Josai University

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    7341 research outputs found

    Approaches to resolve multidrug therapy related adverse drug events using the Japanese Adverse Drug Event Report (JADER) database.

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    学位授与機関:城西大学 学位記番号:博乙第86号,学位の種別:博士(薬学), 学位授与年月日: 令和4年(2022年)9月17日 (88p.)博士(薬学)城西大

    Correction: COVID-19 pandemic vaccination strategies of early 2021 based on behavioral differences between residents of Tokyo and Osaka, Japan

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    The Original Article was published on 04 August 2022 : https://doi.org/10.1186/s13690-022-00933-z Following publication of the original article [1], the authors reported Fig. 3 was the wrong figure from another article due to a typesetting error. The correct Fig. 3 has been provided in this Correction. The original article [1] has been corrected

    “Extracurricular Activities” in Online Classes : Current Situation and Perspectives

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    特集 / Feature

    Implementation of Remote Education in Dietitian Training Programs ―Perspectives from practical education―

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    特集 / Feature

    Enhancement of skin permeation of fluorescein isothiocyanate-dextran 4 kDa (FD4) and insulin by thermalporation

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    Thermalporation has gained attention as a physical means to enhance skin permeation by creating micropores in the primary skin barrier, stratum corneum, which allows much higher permeation of middle and high molecular weight biopharmaceuticals. In the present study, a PassPort® system (PS) was used as a thermalporation device, and the obtained change in permeation resistance of drugs was evaluated using a parallel skin permeation-resistance model. In addition, the blood concentration-time profile after topical application of insulin was also investigated with the PS treatment. Fluorescein isothiocyanate-dextran (FD-4) and insulin were used as model middle molecular weight drugs. Micropores created by the PS treatment were measured using an optical microscope. An in vitro skin permeation and an in vivo pharmacokinetics experiments were done with FD-4 and insulin, respectively. Barrier function recovery after the PS treatment was evaluated with changes in the electrical skin resistance. About 960-fold higher skin permeation of FD-4 was observed by PSs treatment (4 milliseconds (ms), 200 micropores/cm2). A gradually increased blood concentration of insulin was observed by the PSs treatment, and the relative bioavailability of insulin was 21.1% compared with subcutaneous injection. Skin resistance value was dramatically decreased immediately after the PS treatment, but its value was turned into the initial one by 12 h. The thermalporation is effective for improving skin permeation of FD-4 and transdermal absorption of insulin. These results suggested that the PS treatment may be utilized to increase the skin permeation of topically applied FD-4 and insulin.8p. Article No.106096 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND licens

    Journal of Josai Community Liaison Center Annual Report 2021

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    編集:城西大学・城西短期大学地域連携センター紀要編集委員会 「城西大学坂戸キャンパス周辺の湧水を起源とする水環境」についてはSummaryのみ掲載(p.102-103)。「※本稿は、著者の意向により、オンライン版では非公開とする。なお、冊子版は、城西大学坂戸キャンパス水田記念図書館および国立国会図書館で閲覧可能である。また、日本語のフルペーパーを希望される方は、代表著者である城西大学薬 学部教授の真野博まで連絡されたい(以下のメールアドレス:★を@に変える)。h-mano★josai.ac. Jp」の記述あ

    Journal of Josai Community Liaison Center Annual Report 2021

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    編集:城西大学・城西短期大学地域連携センター紀要編集委員

    Preface

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    編集:城西大学・城西短期大学地域連携センター紀要編集委員

    Report of community activities through the children cafeteria in the Nishisakado area

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    地域活動ノート / Notes 編集:城西大学・城西短期大学地域連携センター紀要編集委員

    Promotion and support of lifelong learning for registered dietitians assigned to pharmacies - Collaboration between Pharmacy Registered Dietitian Study Group and Department of Clinical Dietetics and Human Nutrition

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    地域教育実践報告 / Reports 編集:城西大学・城西短期大学地域連携センター紀要編集委員

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