Qazvin University of Medical Sciences
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In Vitro Transportation of Curved Canals Following Glide Path Preparation by Path File and Scout RaCe Rotary Systems versus Manual Instrumentation Using Cone-Beam Computed Tomography
Get PDFتأثیر مکمل یاری تورمریک در ترکیب با مفنامیک اسید در مقایسه با دارونما در دختران مبتلا به دیسمنوره اولیه؛ کار آزمایی بالینی تصادفی، دو سوکور، کنترلشده با دارونما(چکیده طرح تحقیقاتی)
Get PDFبررسی الگوی متیلاسیون پروموتر ژن PTEN در بیماران مستعد ترمبوز ) Hyper coagulable state ( با روش PCR اختصاصی متیلاسیون
Get PDFInduced Pluripotent Stem Cell Meets Severe Combined Immunodeficiency
Get PDFSevere combined immunodeficiency (SCID) is classified as a primary immunodeficiency, which is characterized by impaired
T-lymphocytes differentiation. IL2RG, IL7Ralpha, JAK3, ADA, RAG1/RAG2, and DCLE1C (Artemis) are the most defective
genes in SCID. The most recent SCID therapies are based on gene therapy (GT) of hematopoietic stem cells (HSC), which
are faced with many challenges. The new studies in the field of stem cells have made great progress in overcoming the
challenges ahead. In 2006, Yamanaka et al. achieved "reprogramming" technology by introducing four transcription factors
known as Yamanaka factors, which generate induced pluripotent stem cells (iPSC) from somatic cells. It is possible to apply
iPSC-derived HSC for transplantation in patients with abnormality or loss of function in specific cells or damaged tissue, such
as T-cells and NK-cells in the context of SCID. The iPSC-based HSC transplantation in SCID and other hereditary disorders
needs gene correction before transplantation. Furthermore, iPSC technology has been introduced as a promising tool in
cellular-molecular disease modeling and drug discovery. In this article, we review iPSC-based GT and modeling for SCID
disease and novel approaches of iPSC application in SCID
A theory-based intervention delivered by an online social media platform to promote oral health among Iranian adolescents: a cluster randomized controlled trial
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