Journal of Agromedicine and Medical Sciences
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The Correlation between Fat Consumption and Atherogenic Index on Type 2 Diabetes Melitus Patients in dr. Soebandi Hospital
Get PDFOne of the risk factor that can be changed in type 2 diabetes melitus is food consumption. Fat is one of the macronutrients that have significant influence in consumption. Unhealthy diet can be a trigger to macrovascular complication that is coronary heart disease (CHD) which started with atherosclerosis. Atherogenic index is a good predictor for CHD. This study aims to determine the correlation between fat consumption with atherogenic index in DMT 2 patients at RSD dr. Soebandi. This is an analitic observational study with cross sectional design, using 74 type 2 diabetes melitus patients from Internal Poly at RSD dr. Soebandi who met inclusion and exclusion criteria. Fat consumption were obtained with 24-hours food recall interview and atherogenic index were obtained from TG and HDL levels in medical record. The average of fat consumption is 34,01% and as much 33 subjects (44,6%) have high risk of CHD (AI>0,21). Spearman correlation test between fat consumption with atherogenic index is p=0,025 which mean there is significant correlation between fat consumption and atherogenic index in type 2 diabetes melitus patients at RSD dr. Soebandi
Keywords: DM Type 2, fat consumption, carbohydrate consumption, atherogenic index  
The Influence Of Using Extract Neem Leaf (Azadirachta indica A.juss) Soap In The Scabies lesions grade II Healing
Get PDFScabies is an infectious skin disease caused by infection with Sarcoptes scabiei mites. Clinical symptoms of itching in the lesions. There are herbal plants, namely the neem plant with the content of mimba leaf extract, giving a very good effect in providing resistance to mites in vitro. Mimba leaf processing can be done to make various products, including soap products. So the researchers wanted to develop the concept and knowledge of the effects of soap made from mimba leaf extract in curing lesions in scabies grade II patients in the female dormitory of Ponpes Pandanaran Ngunut Tulungagung. This study uses the Quasy Experiment design with an experimental design of Non equivalent control group design. The treatment group was divided into two treatment groups, namely the treatment using neem leaf extract soap (Azadirachta indica A. juss) and using antibacterial soap. The sample was determined using purposive sampling according to the inclusion criteria, as many as 70 respondents. The assessment used observation sheets of lesion wounds according to the modified Bates-jensen wound assessment tool. The results of the analysis of 70 respondents obtained the results of independent t-test statistics obtained a significance value of p (value) = 0,000. The use of solid soap mimba leaf extract (Azadirachta indica A. juss) in dealing with scabies with Azadirachtinya content which is able to provide resistance to mites by inhibiting the life cycle (metamorphosis).
Keywords: Scabies, neem leaves, lesions, healin
The Correlation of Risk Factors to the incidence of Pediculosis capitis on Students in Pondok Pesantren Miftahul Ulum, Jember
Get PDFABSTRACT
Pediculosis capitis is a scalp disease caused by obligate ectoparasite (mite or lice) infection of Pediculus humanus var. capitis. This disease is a contagious disease that influenced by environment and behavior, so it becomes a dominant public health problem in densely populated environment like in boarding school. Some risk factors that cause Pediculosis capitis are; sex, educational level, hair wash frequency, use of comb or hair accessories together, use of bedding or bed together, hair length, and hair type. This study aims to determine the most dominant incidence, analyze the risk factors, and know the biggest risk factors to the incidence of Pediculosis capitis in santri at Pondok Pesantren Miftahul Ulum, Jember. The type of research that used was observational analytics with case control design conducted on 287 samples of SMP and SMA Miftahul Ulum students who fulfilled the inclusion and exclusion criterias. From this research, the proportion of Pediculosis capitis incidence was 214 respondents (74,6%), and then analyzed by Chi-Square test, it was found that the variables had significant relationship (p <0,05) to Pediculosis capitis occurrence, among others; sex, hair wash frequency, use of comb or hair accessories together, use of bedding or bed together, hair length and hair type. The result of logistic regression test shows that sex was the most biggest variable (p value = 0,000).
Keywords: Pediculosis capitis, risk factors, boarding school 
The Correlation between Ferritin Levels and Glutation (GSH) Levels in Major Beta Thalassemia Patient at dr. Soebandi Jember Hospital
Get PDFRepeated blood transfusions in patient with Major Beta Thalassemia leads to iron overload marks by the increased of serum ferritin levels. Free iron caused the change of H2O2 to oxidants by fenton reaction and caused oxidative stress. These oxidants will be counteracted by GSH as antioxidants. The purpose of this study was to investigate the correlation between ferritin levels with GSH in patients with major beta thalassemia in RSD dr. Soebandi hospital Jember. The samples of this study are fifteen (15) patients age 1-18 years who were regularly transfused. Serum ferritin levels were measured by Enzyme-Linked Fluorescent Immuno Assay (ELFA) and plasma GSH levels were measured by Ellman method. Data was analyzed using Pearson correlation test. Serum feritin levels were increased in Major Beta Thalassemia children with average of 3540,46 ± 3925,37 ng/mL. The mean of GSH is 10,46 ± 2,58 µmol. We found significant and negative correlation between serum ferritin and GSH with p value=0,000 and r=-0,951 in Major beta thalassemia patient at RSD dr. Soebandi Jember.
Keywords: Thalassemia, Oxidative stress, Feritin, GS
Effect of Antihipertensive Drugs And Banana (Musa Sp.) To Potassium Serum Levels of Hypertensive Wistar Rats Model
Get PDFConsumption of antihypertensive drugs has the potential to cause drug and food interactions. Captopril/lisinopril can increase potassium levels by inhibiting the activity of renin angiotensin aldosterone. If captopril/lisinopril is consumed together with bananas, there is a risk of hyperkalemia because bananas are a high pottasium fruits. The aimed of this study was to determined the effect of captopril/lisinopril given with banana (Musa Sp) on potassium serum levels of Rattus novergicus strain Wistar hypertension model. This research was an experimental study with a randomized post-test control group design.Thirty (30) male wistar strain rats aged 2-3 months, weighing 200-250 grams were divided into 6 groups. The control group (K-) non-hypertensive rats, the control group (K+) hypertension rats+standard diet, the treatment group (P1) hypertension rats + standard diet + captopril 2.25 mg/kgBB, the treatment group (P2) hypertensive rats + standard diet + lisinopril 0.6 mg/kgBB, treatment group (P3) hypertension rats + standard diet + captopril with banana and treatment group (P4) hypertension rats + standard diet + lisinopril with bananas. Measurement of potassium serum levels was carried out using electrolyte analyzer. Furthermore, the data were analyzed by One Way ANOVA test. The results showed that there were no significant differences in potassium serum levels between all groups. In conclusion, both of captopril 2.25 mg/kgBB and lisinopril 0.6 mg/kgBB given together with banana 9g/kgBB for 3 days hasn’t caused drug and food interactions.
Keywords: banana fruits, captopril, lisinopril, potassium seru
The Difference of Plasma Malondialdehyde (MDA) Level in Farmers Using Chemical Pesticides and Farmers Using Organic Pesticides
Get PDFMany farmers still use chemical pesticides. Chemical pesticides inside the body will form free radicals that will bind to unsaturated fatty acids (cell membrane structures) that cause increased levels of malondialdehyde (MDA). Organic pesticides can be used as an alternative to control pests. Organic pesticides leave no residues to plants and the environment. This study aims to determine the difference of plasma malondialdehid (MDA) levels in farmers who use chemical pesticides in Dawuhan Village, Tenggarang Subdistrict, Bondowoso Regency and farmers who use organic pesticides in Lombok Kulon Village, Wonosari Sub-district, Bondowoso District. This was an observational analytic research with cross sectional research design conducted on 30 farmers who use chemical pesticides and 30 farmers who use organic pesticides. Blood sampling was taken from Mediana cubiti vein. Measurements of plasma malondialdehyde (MDA) were performed using the TBARS method. Based on the result of Unpaired T-test, it was found that p < 0.001 which showed significant difference in plasma malondialdehyde (MDA) level in farmers using chemical pesticides and farmers using organic pesticides. The plasma malondialdehyde (MDA) level average were higher in farmers using chemical pesticides.
Keywords: Chemical Pesticide, Organic Pesticide, Plasma Malondialdehyde  
The Correlation between Administration of Alpha Lipoic Acid and Malondialdehyde Level on Traumatic Brain Injury Model Rat’s Brain
Get PDFChronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive brain trauma that cancontinues to be dementia, alzheimer and parkinsonism. Traumatic brain injury increased free radicals in brain thatcaused oxidative stress and induced lipid peroxidation, neuron damage and producing MDA. The purpose is todetermine the correlation between administration of ALA and MDA level in rat’s brain model of traumatic braininjury and its effective dose. Rats are randomLy divided into 7 groups. Normal group without treatment, K(-) wasgiven NaCl 0,9% 1,5 mL, K(+) was given citicoline 6,75 mg, K1 was given ALA 1,0125 mg, K2 was given ALA 2,025mg, K3 was given ALA 4,05 mg, K4 was given ALA 8,1 mg and received 30 days traumatic brain injury treatment bydropped 245 g load on the rat’s head at 35 cm height. MDA level in brain were measured on the 31th day withMDA-TBA method by spectrofotometer. The averages of MDA levels were N 1,64 μg/mL; K(+) 2,09 μg/mL; K(-) 4,87μg/mL; K1 2,73 μg/mL; K2 2,68 μg/mL; K3 2,20 μg/mL and K4 2,02 μg/mL. Pearson’s analysis shows strong andsignificant negative correlation (r= -0,790) between administration of ALA and MDA level in rat’s brain model oftraumatic brain injury (p<0,05). The effective dose of ALA is 8,625 mg/150gBW.Keywords : Alpha lipoic acid, MDA, traumatic brain injury, CT
The Analgesic Effectiveness Test of Cocoa Husk (Theobroma cacao L.) Extract to Licking Time of Mice Induced by Formalin
Get PDFCocoa (Theobroma cacao L) is an industrial material that often used in chocolates production, but the part that used is cocoa bean, so that cocoa husk accumulate as waste. This study aimed to determine effectiveness of cocoa husk extracts to first and second phase of licking time of mice induced formalin. This study used 28 mices that divided into seven groups. NaCMC 1% to group K(-), 0.0048 mg/gBW sodium diclofenac to K(+), extracts dose variations, ie 0.25 mg/gBW, 0.5 mg/gBW, 1 mg/gBW, 2mg/gBW and 4 mg/gBW to group K1, K2, K3, K4, and K5 administered orally 30 minutes before subcutaneous injection of 200 μl formaldehyde 2.5% on hind paw. Graph of dose response on first phase data was fluctuate with highest inhibition percentage occurred on dose group 0,5 mg/gBW and 1 mg/gBW, that is 68,750% while on second phase data was biphasic with highest inhibition percentage occurred on dose group 1mg/gBW, that is 94,052%. One Way ANOVA analysis showed no significant difference (p> 0.05) on first phase, but showed significant difference (p <0,05) on second phase. This results indicated that cocoa husk extracts can decrease second phase, inflammatory phase significantly.
Keywords: cocoa, analgesic, licking time, formaldehyde, inflammatory phas
Histopathological Changes in the Wistar Rats Liver Treated with Bangle (Zingiber cassumunar Roxb.) Rhizome Ethanol Extract during Acute Toxicity Test
Get PDFMalaria is still an infectious disease that can not be eradicated. The presence of antimalarial drug resistance case encourages the research on herbal plants that are expected to be a complementary therapy drug of malaria, one of them is bangle (Zingiber cassumunar Roxb.). This research aimed to investigate the effect of bangle (Zingiber cassumunar Roxb.) rhizome ethanol extract to the histopathological changes of Wistar rats liver during acute toxicity test. This research type was true experimental laboratories with posttest only control group design using four treatment groups (given dose 42,609 mg/200gBW + Tween 1%, 213,045 mg/200gBW + Tween 1%, 426,09 mg/200gBW + Tween 1%, and 852.18 mg/200gBW + Tween 1%) and one control group (given 1% Tween). Each treatment groups consisted of five male rats and five female rats. The final mean score of hepatocyte damage as the research data was analyzed by One-Way ANOVA test and showed that p=0,084. It indicated that there was no significant difference of liver histopathology results between groups.
Keywords: malaria, bangle rhizome, acute toxicity test, liver histopatholog
Effect of Soyflour (Glycine max L.) Hepatoprotector Activity on Liver MDA Level in Male Wistar Rat Induced by Diazinon
Get PDFDiazinon is metabolized in liver becomes diazoxon, an active metabolite form that can cause free radical raisingthat leads to lipid peroxidation. The result of lipid peroxidation is MDA. Soyflour has higher isoflavones than theother processed food of Glycine max L.This isoflavones donate its electron and hydrogen atom in lipidperoxidation so it can block the lipid peroxidation. The aim of this experiment is to investigate the effect of soyflour on MDA hepar level increase of male wistar rat induced by diazinon. The sample are divided into 5 groupswhich are Kn, K(-) group induced by diazinon 40mg/kgBW, K1, K2, K3 group given with soy flour 10%, 15%, and20% orally, then induced by diazinon 40 mg/kgBW. MDA liver measured on the day 34th with MDA-TBAmethode which has pink colour and measured by spectrofotometer. Average of liver MDA levels is Kn 6,35μg/mL; K(-) 9,23 μg/mL; K1 8,85 μg/mL; K2 7,88 μg/mL; K3 7,04 μg/mL. One way ANOVA and Post hoc LSDshowed significantly different (p<0,05). Pearson correlation showed strong negative correlation.
Keywords: Diazinon, Diazoxon, MDA, Soyflour, Glycine max L., antioxidan