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Development and Characteristics of Day Trip Tourist Attraction in Hanno area, Saitama Prefecture Focus on the Descriptions in Travel Guides
Get PDF論文 / Treatise
Early Medieval Stone Carvings From the Lower Rhone Region of France : A Study of Rosette Motifs
Get PDF西ヨーロッパの初期中世の石造彫刻の年代比定は概して簡単ではない。特に地方工房における制作である場合、検証のための根拠が乏しいことが多い。本論考はニームのギュイヌメール遺跡から2016 年に出土した彫刻石材と、ローヌ河下流領域に残されている比較作例の研究調査の報告である。「ロゼット」と現在呼ばれる円形の装飾モティーフが、初期中世の地元工房の彫刻モティーフのレパートリーとして頻繁に登場するようになった状況について分析し、時代的・地域的にさらに広い比較研究を行いながら、当モティーフと地方工房の活動についての試論を述べる。It can be difficult to date or verify the origin of early medieval Western Europe stone carvings, especially if they were originally crafted in local workshops. This report compares the results of an investigation of stone carvings excavated in 2016 from the archeological site of Rue Guynemer, Nimes, to examples found in the lower Rhone region. The author analyses how the decorative motif, or rosette, became more common in the repertoire of early medieval sculptors, especially those operating regional workshops, through detailed comparative research of several regions across different epochs.論文 / Article
20th エムオーエー ビジュツカン サカド ツルガシマ ジドウ サクヒン テン ポスター
Get PDF開催日 ： 2022年10月29日（土）～10月30日（日） 開館時間 ： 午前9時30分～午後4時30分 ※今年度は水田美術館が構内工事の関係で休館中のため、学園祭開催時に特別開館し、2日間のみの開催となります。観覧料 ： 無料 会場 ： 城西大学水田美術館２階ギャラリー1、2 後援：文部科学省、外務省、厚生労働省、農林水産省、環境省、埼玉県、埼玉県教育委員会、埼玉県議会、坂戸市、鶴ヶ島市、坂戸市教育委員会、鶴ヶ島市教育委員会、全国連合小学校長会、日本ユネスコ国内委員会、公益社団法人日本PTA全国協議会、公益財団法人海外日系人協会、公益社団法人全国子ども会連合会、公益財団法人ボーイスカウト日本連盟、全国新聞社事業協議会、産経新聞社さいたま総局、埼玉新聞社、テレビ埼玉、城西大学水田美術
Issues of Japan’s Policy to Prevent the Loneliness and Isolation of the Elderly and China’s Suggestions
Get PDF近年，新型コロナウイルスの流行により人間の孤独・孤立の問題が注目を集めている。特に世界一の高齢化率である我が国においては，家庭構造の変化に伴う独居高齢者の増加などから高齢者の孤独・孤立の問題がより深刻化しそうだ。こうした背景をもとに政府は地域包括ケアシステムの構築推進や孤独・孤立対策担当室の設置という取り組みを行っているが，十分な効果が現れていない。本稿では，まず日本における高齢者の孤独・孤立の問題の背景と実態を把握する。そのうえで，高齢者の孤独・孤立問題に対する各方面の取り組みとその効果を分析し，それぞれの政策課題を検討する。最後に，こうした日本の政策課題を踏まえて，中国における健康増進や高齢者介護の政策について「健康中国2030」と「9073 モデル・智慧養老（インテリジェント老後）」を考察し，日本が中国の政策から学ぶことのできる有益な示唆を考える。In recent years, the coronavirus epidemic has drawn attention to the problem of human loneliness and isolation around the world. Especially in Japan, which has the highest aging rate in the world, there is a risk that the problems of loneliness and isolation among the elderly will become more serious due to changes in the family structure and the increase in the number of elderly living alone. Against this background, the government has implemented policies such as promoting the construction of a comprehensive community care system and establishing an office to deal with loneliness and isolation, but these efforts have not produced sufficient results. In this paper, we first grasp the background and actual situation of loneliness and isolation among the elderly in Japan. After that, we will organize various efforts and their effects on the loneliness and isolation problem of the elderly, and examine each policy issues. Finally, based on these policy issues in Japan, We consider China’s policies for health promotion and elderly care, using examples of “Health China 2030”, “9073 Model”, and “Smart Elderly Care”, and discuss what Japan can learn from China’s policies.論
Verification of nanoparticle formation, skin permeation, and apoptosis using as a methoxyflavonoid derivative
Get PDFPurpose: Nobiletin (NOB), a polymethoxyflavonoid, is known for its antioxidant and anti-inflammatory effects and has antitumor activity. However, its poor solubility and low bioavailability pose a significant challenge in its delivery. In this experiment, NOB was added to Soluplus® (Sol)/l-ascorbyl 2,6-dipalmitate (ASC-DP) as a ternary system, and Sol/ASC-DP/NOB nanoparticles were obtained using the hydration method. The purpose of this study was to enhance the solubility of NOB, apply it for skin permeation, and improve antitumor activity. Methods: The preparation of Sol/ASC-DP/NOB nanoparticles was attempted using the hydration method, and particle size, zeta potential, and stability tests were performed to evaluate the formation of nanoparticles. 1H-1H NOESY/ROESY NMR spectral measurements were also performed to identify molecular interaction between NOB and Sol/ASC-DP. To evaluate its functionality, DPPH radical scavenging, skin permeation, fluorescence microscopy, and cell viability analyses were performed. Results: The particles were approximately 100 nm in size in the ternary system (weight ratio (Sol/ASCDP/NOB=8/1/1)) and were relatively stable for approximately 7 days at 25 °C under light-shielded conditions. From the NMR spectrum measurements of Sol/ASCDP/NOB, a cross-peak was observed between the –OCH3 group: C6,8 (3.8 ppm) derived from NOB, the methyl group (2.0 ppm) derived from Sol, and the side chain portion (1.2 ppm) derived from ASC-DP. Cross-peaks were observed between the polyethylene glycol (PEG) backbone of Sol (3.6 ppm) and the side chain of ASC-DP (0.8–1.2 ppm). The formation of Sol/ASC-DP/NOB nanoparticles facilitated its skin permeation, and fluorescence microscopy confirmed improved permeation. The DPPH radical scavenging test revealed that Sol/ASC-DP/NOB had an IC50 of 46.7 μg/mL. Cell viability assays showed a 20–40% decrease in cell viability with the addition of Sol/ASC-DP/NOB at 0.1 mg/mL. Conclusion: Sol/ASC-DP/NOB nanoparticles were successfully prepared, and these were found to inhibit melanin formation and have antitumor activity.p.18 Article number: 17 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/
Study of Polymer Nanofilms Using for High-Throughput Screening in the Development of Transdermal Therapeutic System
Get PDFWe investigated polymer nanofilm (PNF) for use in high-throughput screening (HTS) to promote the development of transdermal therapeutic systems (TTS). The drug permeability of PNF with a 1 : 1 weight mix ratio of poly(L-lactic acid) (PLLA) and poly(methylhydrosiloxane) (PMHS) (PLLA/PMHS (1/1) PNF) and Strat-M® of the transdermal diffusion test membrane, was evaluated using 12 kinds of drugs with the logarithmic value of n-octanol/water partition coefficients of −4.70 to 3.86. The lag time of PLLA/PMHS (1/1) PNF made via polymer alloying was significantly shorter than that of Strat-M® for 10 drug types, and the formation of a highly diffusible PMHS-rich phase accompanying the formation of a sea–island structure was suggested as a contributing factor. Additionally, a high correlation was confirmed between the measured value for the logarithm of the apparent permeability coefficient of PLLA/PMHS (1/1) PNF and the literature values for the logarithm of the apparent permeability coefficient of human skin (r = 0.929). This study shows that PLLA/PMHS (1/1) PNF can reliably predict drug permeability in human skin and can potentially be used in HTS for developing TTS
Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study
Get PDFNonalcoholic steatohepatitis (NASH) is a chronic liver disease that leads to liver cirrhosis and hepatocellular carcinoma. Endothelial dysfunction caused by hepatic lipotoxicity is an underlying NASH pathology observed in the liver and the cardiovascular system. Here, we evaluated the effect of dietary nitrite on a rat NASH model. Stroke-prone, spontaneously hypertensive 5/Dmcr rats were fed a high-fat/high-cholesterol diet to develop the NASH model, with nitrite or captopril (100 mg/L, each) supplementation in drinking water for 8 weeks. The effects of nitrite and captopril were evaluated using immunohistochemical analyses of the liver and heart tissues. Dietary nitrite suppressed liver fibrosis in the rats by reducing oxidative stress, as measured using the protein levels of nicotinamide adenine dinucleotide phosphate oxidase components and inflammatory cell accumulation in the liver. Nitrite lowered the blood pressure in hypertensive NASH rats and suppressed left ventricular chamber enlargement. Similar therapeutic effects were observed in a captopril-treated rat NASH model, suggesting the possibility of a common signaling pathway through which nitrite and captopril improve NASH pathology. In conclusion, dietary nitrite attenuates the development of NASH with cardiovascular involvement in rats and provides an alternative NASH therapeutic strategy.p.16 Article number: 2931 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)