Journal of Agromedicine and Medical Sciences
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Relationship of Cholinesterase Activity with Blood Glucose Levels Due to Pesticide Exposure to Farmers in Mlokorejo Village
Full text linkIncrease in blood glucose levels can be caused by the long-term use of pesticides by farmers. This study aims to determine whether there is a correlation between the activity of cholinesterase as an indicator of exposure to pesticides and blood glucose of farmers in Mlokorejo Village, Jember Regency. The research method is observational-analytic with a cross-sectional study design. Data in the form of general characteristics of the sample were obtained through interviews, while the data of the activity of cholinesterase and blood glucose levels of farmers were obtained at the Biochemical Laboratory of the Faculty of Medicine, Jember University. The sample size of this study is 30 samples. All of the samples are having an increased activity of cholinesterase. Most of the samples are having normal blood glucose levels. Based on the results of statistical analysis using the Spearman correlation test (a= 0.05), it was concluded that there was no significant correlation between the two variables (p = 0,191).
Keywords: blood glucose, cholinesterase, pesticide
The Effect of Azadirachta indica leaves extract on Transforming Growth Factor-β and Tumor Necrosis Factor-α in a Plasmodium berghei infected Mice model
Full text linkMalaria is a health problem for the world's population and is predominantly located in tropical and subtropical areas. The three countries with the most malaria cases are India (58%), followed by Indonesia (20%), then Myanmar (16%). This study aims to determine the effect of neem leaf extract on increasing TGF-β expression and decreasing TNF-α expression in mice infected with Plasmodium berghei. In this study there were four groups, namely Treatment 1 (in Plasmodium berghei infection without therapy). Treatment 2 (in Plasmodium berghei infection and treated with Azadirachta indica leaf extract at a dose of 0.25 mg / g BW). Treatment 3 = (in Plasmodium berghei infection and therapy with Azadirachta indica leaves at a dose of 0.5 mg / g BW). Treatment 4 = (in Plasmodium berghei infection and treated with Azadirachta indica leaves at a dose of 1 mg / g BW). TGF-β examination by elisa method and TNF-α by immunohistochemistry. Data analysis using SEM (Structural Equation Modeling) The results of treatment 1 and 2 showed a decrease in plasma TGF-β expression (t = 1.13; tcount = 1.93; ≥ttabel = 1.96) and spleen (tcount = 1.53; tcount = 1.45; ≥ttabel = 1.96) but there was an increase in spleen TNF-α expression (tcount = 1.77; tcount = 1.00; ≥ttabel = 1.96). Groups 3 and 4 showed an increase in plasma TGF-β expression (tcount = 5.13; tcount = 2.42; ≥ttable = 1.96) and spleen (tcount = 2.00; tcount = 1.97; ≥ttabel = 1.96) but there was a decrease in spleen TNF-α expression (tcount = 2.03; tcount = 2.11; ≥ttabel = 1.96). Conclusion: Azadirachta indica leaf therapy can increase TGF-β expression and decrease TNF-α expression in the spleen.
Keywords: Azadirachta indica ethanol extract, transforming growth factor- β, tumor necrosis factor-Î
The Protection Effect Of Methanol Extract From Asam Jawa Seed On Testicular Tissue Damage Induced By Aluminium Chloride (AlCL3)
Full text linkAluminum is known has neurotoxin effect that can lead to alzheimer's disease, dementia, and parkinson's. Metal ions such as aluminum can distract homeostasis and increase oxidative stress level, formation of reactive oxygen species (ROS) that can overwhelm antioxidant defenses and cause DNA damage, lipid peroxidase, leading to the destruction of testicular cells. Tamarindus indica’s seeds are one of the traditional plant and useful as antioxidants. Tamarindus indica’s seeds are able to protect testicular cells from damage caused by ROS. The purpose of this study to determine the effect of methanol extract from Tamarindus indica’s seeds to prevent aluminum chloride induced testicular damage to be measured from the histopathological features. This study is a quasi experimental design with a posttest design only with non-equivalent groups using thirty male Wistar rats divided into five groups, one control group and four treatment groups. The control group was given 1 mL of aquabides solution orally. Group P1 was given a dose of aluminum solution 300 mg/kgBW orally. Groups P2, P3, and P4 were each given an aluminum solution at dose of 300 mg/kgBW orally and an extract solution at a dose of 25, 50, 100 mg/kgBW orally for 10 weeks. The results of the observations showed that the scores varied between groups. Data analysis using Kruskal-Wallis test obtained p value = 0.006 (p <0.05). Post Hoc test using Mann Whitney obtained varied p values. Post Hoc analysis between K and P1 groups, P1 and P3 groups, P1 and P4 groups showed a significant difference with p value <0.05. Based on the results of this study, methanol extract from tamarind seeds (Tamarindus indica) that was given to male wistar rats had prevented histopathological damage to the testes of rats induced by aluminum chloride (AlCl3).
Keywords: aluminium, testicular cell, Tamarindus indic
The Relationship between Knowledge with Doctors and Nurses’ Compliance Level to Use PPE in Hospital Surgery Room during Pandemic Era
Full text linkHospitals are not only as a place of treatment, but also as a health service facility that can be a source of infection for other people. Doctors, nurses and other medical personnel are often exposed to potential hazards in hospitals, thus requiring protection in the form of personal protective equipment (PPE). However, compliance with the use of PPE is not always high, which makes doctors and nurses more vulnerable to risk of occupational diseases in hospitals. In one of conducted studies, the conditions that were less compliant in using PPE for health workers were 30%. One of the things that might affect this level of compliance is knowledge about PPE. The purpose of this study was to determine the relationship between knowledge and compliance level to use personal protective equipment among doctors and nurses in operating room installation from a private hospital in 2020. Analytic observational by using cross sectional research design was used in this study. The population were all doctors and nurses at operating room installation of mentioned hospital above. Sampling was taken by total sampling method and 26 samples met the inclusion criteria. In this study, there were 23 respondents (88.5%) obeyed the use of personal protective equipment, meanwhile 3 respondents (11.5%) who did not. The 3 respondents were on loop or circular nurses. So, there was a significant relationship between the level of knowledge and compliance in the use of personal protective equipment with p-value = 0.027and OR=44.
Keywords: personal protective equipment, knowledge level, compliance leve
The Effectiveness of Acupuncture Therapy in Patient with Hemorrhoid: A Case Report
Full text linkBackground: Hemorrhoid is an anorectal disease due to mechanical disturbances in the anal cushion and hemorrhoid venous plexus blood flow obstruction. Symptoms that often accur are bleeding, pain, prolapse, itching, and mucus discharge. Acupuncture is non-pharmacological therapeutic modalities that has been shown to improve hemorrhoid symptoms.
Case: A 37-year-old woman complained of hemorroid lump with pain since last 1 year. Physical examination showed a reddish hemorrhoid prolapse, about 1.5 cm in the posterior anal without bleeding. The pain score with NRS is 4. Acupuncture therapy was performed 3 times a week at acupoints GV20, TE6, LU6, ST25, BL34, ST36, EX-UE2 and BL57. Then given continuous wave electrical stimulation, 4 Hz, 30 minutes retention. After 11 treatments, pain disappeared with NRS 0 and lump was reduced to about 0.5 cm.
Conclusion: Acupuncture can improve the symptoms of hemorrhoids, which are seen by the relief of pain and the reduction of lumps.
Keywords: Acupuncture, hemorrhoid, hemorrhoid pain, hemorrhoid prolaps
Correlation of Platelet Count and Hematocrit Levels to the Severity of Dengue Hemmoraghic Fever Patients at RSD dr. Soebandi Jember
Full text linkDengue hemorraghic fever (DHF) is an infectious disease caused by the dengue virus and It is still be a major health problem in Southeast Asia, especially in Indonesia. Kabupaten Jember is still categorized as a dengue endemic area with its disease development expanding from year to year. This study aims to determine the correlation of platelet count and hematocrit levels to the severity of DHF patients at RSD dr. Soebandi Jember, as well as knowing whether the platelet count and hematocrit levels can be used as a predictive value for the severity of DHF patients at RSD dr. Soebandi Jember. This study used an observational analytic study with a cross-sectional study design. The data of this study used secondary data from the medical records of DHF patients at RSD dr. Soebandi Jember. The results of this study with a total of 68 samples showed that there was a significant negative correlation between the platelet count to the severity of DHF patients (p = 0,000, r = -0,487). The hematocrit levels showed an insignificant and negative correlation to the severity of DHF patients (p = 0,658, r = -0,055). The platelet count can be used as a predictive value for the severity of DHF patients.
Keywords: DHF, platelet count, hematocrit levels, severity of DHF patients
 
Efficacy and Safety of Transcatheter Ventricular Septal Defect Closure Using Nit-Occlud Le VSD coil in Short-term Observation
Full text linkNit-Occlud Le VSD coil, an alternative device for closing VSD transcatheter, started to be used in dr. Soetomo Hosptal in 2017, but no research has been done on the results of closure with this device. This study aims to evaluate the efficacy and safety of the Nit-Occlud Le VSD coil. Descriptive observational method was used. The results are as follow: Of the 17 patients who underwent transcatheter closure during January to December 2018, 10 (58, 8%) cases were closed with Nit- Occlud Le VSD coil. The success of implantation is 100%, 8 cases were closed with Nit-Occlud Le VSD coil, 2 plus an amplatzer (ADO 1 and AVSO). Type of VSD: perimembranaous 7 (70%), subaortic 2 (20%) and mid muscularis 1 (10%). Immediate complete closure in 7/10 (70%), while 3 (30%) obtained residual DSV. The closure rate at the first month of follow up becomes 80%. Median length of post-catheterization was 2 days (2 - 3 days). Complications: 1 (10%) mild aortic regurgitation, 1 (10%) hemolysis and 2 (20%) with additional second device (ADO 1 and AVSO): first case: moderate residual VSD and severe aortic regurgitation; second case: severe tricuspid regurgitation and residual VSD that disappeared in first month. The residual VSD altered from 30% to 10%, and closure rate was 80% at the first month of observation. VSD closure with Nit-Occlud Le VSD coil provides good efficacy and safety for patients.
Keywords: VSD, Nit-Occlud Le VSD coil
The Use of Saturated MgSO4 Compared to Saturated Sucrose in the Flotation Method to Identify Eggs and Larvae of Soil-Transmitted Helminths from Plantation Soil
Full text linkWorms infection is still common in Indonesia with a prevalence that varies around 40% -60% at all ages. This disease can be caused by infection of Soil-Transmitted Helminths (STH) that require soil media to infect humans. The many plantation lands in Jember are a suitable environment for the development of STH and STH identification in soil can be done by flotation method using MgSO4 solution or sucrose. The comparison of the effectiveness of the MgSO4 solution with the sucrose solution has not been widely studied. Therefore, the aim of this study was to compare the efficacy of using saturated MgSO4 solution with saturated sucrose to identify eggs and larvae of STH in Sumber Wadung plantation soil, Hargomulyo Village, Silo District, Jember Regency using the flotation method. Soil samples were taken as many as 35 samples in the garden area, 35 samples around the river, and 35 samples in residential areas,. The results of identification of STH eggs and larvae obtained Ascarid eggs (1.9%) and Hookworm larvae (0.01%). The number of positive soil samples containing STH eggs and larvae using different solutions is the same as three samples (0.02%).The Wilcoxon test results showed that there was no difference in the results of using the MgSO4 solution with the sucrose solution in the flotation method (p> 0.05) so that the MgSO4 solution and sucrose solution could be used to detect eggs and larvae of STH worms and had the same effectiveness.
Keyword: Soil-transmitted helminths, saturated MgSO4, saturated sucrose, flotatio
Manual Acupuncture Effect on Vertigo and Tinnitus in Patient with Labyrinthitis: A Case Report
Full text linkLabyrinthitis is an inflammatory disease of the inner ear perilymphatic cavity and the most common cause of prolonged spontaneous vertigo. Other symptoms are tinnitus and sensorineural hearing loss. Acupuncture is one of the non-pharmacological therapeutic modalities to improve symptoms of labyrinthitis. A 54-year-old woman complained of vertigo that is preceded by tinnitus in both ears since the last 6 months. She was diagnosed with labyrinthitis. Had taken amoxicillin and decadryl for 5 days, betaserc and dimenhydrinate when she felt dizzy, and amlodipine as a routine drug for her hypertension. Physical examination showed vital signs within normal limits, grade 2 obesity, positive Romberg test, and THI score 18. Manual acupuncture was performed at acupoints GV20, GB20, TE17, TE21, SI19, GB2, GB8, TE5, LI4, KI3, PC6 and LR3 with 20 minutes retention. After the first therapy, vertigo complaints disappeared and after 12 treatments (twice a week), frequency and intensity of tinnitus became less, with THI score of 6. Therefore, acupuncture can relieve vertigo and improve tinnitus which can be seen by a decrease of THI score.
Keywords: acupuncture, labyrinthitis, tinnitus, vertig
Prevalence of Stunting According to WHO Growth Standards and Indonesian Growth Reference Charts: A Descriptive Study from Blega Sub-District
Full text linkStunting is one of the remaining health issues in Indonesia and its prevalence was still high in the last decades. There are two types of growth charts that can be used in recording the child's growth: growth standards and growth references. In recent times, the selection of the suitable growth charts has become a subject of discussion in many countries. The objective of this study is to describe the prevalence of stunting according to World Health Organization Child Growth Standards (WHOCGS) and Indonesian National Growth Reference Charts (INGRC) of children under five from the Blega sub-district. The secondary data from 2884 children were collected recapitulation of the 'Bulan Timbang' program in February 2020. Z-score of length/height-for-age was plotted according to WHOCGS and INGRC. The result showed that the prevalence of stunting were lower for the INGRC than WHOCGS (5.83% and 11.17%, with p-value <0.001). There was an advantage and disadvantage when using both two growth charts. Further research is still needed to support the result of this study.
Keywords: Stunting, World Health Organization Child Growth Standards, Indonesian National Growth Reference Chart