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On a family of contrasts for parametric inference in degenerate arch models
No full textInternational audienc
Deep convective clouds and convective overshootings characterization during HyMeX SOP1: a multi-instrument approach
No full textInternational audienc
Cartographier la concentration intracellulaire d’espèces oxygénées réactives
No full textInternational audienceL’organisation dans le temps et l’espace des voies de signalisation est un élément essentiel dans le façonnage de la réponse cellulaire. Ceci est vrai notamment dans les processus chimiotactiques, où l’apparition d’une organisation intracellulaire asymétrique est physiologiquement indispensable. Dans ce contexte, la signalisation par les espèces oxygénées réactives, ou ROS, est singulière. En effet, ces molécules, comme le peroxyde d’hydrogène H2O2, sont connues principalement pour leur activité bactéricide et les dommages induits par le stress oxydant. Elles jouent cependant en parallèle un rôle essentiel dans plusieurs voies de signalisation physiologiques contrôlant des réponses variées – contraction, prolifération, migration – dans de nombreux tissus (systèmes nerveux, hépatique, vasculaire, etc.). L’homéostasie locale des ROS est donc un processus vital dans la vie cellulaire pour préserver l’action physiologique sans effet nuisible
Hausdorff measures and dimensions in non equiregular sub-Riemannian manifolds
No full textInternational audienc
Dynamique de formation des biofilms de Bacillus subtilis à l’interface eau-air : expériences et modélisation
No full textMost of the time, the bacteria live inside the biofilm: the biological tissue that is attached to the surface (soft or solid), is made of the bacteria and of extracellular matrix. According to this thesis we study the mechanics that control the formation of a biofilm at the interface water-air by Bacillus subtilis (BS). First, we absorbed the phenotype evolution of the BS during the development of its population in liquid medium, under the conditions of a standard culture (no of biofilm in fine). We noticed that the population exhibits different cellular types (phenotypes) during this time. Then, after absorbing the different stages of the development in the formation of a biofilm, we created an experience that allows us to follow the macroscopic evolution of the concentration of the bacteria and its special distribution in the middle of the culture. We found that an accumulation of the bacteria forms under the surface water-air, even before the appearance of a biofilm. This accumulation is concomitant with the conservation in the liquid (bioconvection). The biofilm appears during the growth phase of the bacterial population in an average concentration in the culture medium of about 10¹³ bacteria / m³. Then, we formed a continuous model that shows us the evolution of the environment of the bacteria. This model reproduced the bioconvection that was observed in the experiments and reveals its effect on the concentration of oxygen in the biological culture. Finally we built a hybrid continuous-discreet model that described the transition of the disconnected bacteria (nomads) through the connected bacteria that form a solid biofilm (sedentary). Each bacteria is considered as an individual particle. The model takes the contact forces under consideration, as well as the elastic forces that can settle between the bacteria when linked by the matrix. A minimum number of biological skills were used to form a model from the bacteria; the cellular division that allowed it to colonize the medium biological culture, the motility and the aerotaxi that explains its migration towards the liquid surface, the quorum sensing (QS) and the cellular differentiation that allows them to spend nomadic phenotype (motile) sedentary phenotype (producer of matrix). The dioxygen environment of the bacteria and its middle hydrodynamic properties are described by continuous fields. The model reproduces all the formation steps of an observed biofilm in our experiment and confirms the need of certain biological skills. It shows that the threshold of QS plays a major role in the morphology and biofilm formation kinetics. On the other hand, the rate of diocygen consumption by the bacteria does not seem to have any significant role. Finally, we established that the bioconvection reacts as a retardant in the biofilm formation.La plupart du temps, les bactéries vivent au sein de biofilms : un tissu biologique accroché sur des surfaces (molles ou solides), qui est composé de bactéries et de matrice extracellulaire. Lors de cette thèse nous avons étudié les mécanismes qui contrôlent la formation d’un biofilm à l’interface eau-air par Bacillus subtilis (BS). D’abord, nous avons observé l’évolution phénotypique de BS au cours du développement de sa population en milieu liquide, dans des conditions de culture standard (pas de biofilm in fine). Nous avons constaté que la population exhibe différents types cellulaires (phénotypes) au cours du temps. Puis, afin d’observer les étapes de la formation d’un biofilm, nous avons créé une expérience qui permet de suivre l’évolution macroscopique de la concentration des bactéries et sa répartition spatiale au sein du milieu de culture. Nous constatons qu’une accumulation de bactéries se forme en dessous de l’interface eau-air avant même l’apparition d’un biofilms. Cette accumulation est concomitante avec de la convection dans le fluide (bioconvection). Le biofilm apparait lors de la phase de croissance de la population en bactérie pour une concentration moyenne dans le milieu de culture de l’ordre de 10¹³ bactéries/m³. Ensuite, nous avons formulé un modèle continu qui renseigne sur l’évolution de l’environnement des bactéries. Ce modèle reproduit la bioconvection observée dans les expériences et révèle son effet sur la concentration en dioxygène dissous dans la culture. Enfin, nous avons construit un modèle hybride continu-discret qui décrit la transition de bactéries déconnectées (nomades) vers des bactéries connectées formant un biofilm solide (sédentaires). Chaque bactérie est considérée comme une particule individuelle. Le modèle tient compte des forces de contact, ainsi que les forces élastiques qui peuvent s’établir entre les bactéries lorsqu’elles sont liées par de la matrice. Un nombre minimal d’aptitudes biologiques a été utilisé pour modéliser les bactéries : la division cellulaire qui leur permet de coloniser le milieu de culture, la motilité et l’aérotactisme qui explique leur migration vers la surface liquide, le quorum sensing (QS) et la différenciation cellulaire qui leur permet de passer du phénotype nomade (motile) au phénotype sédentaire (producteur de matrice). L’environnement en dioxygène des bactéries et les propriétés hydrodynamiques du milieu sont décrits par des champs continus. Le modèle reproduit toutes les étapes de la formation d'un biofilm observées dans nos expériences et confirme la nécessité de certaines aptitudes biologiques. Il montre que le seuil de QS joue un rôle majeur dans la morphologie du biofilm et sa cinétique de formation. En revanche, le taux de consommation de dioxygène par les bactéries ne semble pas avoir de rôle important. Enfin, nous avons établi que la bioconvection agit comme un retardateur de la formation du biofilm
Courbure des systèmes de contrôle optimal et applications en géométrie sous-Riemannienne
No full textOptimal control theory is an extension of the calculus of variations, and deals with the optimal behaviour of a system under a very general class of constraints. This field has been pioneered by the group of mathematicians led by Lev Pontryagin in the second half of the 50s and nowadays has countless applications to the real worlds (robotics, trains, aerospace, models for human behaviour, human vision, image reconstruction, quantum control, motion of self-propulsed micro-organism). In this thesis we introduce a novel definition of curvature for an optimal control problem. In particular it works for any sub-Riemannian and sub-Finsler structure. Related problems, such as comparison theorems for sub-Riemannian manifolds, LQ optimal control problem and Popp's volume and are also investigated.Optimal control theory is an extension of the calculus of variations, and deals with the optimal behaviour of a system under a very general class of constraints. This field has been pioneered by the group of mathematicians led by Lev Pontryagin in the second half of the 50s and nowadays has countless applications to the real worlds (robotics, trains, aerospace, models for human behaviour, human vision, image reconstruction, quantum control, motion of self-propulsed micro-organism). In this thesis we introduce a novel definition of curvature for an optimal control problem. In particular it works for any sub-Riemannian and sub-Finsler structure. Related problems, such as comparison theorems for sub-Riemannian manifolds, LQ optimal control problem and Popp's volume and are also investigated
Tunable luminescence from Ce-doped aluminoborosilicate glasses
No full textInternational audienceA series of aluminoborosilicate glasses were prepared using the melt-quenching technique for mixture of stoichiometric amounts of SiO 2 , Al 2 O 3 , H 3 BO 3 , Na 2 CO 3 , and ZrO 2 with adding of different amounts of CeO 2. The samples were investigated by means of luminescence spectroscopy. Tunable luminescence from violet to blue/green was observed from these glasses with different Xe-lamp excitation wavelengths ranging from 370 to 480 nm as well as with laser excitation of 266 and 355 nm. Moreover it was found that the possibility of tuning the light by changing of excitation wavelength was not unique. The same effect was observed by adjusting conditions for luminescence measurements as well as under exposure to β-irradiation. The obtained phenomena could be explained taking into account structural characteristics of this glass and it could be concluded that tunable luminescence results from the presence of different Ce-sites the glass matrix. Thus the results suggest that Ce-doped glasses could be considered as conversion materials for blue light-emitting diode chips to generate white light-emitting diodes. Ce 3+ ions were widely used as activators in various fluoride and oxide materials. The preparation of RE-doped phosphor materials for application in advanced illumination technologies has been the subject of intense research during recent decades. These researches are stimulated by the necessity of increasing the efficiency in white light emitting solid state devices which represent an alternate lightning source [1
