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Nitric oxide bioavailability for red blood cell deformability in the microcirculation: A review of recent progress
Get PDFThe rheological properties of red blood cells (RBCs) play an important role in their microcirculation. RBCs can elastically deform in response to mechanical forces to pass through narrow vessels for effective gas exchange in peripheral tissues. Decreased RBC deformability is observed in lifestyle-related diseases such as diabetes mellitus, hypercholesterolemia, and hypertension, which are pathological conditions linked to increased oxidative stress and decreased nitric oxide (NO) bioavailability. Redox-sensitive cysteine residues on RBC cytoskeletal proteins, such as α- and β-spectrins, responsible for membrane flexibility, are affected by prolonged oxidative stress, leading to reversible and irreversible oxidative modifications and decreased RBC deformability. However, endogenously, and exogenously generated NO protects RBC membrane flexibility from further oxidative modification by shielding redox-sensitive cysteine residues with a glutathione cap. Recent studies have shown that nitrate-rich diets and moderate exercise can enhance NO production to increase RBC deformability by increasing the interplay between RBCs and vascular endothelium-mediated NO bioavailability for microcirculation. This review focuses on the molecular mechanism of RBC- and non-RBC-mediated NO generation, and how diet- and exercise-derived NO exert prophylactic effects against decreased RBC deformability in lifestyle-related diseases with vascular endothelial dysfunction.Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Survey on Pharmacist Factors Hindering the Progress of the Family Pharmacist System
Get PDFかかりつけ薬剤師制度は，患者の服薬情報の一元的・継続的な把握と薬学的管理・指導を実施することで，患者の薬物療法の安全性および有効性の向上を目的としている．しかし，かかりつけ薬剤師指導料の算定率は低い水準にとどまっている．これまで，かかりつけ薬剤師制度が進展しない患者側の要因については調査されているものの，薬剤師側の要因については調査されていない．そこで，かかりつけ薬剤師の業務および施設基準に対して，薬剤師が負担と感じている項目についてインターネットを用いて調査し，かかりつけ薬剤師制度の進展を阻害する薬剤師側の要因を検討した．その結果，負担感の高い項目として「時間外の相談対応」「地域活動への取り組み」「患者負担額」「在宅医療」「調剤後の電話による確認」が抽出された．これらの項目が，かかりつけ薬剤師制度の進展を阻害する要因であると推測される．The family pharmacist system aims to improve the safety and efficacy of drug therapy for patients. It provides an integrated and continuous understanding of patients’ medication information and pharmaceutical management and instructions. However, the rate of payment for family pharmacist instruction has not increased. Thus far, there have been surveys on patient factors preventing the progress of the family pharmacist system, but there have been no surveys on the pharmacist factors. For this reason, we conducted an Internet-based survey on the factors pertaining to their duties and the facility standards that family pharmacists find burdensome. We examined the pharmacist factors that hinder the progress of the family pharmacist system. “After-hours consultation services,”“participation in community activities,”“increase in patient cost sharing,”“home medical care,” and “telephonic confirmation after dispensing” were factors perceived as highly burdensome. These items were identified as factors that hinder the progress of the family pharmacist system
The COVID-19 Crisis and Transformation of Capitalism : Beyond the “Crisis of Care”
Get PDFThe COVID-19 pandemic has given us an opportunity to rethink various forms of institutions in our societies and the framework itself which shapes our “society”. In this paper, we reexamine the relationship between socio-economy and the care from some points of view. First, to stabilize recent uncertain and precarious forms of employment, some kind of Basic Income is needed. Beyond some difficulties（ BI and a disincentive to work, BI and taxes, and so on）, Basic Service rather than Basic Income should be discussed in our civil society. Second, taking the continuous reproduction of the life world into consideration, we could deliberate on the possible （or better） relationship between the economics and the life world including caregiving （from medical services to social welfare）. Care could be thought as a blind spot of modern economics. In contrast, the analysis of capitalism could give us a new perspective. Capitalism as an “institutionalized social order”（ N. Fraser） has the radical contradiction that it needs the care to sustain itself and expropriates and undermines the care. Changing from the economy which is based on the production of commodities to the one which focuses on the social reproduction could be the alternative after the “corona crisis”.通巻第45号, 論文 / Article
Analysis of a survey of leftover school lunches at elementary and junior high schools in Tokigawa Town - Request from School lunch center
Get PDF地域連携報告 / Reports 編集：城西大学・城西短期大学地域連携センター紀要編集委員
Survey of actual conditions and verification of effective management methods in Local Health and Nutrition Policy Promotion Program - Case study of “Kids Work Plus”, a child-rearing activity in Sakado City
Get PDFThe eating habits of children (school children and adolescents) are more important than adults be cause they not only maintain life but also form the basis of growth and development. On the other hand, lack of exercise caused by a decrease in the physical strength of a child has an adverse effect on health aspects such as childhood obesity and mental aspects such as a decrease in motivation and vitality. Therefore, it is important to create an environment where children can maintain a healthy diet and play outdoors and play sports. In this study, we conducted a social survey of participants and operators of the “Kids Work Plus” health promotion and environment creation program aimed at improving physical fitness and creating a place for children around Josai University, and examined the content of their activities. The children who participated during the survey had good beliefs and eating behaviors. In the results of the questionnaire to the operators, there were many positive answers, and it was found that the awareness, motivation, and willingness to collaborate with local children as business supporters were high. It was found that parents are highly interested and satisfied, and that child-rearing activities that serve as a place for dietary education, exercise, and multi-generational communication are required. In this way, community symbiosis projects in which families, schools, and communities are linked are useful for issues such as modern nuclear families, isolation of childcare, and child poverty. And in order for participants to continue, it is necessary to consider the activity content that considers the child’s age, understanding, and behavior. In particular, it was found that it is important for the operators to confirm the planning intention, share information on the activity contents, and have a preliminary meeting.査読論文 / Peer-Reviewed Article 編集：城西大学・城西短期大学地域連携センター紀要編集委員
Development of Subcutaneously Administered Formulations Containing Non-Lamellar Liquid Crystal-Forming Lipids
Get PDF学位授与機関：城西大学 学位記番号：博甲第105号，学位の種別：博士（薬科学）， 学位授与年月日： 令和4年(2022年)3月17日 (95p.)博士（薬科学）城西大
Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives
Get PDFBackground: Very few papers covering the anticancer activity of azulenes have been reported, as compared with those of antibacterial and anti-inflammatory activity. This led us to investigate the antitumor potential of fifteen 4,6,8-trimethyl azulene amide derivatives against oral malignant cells. Methods: 4,6,8-Trimethyl azulene amide derivatives were newly synthesized. Anticancer activity was evaluated by tumor-specificity against four human oral squamous cell carcinoma (OSCC) cell lines over three normal oral cells. Neurotoxicity was evaluated by cytotoxicity against three neuronal cell lines over normal oral cells. Apoptosis induction was evaluated by Western blot and cell cycle analyses. Results: Among fifteen derivatives, compounds 7, 9, and 15 showed the highest anticancer activity, and relatively lower neurotoxicity than doxorubicin, 5-fluorouracil (5-FU), and melphalan. They induced the accumulation of a comparable amount of a subG1 population, but slightly lower extent of caspase activation, as compared with actinomycin D, used as an apoptosis inducer. The quantitative structure–activity relationship analysis suggests the significant correlation of tumor-specificity with a 3D shape of molecules, and possible involvement of inflammation and hormone receptor response pathways. Conclusions: Compounds 7 and 15 can be potential candidates of a lead compound for developing novel anticancer drugs.Licensee MDPI, Basel, Switzerland.This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
A Report on Hybrid-Flexible Class Practice under Covid19 : Focusing on Freshmen-Oriented First-Year Japanese Courses
Get PDF報告 コロナ禍における授業（２） / Reports on Some Styles of Classes under the COVID-19 Calamity (2