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بررسی حساسیت و ویژگی سونوگرافی داپلر در کودکان مبتلا به پیلونفریت حاد در تشخیص اسکار کلیه در مقایسه با اسکن دیمرکاپتوسوکسینیک اسید
Get PDFزمینه و هدف :عفونت ادراري کودکان میتواند باعث آسیب برگشتناپذیر کلیه شود. استاندارد تشخیصی براي آسیب کلیه
اسکن ديمرکاپتوسوکسینیک اسید است. سونوگرافی داپلر بهعنوان روش کمتر تهاجمی مطرح شده است. هدف مطالعه
حاضر تعیین حساسیت و ویژگی سونوگرافی داپلر در تشخیص اسکار کلیه در کودکان با سابقه پیلونفریت حاد میباشد.
روش بررسی: در این مطالعه مقطعی، 120 کودك شش ماهه تا 12 ساله مبتلا به پیلونفریت حاد از شهریور 1396 تا
1397 در بیمارستان کودکان قزوین بررسی شدند. اسکن ديمرکاپتوسوکسینیک اسید در زمان عفونت حاد انجام شد.
نیمی از بیماران کاهش جذب ماده ایزوتوپ در پارانشیم کلیه را داشتند، که براي این بیماران شش ماه پس از آن اسکن
کلیه تکرار شد و 30 بیمار در اسکن دوم اسکار کلیه داشتند. بیماران مبتلا به اسکار کلیه تحت سونوگرافی داپلر عروق
کلیه قرار گرفتند و خونرسانی به کلیهها در نواحی مختلف هر کلیه بررسی شد. 20 بیمار با اسکن طبیعی و سابقه
پیلونفریت حاد در همان مقطع زمانی وارد مطالعه شدند و سونوگرافی داپلر براي آنان نیز انجام شد.
یافتهها: فراوانی اسکار کلیه در بیماران مورد مطالعه براساس اسکن کلیه 60 % و براساس سونوگرافی داپلر 14 % بود.
23 و 100 % گزارش شد. ارزش اخباري مثبت و / حساسیت و اختصاصیت سونوگرافی داپلر در بررسی اسکار کلیه برابر 3
46 % بود. / منفی سونوگرافی داپلر در بررسی وجود اسکار کلیه در کودکان با سابقه ابتلا به پیلونفریت حاد برابر 100 و 5
نتیجهگیري: حساسیت و ارزش اخباري منفی سونوگرافی داپلر در بررسی اسکار کلیه در کودکان با سابقه ابتلا به
عفونت مجاري ادراري پایین بود.
کلمات کلیدي: بیماري حاد، کودکان، عوارض، پیلونفریت، تصویربرداري رادیونوکلیید
Effect of Edible Coating containing Probiotic Bacteria on the Quality Characteristics and Storage Stability of Cooked Cured Chicken Breast Meat during Refrigerated Storage
Get PDFEarly Hemoperfusion for Cytokine Removal May Contribute to Prevention of Intubation in Patients Infected with COVID-19
Get PDFHemoperfusion (HP) was helpful to prevent the development and progression of acute respiratory distress syndrome
(ARDS), acute kidney injury (AKI), liver failure, and septic
shock by removing cytokines and other inflammatory mediators and ultimately preventing progression toward multiple organ failure. A 54-year-old man diagnosed with COVID-19 was hospitalized in the intensive care unit. The patient’s O2 saturation was 80% using an oxygen mask, which
was gradually declining. After 4 sessions of HP/continuous
renal replacement therapies (CRRT), O2 saturation reached
to 95%, and the patient was transferred to the general ward.
Performing HP/CRRT at the early stages of ARDS can obviate
the need for intubating patients with COVID-19. Punctual
and early use of HP and CRRT in the treatment of ARDS in
patients with COVID-19 prevented the progression of ARDS
and patient intubation, reduced respiratory distress and the
patient’s dependence on oxygen, prevented other complications such as AKI and septic shock in the patient, and reduced mortality and hospital length of stay
Computational Modeling and Analysis to Predict Intracellular Parasite Epitope Characteristics Using Random Forest Technique
Get PDFBackground: In a new approach, computational methods are used to design and evaluate the vaccine. The aim
of the current study was to develop a computational tool to predict epitope candidate vaccines to be tested in
experimental models.
Methods: This study was conducted in the School of Allied Medical Sciences, and Center for Research and
Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran in 2018. The random
forest which is a classifier method was used to design computer-based tool to predict immunogenic peptides.
Data was used to check the collected information from the IEDB, UniProt, and AAindex database. Overall, 1,264
collected data were used and divided into three parts; 70% of the data was used to train, 15% to validate and 15%
to test the model. Five-fold cross-validation was used to find optimal hyper parameters of the model. Common
performance metrics were used to evaluate the developed model.
Results: Twenty seven features were identified as more important using RF predictor model and were used to
predict the class of peptides. The RF model improves the performance of predictor model in comparison with
the other predictor models (AUC±SE: 0.925±0.029). Using the developed RF model helps to identify the most
likely epitopes for further experimental studies.
Conclusion: The current developed random forest model is able to more accurately predict the immunogenic
peptides of intracellular parasites
Evolving evidence on a link between the ZMYM3 exceptionally long GA‑STR and human cognition
Get PDFThe human X-linked zinc fnger MYM-type protein 3 (ZMYM3) contains the longest GA-STR identifed
across protein-coding gene 5′ UTR sequences, at 32-repeats. This exceptionally long GA-STR is located
at a complex string of GA-STRs with a human-specifc formula across the complex as follows: (GA)8(GA)4-(GA)6-(GA)32 (ZMYM3-207 ENST00000373998.5). ZMYM3 was previously reported among the
top three genes involved in the progression of late-onset Alzheimer’s disease. Here we sequenced the
ZMYM3 GA-STR complex in 750 human male subjects, consisting of late-onset neurocognitive disorder
(NCD) as a clinical entity (n= 268) and matched controls (n= 482). We detected strict monomorphism
of the GA-STR complex, except of the exceptionally long STR, which was architecturally skewed
in respect of allele distribution between the NCD cases and controls [F (1, 50)= 12.283; p= 0.001].
Moreover, extreme alleles of this STR at 17, 20, 42, and 43 repeats were detected in seven NCD
patients and not in the control group (Mid-P exact= 0.0003). A number of these alleles overlapped
with alleles previously found in schizophrenia and bipolar disorder patients. In conclusion, we propose
selective advantage for the exceptional length of the ZMYM3 GA-STR in human, and its link to a
spectrum of diseases in which major cognition impairment is a predominant phenotype
ارزیابی آمادگی بیمارستان های شهر اهواز در جذب گردشگران سلامت: رویکرد استانداردهای کمیسیون مشترک بین الملل JCI
Get PDFOsteopontin sirna does not confer resistance to toxic effects of parthenolide in jurkat cells
Get PDFBackground: Osteopontin (OPN) plays a critical role in cell proliferation and drug resistance in cancer treatment and hematological
malignancies. In T cell acute lymphoblastic leukemia, most initial therapies can induce remission while some patients then relapse
and do not respond well to chemotherapy. The sesquiterpene lactone parthenolide (PTL) can induce apoptosis in a variety of cancer cell lines via inhibition of pro-inflammatory transcription factor nuclear factor kappa B and has anti-tumor activity in acute
lymphoblastic leukemia treatment. Aim: To study the role of OPN in conferring in vitro resistance to PTL in Jurkat cells. Methods:
Jurkat cells were cultured with 8–20 μm PTL for 48 h. Transfection with OPN siRNA was provided. Apoptosis assays were performed with Annexin V-Alexa Fluor-488/PI. Quantitative real-time polymerase chain reaction was used to measure OPN gene
expression using the 2-2-ΔΔCt method. Results: PTL has cytotoxic and apoptotic effect on Jurkat cells with IC50 values of 16.1 μm,
and growth inhibition effect of PTL does not differ significantly in combination with OPN-siRNA. OPN gene expression is not
affected by PTL. Conclusions: Parthenolide induces apoptosis in Jurkat cells, but inhibition of osteopontin gene expression with
siRNA does not reduce apoptotic effect of parthenolide
Effects of Benson's relaxation technique on occupational stress in midwives
Get PDFPurpose: To examine the effect of Benson’s relaxation technique on occupational stress in midwives working in a Labor and Delivery (L&D) unit.
Methods: This pre- and post-quasi-experimental study involved 65
midwives with a minimum 1 year of experience using convenience sampling. After training, the participants performed Benson’s relaxation technique twice a day for 4 weeks.
Results: Occupational stress was measured using standard questionnaires of occupational stress. Data were analyzed using the Statistical
Package for Social Sciences software. Statistical analysis was performed
using the Kolmogorov-Smirnov goodness-of-fit test, Student’s t-test, and
Wilcoxon signed rank test.
Conclusion: This study demonstrated that Benson’s relaxation technique
may be effective in reducing occupational stress among midwives in
L&D units