7341 research outputs found
Sort by
Mechanism of Preventing Chronic Renal Failure Progression by Intake of Polyunsaturated Fatty Acid
Get PDF学位授与機関：城西大学 学位記番号：博甲第110号，学位の種別：博士（薬科学）， 学位授与年月日： 令和5年(2023年)3月17日 (118p.)博士（薬科学）城西大
Survey analysis on self-evaluation in written expression－Japanese academic writing in first-year university education－
Get PDF研究ノート / Research Note
Involvement of restoration of cerebral blood flow and maintenance of eNOS expression in the prophylactic protective effect of a novel ferulic acid derivative FAD012 against ischemia/reperfusion injury in rats
Get PDFTissue plasminogen activator, aiming to restore cerebral blood flow (CBF), has been used for acute ischemic strokes in clinics; however, its narrow therapeutic time window remains a serious concern. To develop novel prophylactic drugs to alleviate cerebral ischemia/reperfusion injuries, ferulic acid derivative 012 (FAD012) was synthesized and showed comparable antioxidant properties to ferulic acid (FA) and probably possesses the potent ability to cross the blood–brain barrier. A more potent cytoprotective effect of FAD012 against H2O2-induced cytotoxicity in PC12 cells was also observed. In vivo toxicity was not observed in rats given a long-term oral administration of FAD012, indicating its good tolerability. A one-week-course oral administration of FAD012 significantly alleviated middle cerebral artery occlusion (MCAO)-induced cerebral ischemia/reperfusion injuries in rats, accompanied by the restoration of CBF and endothelial nitrogen oxide synthetase (eNOS) expression. Treatment with FAD012 significantly restored the cell viability and eNOS expression damaged by H2O2, used to mimic MCAO-triggered oxidative stress, in rat brain microvascular endothelial cells. Our findings suggested that FAD012 protected the viability of vascular endothelium and maintained eNOS expression, ultimately contributing to the restoration of CBF, and may provide a rationale for the development of FAD012 into an effective prophylactic drug for patients at high risk of stroke.p.18 Article number: 9663 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains
Get PDFCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread as a pandemic and caused damage to people’s lives and countries’ economies. The spike (S) protein of SARS-CoV-2 contains a cleavage motif, Arg-X-X-Arg, for furin and furin-like enzymes at the boundary of the S1/S2 subunits. Given that cleavage plays a crucial role in S protein activation and viral entry, the cleavage motif was selected as the target. Our previous fluorogenic substrate study showed that osthole, a coumarin compound, inhibits furin-like enzyme activity. In this study, we examined the potential activities of 15 compounds with a structure-activity relationship with osthole, and evaluated their protective ability against SARS-CoV-2 infection. Of the 15 compounds tested, compounds C1 and C2 exhibited the inhibitory effects of osthole against furin-like enzymatic activity; however, little or no inhibitory effects against furin activity were observed. We further examined the inhibition of SARS-CoV-2 activity by compounds C1 and C2 using a Vero E6 cell line that expresses the transmembrane protease serine 2 (TMPRSS2). Compounds C1, C2, and osthole effectively inhibited SARS-CoV-2 infection. Therefore, osthole and its derivatives can potentially be used as therapeutic agents against SARS-CoV-2.Article number: 115940 (2023) Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
EU Immigration Control Law and Hungarian Law
Get PDF2015 年から始まる 「欧州難民危機」 は、 欧州、 特に EU の制度を遥かに凌駕する 「難民」 が EUに殺到し、 EU 法や国際法、 また、 各国国内法をはじめとする種々の法的枠組の限界を露呈した。特に、 1951 年の難民条約や、 これに続く議定書が定義するもの以外の、 「新形態の難民」 が、 多く難民申請を行うことになり、 法的枠組と同時に、 それらの人々の地位も不安定なものにしている。本稿では、このような「新形態の難民」と、難民条約等が定義する難民を区別し、「新形態の難民」を「難民」として表記し、この「難民」を受け入れる国々のうち、「難民」を受け入れないとして批難されるハンガリーに着目して、 その状況、 対応、 そして課題について考察するものである。1．はじめに 2．「難民」とは、誰のことなのか 3．欧州に於ける「難民」問題の経緯と現在の状況 4．国際的な法的枠組み 5．ハンガリー国内法に於ける法的枠組 6．検討 7．むすびに In recent years, numbers of refugees to Europe from Syria, the Middle East, North Africa（especially Libya）,have been increasing to Europe. The term “refugee” is extremely ambiguous, and even though it is used by many researchers, the definition is not fixed. In this paper, the author will first define the term and then focus particularly on Hungary and how that country responds to its refugee problem. The author will also clarify how Hungarian law and politics are coping with the refugee problem and consider how EU law and politics are related.1. Introduction 2. Defining a Refugee 3. Background and Current Status of Refuges and the Problem in Europe 4. European and International Legal Systems 5. Framework of Domestic Law in Hungary 6. Considerations 7. Conclusion論文 / Article