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    Sub-acute toxicological assessment of n-hexane fraction of Anogeissus leiocarpus stem bark extract in rats.

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    Anogeissus leiocarpus is traditionally used in Africa for treating diabetes and gastrointestinal disorders; and pharmacologically validated for its anti-inflammatory and antioxidant properties. However, data on the toxicological profile of its fractions remain limited. This study evaluated the acute toxicity of A. leiocarpus stem bark hydromethanolic extract (ALBHE) and subacute toxicity of its n-hexane fraction (n-hex). Acute toxicity was assessed by administering single oral doses of ALBHE (2000 and 5000 mg/kg body weight) to female rats (n = 5/group) and monitored for 14 days. For the subacute study, male and female rats (n = 10/group) received repeated oral doses of n-hex (40 or 80 mg/kg) for 28 days. The animals were sacrificed on day 29 following overnight fasting, and blood and essential organs (liver, kidney, heart, spleen, brain, uterus, and testes) were collected for haematological, biochemical, and histological assessments. Chemical profiling of nhex was performed using high-performance liquid chromatography (HPLC), revealing 12 distinct compounds. No mortality or clinical signs of toxicity were observed in the course of acute toxicity. Haematological and biochemical parameters were not significantly altered (p > 0.05) compared to controls except for the mean corpuscular volume which was significantly decreased (p < 0.05) in male rats compared to control, and histological examination revealed well-preserved organ architecture. Taken together, the oral median lethal dose (LD50) of ALBHE was greater than 5000 mg/kg and the results indicate that both ALBHE and its n-hexane fraction are non-toxic at the tested doses and duration, supporting their potential safety in therapeutic applications

    Fruit and vegetable intake among Nigerian University students: patterns, preferences, and influencing factors

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    Adequate consumption of fruits and vegetables is globally recognized as a cornerstone of healthy living and a critical strategy for preventing micronutrient deficiencies and non-communicable diseases. Yet, among young adults, particularly university students in low and middle-income countries like Nigeria, dietary habits often fall short of recommended guidelines, raising public health concerns. This research, therefore, examined fruit and vegetable intake among Nigerian university students, specifically exploring patterns, preferences, and influencing factors of fruit and vegetable consumption. Using a stratified random sampling technique, 309 students aged 15–25 years were selected across various colleges in the study area. Data were collected through a structured food frequency questionnaire with a 7-day recall period, alongside anthropometric measurements including weight, height, and Body Mass Index (BMI). Descriptive statistics and an ordered probit model were employed to analyse the data. The findings reveal that the average BMI was 23.11 kg/m2, and the mean age was 19 years. Fruit and vegetable intake among the students was significantly below the World Health Organization’s (WHO) recommended daily intake of 400 g. Key factors influencing consumption included age, sex, monthly allowance, availability, nutritional knowledge, and preference for fast food. The study highlights the need for targeted interventions that go beyond nutritional education and fruit and vegetable availability to holistically address behavioral drivers and facilitate consumer decision-making. A comprehensive approach could involve cooking workshops, price reductions, appealing food presentation, prominent display of fruits and vegetables in university cafeterias and expert dietary guidance to foster long-term healthy eating habits

    REVENTIVE STRATEGIES AND THEIR IMPACT ON PERCEIVED EFFECTS OF CRIMES ON RURAL FAMILY LIVELIHOODS IN OGBOMOSO AGRICULTURAL ZONE OF OYO STATE, NIGERIA

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    he study therefore examined the preventive strategies in tackling the perceived effects of crimes in rural family livelihoods in Ogbomoso Agricultural zone of Oyo State. Multistage sampling procedure was employed to select 90 rural families for this study. Data was obtained with the aid of a questionnaire and data were analysed using frequency count, percentage, mean and Pearson Product Moment Correlation. The results showed that the major effects of crime on rural family livelihoods were loss of stored products (4.82), loss of resources (4.37), and loss of yield of crops (4.91). While major preventive strategies against crime were keeping farm area clean always (3.00), setting of traps around barns/stores (2.96) and the use of vigilante group for surveillance (2.92). Pearson’s Products Moment Correlation (PPMC) analysis indicated that the perceived effects of crimes on rural family livelihoods were negative and significantly related to the frequency of preventive strategies against crimes (r=- 0.221**; p= 0.037). The result showed that preventive strategies against various crimes/criminality were found to be inversely and significantly related to the perceived effects of crime/criminality on rural family livelihoods. It was therefore concluded that the preventive strategies against crime/criminality had decisive influence on perceived effects of crime/criminality on rural family livelihoods in Ogbomoso Agricultural zone of Oyo State. The study recommends the need to tackle rural crime effectively through adequate adherence to community rules and regulations so that the rural family could live in a relatively safe and low-crime environment to enhance rural family livelihoods. Keywords: Crime, criminality, livelihoods, rural family, preventive strategi

    The Role of Communication Channels in Promoting Sustainable Wood Waste Management in the Czech Republic

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    Sustainable wood waste management is critical for achieving the Sustainable Development Goals (SDGs), mainly responsible consumption and production (SDG 12) and climate action (SDG 13). This study investigated the role of communication channels in promoting sustainable wood waste management practices in the Czech Republic, utilizing survey data from 1050 respondents. Based on ordinary least squares (OLS) regression, the findings reveal that television is the most influential media source, significantly enhancing engagement in wood waste management practices (β = 0.0273, p < 0.10). Socio-economic characteristics, such as age (β = −0.0033, p < 0.001), gender (β = −0.0277, p < 0.10), and place size (β = 0.0150, p < 0.001), also play significant roles, with younger individuals and residents of larger communities showing higher engagement. However, the predominance of alternative disposal methods, such as burning, raises environmental concerns. The study emphasizes the importance of taking legislative measures that target the youth demographic, increase waste management infrastructure, especially in rural regions, and use television as a medium for information communication. These results contribute to the conversation about the bioeconomy and sustainable waste management while providing stakeholders and policymakers with valuable information

    Qualitative & Quantitative Phytochemical Constituents, GC-MS Analysis and Antibacterial Activity of the Aqueous Extracts of the Leaf and Flower of Blumea Aurita

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    This study investigates the qualitative and quantitative phytochemical composition, GC-MS profile, and antibacterial activity of aqueous extracts from the leaf and flower of Blumea aurita, a plant widely recognized in traditional medicine. The phytochemical screening revealed the presence of key bioactive compounds, including alkaloids, flavonoids, saponins, and terpenes—all known for their therapeutic significance. Quantitative analysis showed relatively balanced concentrations of these metabolites in the leaf extract, with alkaloids (0.88 mg/100 g) being the most abundant, followed closely by terpenes (0.798 mg/100 g), flavonoids (0.789 mg/100 g), and saponins (0.78 mg/100 g). GC-MS analysis identified 23 bioactive compounds, with squalene (25.25%), octacosane (9.07%), and 2,6-dimethyl-6 nitro-2-hepten-4-one (8.37%) as dominant constituents, many of which have documented antimicrobial properties. Antibacterial assays demonstrated that the extract exhibited considerable inhibitory effects against Gram-negative Escherichia coli and Pseudomonas aeruginosa, as revealed by their zones of inhibition, suggesting the presence of synergistic phytochemical interactions that enhance antibacterial efficacy. These findings validate the traditional use of B. aurita leaves and flowers in managing infections and highlight their potential as a source of natural antibacterial agents. The integration of phytochemical profiling in this work provides a scientific foundation for future pharmacological development and supports the role of Blumea aurita as a promising candidate in the search for plant-based therapeutics amidst growing concerns over antibiotic resistance

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