, I2 = 89.6). A
mean of 12 dimensions of HSOPSC showed that the “Teamwork within units” dimension had the
highest PSC score (67.2%) and “Non-punitive response to error” had the lowest score (40.4%).
CONCLUSIONS: Managers and policymakers should be directed towards non-punitive responses
to errors and persuade staff to report errors and execute the approach to learn from mistakes. Also,
a periodic government evaluation of the patient safety culture will help further its sustainable
development
Royal jelly accelerates healing of acetate induced gastric ulcers in male rats
Get PDFAim: This study examined the healing potential of royal jelly on the acetic acid induced wounds healing in male rat’s gastric mucosa.
Background: Scientific reports suggest that, bee products can help in the wounds healing.
Methods: 96 adult male Wistar rats were divided into in 4 groups as follows: control, omeprazole 20 mg/kg, and royal jelly 50 and
200 mg/kg). Wound was induced in stomach mucosa of each rat with 100% acetic acid. Samples groups received omeprazole or royal
jelly from 1st to 14th day after acetic ulcer induction. Gastric ulcer healing and histopathological parameters were evaluated on 4, 7,
10, 15th days after ulceration. Both descriptive and statistical analyses were used. P <0.05 was considered as significant.
Results: The royal jelly administration significantly reduced the depth of lesion in comparison with the control group (p<0.05) and
attuned histopathological changes in the treatment groups. The largest healing effect was demonstrated with royal jelly on 10th
treatment day, at a higher concentration (200 mg/kg).
Conclusion: These findings supported that royal jelly had effectively contributed to the wound healing, valid gastroprotective
activity, and can be used for peptic ulcer therapy
بررسی تاثیر حساسیت¬زدایی با حرکات چشم و پردازش مجدد بر اضطراب مرگ بیماران دارای سرطان دستگاه گوارش در بیمارستان ولایت قزوین در سال 1397
Get PDF
ارزیابی آزمایشگاهی دونوع فایل روتاری Race file, Kedo S در مقایسه با فایل دستی در آماده سازی کانال ریشه دندانهای مولر شیری
Get PDFMolecular mechanisms and prevalence of colistin resistance of Klebsiella pneumoniae in the Middle East region: A review over the last 5 years
Get PDFThe increasing prevalence of multidrug-resistant (MDR) Klebsiella pneumoniae is a serious clinical
and public health problem, and colistin is the last-resort treatment option for MDR infections. However,
resistance to colistin has been increasingly reported in the world, such as the Middle East region, where
antibiotics are used more in the human and agriculture industry. In this paper, we review the available
data on the molecular mechanisms and prevalence of colistin resistance of K. pneumoniae in the Middle
East over the last 5 years. To the best of our knowledge, 590 colistin-resistant K. pneumoniae isolates
were reported from six countries, including Turkey (438), Iran (86), Saudi Arabia (24), United Arab
Emirates (31), Kuwait (5), Israel (3) and Lebanon (3), between 2013 and 2018. However, there has been no
reports about colistin resistance among K. pneumoniae isolates in Iraq, Yemen, Syria, Jordan, Palestine,
Oman, Qatar, Bahrain and Cyprus. Moreover, it seems that mutations and insertion sequence
transpositions in the mgrB gene were the most common colistin resistance mechanisms among K.
pneumoniae in the Middle East region, which is similar to other parts of the world
