ACI (Acta Cardiologia Indonesiana)
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Critical Appraisal of Macitentan in Pulmonary Arterial Hypertension
No full textCritical Appraisal of Macitentan in Pulmonary Arterial Hypertensio
High Apo B/Apo A-1 Serum Ratio As a Predictor of in-Hospital Major Adverse Cardiovascular Events in Acute Coronary Syndrome Patients
No full textBackground: An increased level of apo B and decreased level of apo A-1 are thought to be better predictors of myocardial infarction than conventional lipid parameters in healthy individuals and/ or have coronary artery disease risk factors. Literatures said that HDL, LDL and apolipoprotein may have a role in haemostatic and thrombotic process. The present study aimed to investigate whether apo B/ apo A-1 ratio has a predictive role in hospitalised ACS patients to develop major adverse cardiac events (MACE). Methods: We performed a prospective cohort study and examined 182 ACS patients hospitalised in dr. Sardjito General Hospital Yogyakarta consecutively since September 2013, and evaluated ischaemia heart disease risk factors, measured concentration of apo B/apo A-1 ratio and conventional lipid parameters from plasma, and finally assessed the in-hospital MACE outcome. Apo B/Apo A-1 ratio cut off point in this study was taken from ROC curve analysis. Relation between in-hospital MACE with level of apo B/apo A-1 ratio was analysed using SPSS. Results: From 182 ACS subjects, 51 patients had MACE (MACE group) and 131 patients didn’t develop MACE (non-MACE group). From ROC curve, we set cut off point for apo B/apo A-1 ratio was 0,865. Subjects with an apo B/apo A-1 ratio ≥0,865 had a signifi cantly increased risk to suffer a cardiovascular event (MACE) during in-hospital follow-up. In a multiple logistic regression model, elevated apo B/apo A-1 ratio was an independent predictor for MACE during in-hospital follow-up (OR 3,17; 95%CI 1,299 - 7,738; p = 0,011). Conclusion: The results showed that the elevated apo B/apo A-1 ratio ≥0,865 was an independent predictor of MACE, with three-folds increase of risk compared to group of apo B/apo A-1 ratio < 0.865, during in-hospital follow-up in ACS patients.Keywords: apolipoprotein B; apolipoprotein A-1; apolipoprotein ratio; acute coronary syndrome; major adverse cardiovascular event
Correlation Between Right Ventricular Function Using Myocardial Performance Index (Tei Index) with Pulmonary Arterial Hypertension Severity in Patient with Atrial Septal Defect
No full textBackground: Right ventricular (RV) volume overload that occurs in patients with atrial septal defect (ASD) could lead to the development of pulmonary arterial hypertension (PAH). RV function has been found depressed in some patients with PAH. Myocardial performance index (MPI) is one of methods to assess RV function. The aim of this study was to assess correlation between RVfunction using RV-MPI with PAH severity in patients with ASD. Methods: We conducted a cross sectional study between July 2012-July 2013. We enrolled 67patients with secundum type ASD. RV-MPI, defi ned as the sum of isovolumic relaxation time and isovolumic contraction time derived by ejection time, was measured from tricuspid infl ow and RV outflow. The normal range is 0.28-0.32. Pulmonary artery systolic pressure (PASP) was measured from echocardiography. Results: There were 67 patients (54 women) with mean age was 38.01±14.29 years (11.9% with no PAH, 11.9% mild PAH, 26.9% moderate PAH and 49.3% severe PAH). The mean PASP was 67.16±32.33 mmHg and mean MPI was 0.44±0.25. We found signifi cant correlation between PASP and MPI (r=0.73; p=0.000). In addition, we classifi ed the PAH severity based on PASP and there was signifi cant differences of MPI between groups (no PAH, MPI 0.25±0.07; mild PAH 0.24±0.05; moderate PAH 0.24±0.12; severe PAH 0.63±0.21; p=0.000). Furthermore, in severe PAH group, the correlation between PASP and MPI remain signifi cant (r=0.42; p<0.05). Conclusion: These result demonstrate a correlation between PAH severity and MPI in patientswith ASD. Specifi cally, RV function found decreased in ASD patients with severe PAH.Keyword: myocardial performance index (Tei index), pulmonary arterial hypertension, right ventricular function, atrial septal defec
Diagnostic Value of Addition First One Minute Abnormal Heart Rate Recovery After Exercise Treadmill Test in Moderate Risk Duke Treadmill Score to Detect Severe Coronary Artery Lesion in Patient Suspected Stable Coronary Artery Disease
No full textBackground: Duke Treadmill Score (DTS) and first one minute abnormal heart rate recovery ......
Impact of Second-Hand Smoke Exposure with Hypertension Status Among Housewives Aged 40-55 Years at Rural Areas
No full textIntroduction. As the leading environmental risk factor for cardiovascular diseases, national ....
The Relationship of Body Mass Index (BMI) with The Result of A Six-Minute Walk Test Elderly Pilgrims at Saiful Anwar General Hospital Malang
No full textBackground: In the last 2 decades the mortality rate of Indonesian pilgrims is 200-380 deaths per ....
Association between Metabolic Syndrome and Six Minutes Walk Distance on Elderly Pilgrims
No full textBackground: SISKOHATKES data on 2017 mentioned that the number of morbidity and ....
Pathogenesis and Drug Development for Pulmonary Arterial Hypertension
No full textPathogenesis and Drug Development for Pulmonary Arterial Hypertensio
Pulmonary Hypertension in Adult Congenital Heart Disease: From Registry to Policy
No full textPulmonary Hypertension in Adult Congenital Heart Disease: From Registry to Polic