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Study on therapeutic mechanism of Kshara Sutra medicinal thread in the treatment of anal fistula
Get PDF本研究では痔瘻モデルラットを用い痔瘻治療糸、クシャーラ・スートラ（KS）の作用について評価・検討を行った。KS処置によって炎症マーカーであるIL-6やTNF-αの発現量がわずかに増加していること、瘻管の上皮層が欠損または著しく薄くなる様子が認められた。また、痔瘻の原因菌に対して低濃度での抗菌活性を示さなかった。KSによる瘻管上皮層の欠損や形成阻害が、治療期間の短期化に寄与すると考えられる。In this study, we evaluated the effects of Kshara Sutra (KS), a therapeutic thread for anal fistula, in a rat model of fistula, and found that KS treatment resulted in a slight increase in the expression of inflammatory markers IL-6 and TNF-α, and a loss or significant thinning of the epithelial layer of the fistula tract. In addition, KS showed no antimicrobial activity at low concentrations against anal fistula pathogens.The loss or inhibition of the formation of the epithelial layer of the fistula tract by KS may contribute to a shorter treatment period.科学研究費助成事業研究成果報告書 研究種目：若手研究, 研究期間：2021～2022, 課題番号：21K16435 研究分野：生薬、薬用植物、伝統医学, 研究者番号：00825862. 6p
Three dimensional nanostructure fabrication by using protein crystals as the templete
Get PDFタンパク質結晶は溶媒チャンネルと呼ばれる三次元ナノ細孔構造を有し、かつその細孔は表面のタンパク質に由来するキラル空間であるため、タンパク質結晶は新規かつ高機能な多孔質材料である。本研究ではニワトリ卵白由来リゾチーム結晶の細孔に発光性の機能性分子を高密度に集積することで共鳴エネルギー移動や三重項-三重項消滅フォトンアップコンバージョンなど希薄溶液では生じない現象を見い出した。また結晶細孔内に導入した金・銀錯体がタンパク質の働きにより還元され金・銀ナノ粒子を形成すること、その成長をレーザー光照射で迅速化できることを示した。タンパク質結晶を多孔性材料・ミクロ反応容器として活用する方法を切り開いた。Protein crystals possess distinguished three-dimensional structures that contain well ordered nanoporous solvent channels that are typically 0.5-10 nm in diameter. From this viewpoint, structural similarities to nanoporous materials, such as zeolite, mesoporous silica, and metal organic frameworks (MOF), are noteworthy. It is expected that similarly to such nanoporous materials, protein crystals will be employed in a broader range of applications. In this prject, we aim to fabricate novel three-dimensional nanostructured materials by exploiting the function of protein crystals. We have found that resonant energy transfer and triplet-triplet annihilation photon upconversion in the nanopores of protein crystals by loading functional molecules in high density. In addition, we have fabricated gold/silver nanoparticles in the nanopores, which can be accelerated by photo-irradiation. Such foundings are based on the characteristics of the protein crystals.科学研究費助成事業研究成果報告書 研究種目：基盤研究(C)（一般）, 研究期間：2020～2022, 課題番号：20K05269 研究分野：ナノ材料科学, 研究者番号：30455448. 7p
A stugy on the information provision methods for tourists during disasters using an agent approach
Get PDF(a系統) 観光客へのサンプリング調査研究、観光客による一斉帰宅緩和のための震災時帰宅行動研究、(b系統) 観光客避難シミュレーション研究、(c系統) エージェントシミュレーションによって避難計画の評価を行うゲーミングシミュレーション研究を実施した。その成果として、aからcを並走させることで、本ゲーミングがコミュニティ防災の要件を満たすことを明らかにした。This study conducted (a) a sampling survey study of tourists and a study of tourist return home behavior during an earthquake to mitigate the simultaneous return home by tourists, (b) a study of tourist evacuation simulation, and (c)gaming simulation to evaluate evacuation plans by agent simulation were clarified. By running a-c in parallel, it was revealed that this gaming meets the requirements for community disaster prevention.科学研究費助成事業研究成果報告書 研究種目：若手研究, 研究期間：2019～2022, 課題番号：19K15267 研究分野：エージェントシミュレーション、シミュレーション・ゲーミング、社会工学, 研究者番号：20826945. 5p
The Significance of Concerted Actions to the Japanese Electronics Industry during the Period of Rapid Economic Growth
Get PDF論文 / Treatise
The Autobiography of Edward, Lord Herbert of Cherbury Translated into Japanese: (5)“ Adventures of His Military Volunteer Service in the Continent, and His Appointment as English Ambassador to France”
Get PDF研究ノート / Research Not
A Policy Proposal For Regional Collaboration: Ideal Attributes of Collaborators and Agencies
Get PDFThe purpose of this study is to identify the qualities and roles required for regional collaboration.Also, I would like to make policy recommendations necessary for universities to engage in regional cooperation. A coordinator role is needed for university-community partnerships, such as in manag ing community activities, securing volunteers, and building networks with residents and various or ganizations. For universities to assume this role, university teachers need to have certain qualifica tions.In the future, regional cooperation will require university officials and the local community to work together. Universities must also contribute as a social resource. For the region to develop in the fu ture, university teachers will need to be able to build relationships of trust between the region and the university and to manage communication.論文 / Article 編集：城西大学・城西短期大学地域連携センター紀要編集委員
Activity Report of PBL with Community Collaboration - Based on the review of major projects in 2022 by seminar students
Get PDF地域教育実践報告 / Reports 編集：城西大学・城西短期大学地域連携センター紀要編集委員
