Qazvin University of Medical Sciences
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Concurrence of Primary Cutaneous Extra Mammary Paget’s Disease and Squamous Cell Carcinoma in situ of Vulva: A Case Report
Get PDFEvaluation of Thyroid Dysfunction in Women with Gestational Diabetes Mellitus Compared to Healthy Pregnant Women Referred to Kowsar Hospital in Qazvin from 2017 to 2018
Get PDFمطالعه خواص میکروبیولوژیکی، فیزیکوشیمیایی و حسی پنیر پروسس فرآوری شده با پودر فلفل سیاه
Get PDFچکیده
زمینه و هدف: گرایش اخیر در تولید پنیر، تولید پنیر طعم دار شده به وسیله مواد طعم دارکننده طبیعی، با ارزش غذایی بالا و همچنین کیفیت بالای میکروبی جهت مصرف انسان می باشد. هدف از انجام این تحقیق، بررسی خواص میکروبیولوژیکی، فیزیکوشیمیایی و حسی پنیر پروسس فلفلی می باشد.
مواد و روش کار: ابتدا یک آزمون حسی برای درصدهای مختلف فلفل به صورت آزمون هدونیک 5 نقطهای در پنل حسی انجام و مناسبترین درصد از نظر مقبولیت بین مصرفکنندگان انتخاب شد. نمونه ها پس از تولید با استفاده از درصد فلفل انتخاب شده در سه دمای 6، 25 و 37 درجه سلسیوس نگهداری شدند. بلافاصله پس از تولید و همچنین پس از گذشت هر یک ماه از تاریخ تولید تا 4 ماه و یک ماه پس از تاریخ انقضا مورد ارزیابی میکروبی، فیزیکوشیمیایی و حسی قرار گرفتند. انجام آزمون به همراه یک نمونه شاهد پنیر پروسس بدون پودر فلفل بود. طرح مورد استفاده، طرح فاکتوریل و شامل 3 تکرار برای هر تیمار بوده و دادههای مورد نظر با بهره گيري از نرم افزار SPSS و آزمون آنالیز واریانس و Student’s T-Test مورد بررسی قرار گرفتند. سطح معنی داری در پژوهش حاضر کمتر از 05/0 درصد بود.
یافته ها: نتایج به دست آمده از آنالیز های شیمیایی پنیر فلفی در مقایسه با شاهد نشان داد که پنیر فلفلی از لحاظ pH، ماده خشک و بافت از تغییرات کمتری در طول زمان گرمخانه گذاری نسبت به شاهد برخوردار بوده و از لحاظ میکروبی دارای میزان کمتری از باکتریها بوده و همچنین از لحاظ پذیرش کلی پنیر فلفلی تفاوت معنی داری نسبت به شاهد نداشت.
نتیجه گیری: نتایج به دست آمده نشان داد که پنیر فلفلی توانسته است کیفیت خود را در مقابل پنیر شاهد در تیمار های زمانی و دمایی مختلف اعمال شده با کنترل بهتر تغییرات فاکتورهای شیمیایی و میکروبی حفظ کند تا کیفیت محصول را با جلوگیری از افت کمتر کیفیت تضمین نماید
The Effect of Anxiety Caused by the COVID-19 Pandemic on Domestic Violence Against Pregnant Women
Get PDFThe role of interleukin 4 and IL-4RA in intervertebral disc degeneration: investigation of single nucleotide polymorphisms in genes and a systematic review & meta-analysis of IL-4 expression level
Get PDFBackground: Intervertebral disc degeneration (IVDD) is a multifactorial disease that is
sensitive to the balance between anti-inflammatory and pro-inflammatory cytokines. This
study investigated the single nucleotide polymorphisms (SNPs) of interleukin 4 (IL-4) in
IVDD. Methods: Genomic DNA of peripheral mononuclear cells of 76 IVDD patients and 140
healthy controls were investigated for three SNPs of IL-4 (rs2243248 (−1098G/T), rs2243250
(−590 C/T), rs2070874 (−33 C/T)) and 1 SNP of IL-4RA (rs180275, +1902 A/G) through PCRSSP method. Results: The ‘C’ allele frequency of IL-4 rs2243250 was 104 in 76 patients, while
it was 149 in 140 controls (OR = 2, p =.001); also this SNP was significantly associated with
post-operative pain reduction. The ‘C’ allele of IL-4 rs2070874 (130 in 76 patients, and 200 in
140 controls, OR = 2.66), and the ‘CC’ genotype were more frequent among patients (OR =
3.98, p <.001) than controls. ‘TTT’ haplotype was more common in controls (OR = 0.36, p
<.001) and ‘TCC’ was also more common in patients (OR = 1.75, p =.012). A meta-analysis
of previous studies found significantly higher IL-4 levels in disc tissues of IVDD patients,
which was not similarly found in blood samples. Conclusion: The immune system plays an
important role in IVDD. The extent and progress of the disease vary significantly with IL-4
level. Meanwhile, the rs2070874 and rs2243250 SNPs of IL-4 were significantly associated
with IVDD in Iranian patients.
Keywords: Intervertebral disc degeneration, single nucleotide polymorphism, interleukin 4,
Interleukin-4 receptor alpha, immunogenetics, cytokin
β-radiating radionuclides in cancer treatment, novel insight into promising approach
Get PDFTargeted radionuclide therapy, known as molecular radiotherapy is a novel therapeutic
module in cancer medicine. β-radiating radionuclides have definite impact on target
cells via interference in cell cycle and particular signalings that can lead to tumor
regression with minimal off-target effects on the surrounding tissues. Radionuclides
play a remarkable role not only in apoptosis induction and cell cycle arrest, but also in
the amelioration of other characteristics of cancer cells. Recently, application of novel
β-radiating radionuclides in cancer therapy has been emerged as a promising therapeutic
modality. Several investigations are ongoing to understand the underlying molecular
mechanisms of β-radiating elements in cancer medicine. Based on the radiation dose,
exposure time and type of the β-radiating element, different results could be achieved
in cancer cells. It has been shown that β-radiating radioisotopes block cancer cell
proliferation by inducing apoptosis and cell cycle arrest. However, physical
characteristics of the β-radiating element (half-life, tissue penetration range, and
maximum energy) and treatment protocol determine whether tumor cells undergo cell
cycle arrest, apoptosis or both and to which extent. In this review, we highlighted novel
therapeutic effects of β-radiating radionuclides on cancer cells, particularly apoptosis
induction and cell cycle arrest
In silico assessment of the inhibitory effect of four flavonoids (Chrysin, naringin, quercetin, kaempferol) on tyrosinase activity using the md simulation approach
Get PDFTyrosinase is a tetrameric enzyme that plays an important role in pigment production. Overproduction of melanin,
which may lead to several skin disorders, is a result of tyrosinase activity. Hence, tyrosinase inhibitors are of key
importance in the treatment of these disorders. In the present study, four flavonoid inhibitors, namely chrysin,
naringin, quercetin, and kaempferol, were evaluated physiochemically, and the inhibitory effects of these compounds on tyrosinase activity were evaluated using the molecular dynamics (MD) simulation method. To create
the best conformation of the enzyme-substrate/inhibitor, the docking process for enzyme-substrate, i.e., enzymechrysin, enzyme-quercetin, enzyme-naringin, and enzyme-kaempferol, was performed. The complexes with the
best binding energies were selected as the models for the MD simulation process. Furthermore, the structural
(RMSD, Rg, RMSF, and Distance) and the thermodynamics properties of the complexes were evaluated. Additionally, the PMF was conducted to calculate the binding free energies. The results showed that chrysin, quercetin
and the substrate were at similar distances to the amino acids of the active site, but naringin and kaempferol were
closer to the active site of the enzyme than the substrate. Moreover, the analysis of the binding energy revealed
that the substrates, chrysin, kaempferol, quercetin, and naringin bound to the enzyme with binding energies of
!7.8, !3.1, !7.1, !3.9, and !8.4 kcal/mol, respectively, which confirms that naringin has the highest inhibitory
effect on tyrosinase among other inhibitors, which makes it an appropriate candidate as a whitening agent in skin
disorders
