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The Enhancing Effects of S-Allylcysteine on Liver Regeneration Are Associated with Increased Expression of mRNAs Encoding IGF-1 and Its Receptor in Two-Thirds Partially Hepatectomized Rats
Get PDFTwo-thirds partial hepatectomy (PHx) was performed in rats, and the differences in effects between S-allylcysteine (SAC) and other sulfur-containing compounds on regeneration of the remaining liver and restoration of the injury were examined. Three days after two-thirds PHx, rats treated with 300 mg/kg/d, per os (p.o.) SAC showed a 1.2-fold increase in liver weight per 100 g body weight compared with saline-treated controls. In contrast, S-methylcysteine (SMC) (300 mg/kg/d, p.o.) or cysteine (Cys) (300 mg/kg/d, p.o.) did not have a regeneration-promoting effect. In the comparison with control rats, the regenerating liver of SAC-treated rats showed a significantly higher 5-bromo-2′-deoxyuridine labeling index on day 1. In contrast, serum alanine aminotransferase activity, which increases following PHx, was significantly inhibited by SAC and SMC (but not Cys) on day 1 after two-thirds PHx. In addition, SAC induced increases in insulin-like growth factor (IGF)-1 and its receptor mRNA expressions at 1 h after two-thirds PHx, and it increased phosphorylation of extracellular signal-regulated kinase (ERK)2 and Akt at 3 h after two-thirds PHx without affecting serum growth hormone levels. These results demonstrate that SAC is a mitogenic effector of normal remnant liver and promotes recuperation of liver function after two-thirds PHx. Moreover, SAC-induced proliferative effects are mediated via increased mRNA expressions of IGF-1 and its receptor and subsequent phosphorylation of ERK2 and Akt.UB05240020<Pre 医中誌
ゲーム リロン ト カンセンショウ リュウコウ シミュレーション
Get PDF2020年度城西大学公開講座 第3回 発表資料（13p.）. 開催日時：2020年12月16日（水） 13：50～ 15：10 会場：城西大学 清光会館２階ホール 主催：城西大学・城西短期大学. 後援：坂戸市・鶴ヶ島市・日高市・川越市・飯能市・東松山市・毛呂山町・越生町・鳩山町・川島町の各教育委員会、彩の国大学コンソーシアム、埼玉新聞社、埼玉東上地域大学教育プラットフォーム 受講料：無料 ※本講座は埼玉県の「埼玉まなびぃプロジェクト協賛事業」です
Prediction of Molecular Properties by Molecular Orbital Calculations and Machine Learning
Get PDFThe values of the internuclear distances and the dipole moments of 14 small molecules have been estimated by machine learning with only molecular orbital energies as the explanatory variables. We use four regression methods, partial least square (PLS), random forest (RF), Radial Basis Function Kernel Regularized Least Squares (krlsRadial), and Baysian Regularized Neural Networks (BRNN) and we report only BRNN results for the internuclear distances, and PLS results for the dipole moments. The coefficients of determination for the internulear distances and the dipole moments are 0.9318 and 0.7265, respectively. It has been proved that the internuclear distances and the dipole moments can be predicted by the molecular orbital energies only
Luminescent properties of a polymeric copper(I)-bromide complex in a PMMA film
Get PDFThe [Cu2Br2(DIB)2(PPh2)2]n complex, obtained by the reaction between [Cu4Br4(PPh3)4] and 1,4-diisocyanobenzene (DIB), was found to have a bridged polymeric structure with a planar {Cu2Br2} core. The compound exhibited bluish-green (λmax = 498 nm) and green (λmax = 515 nm) luminescence at 295 and 77 K, respectively, corresponding to the emissions from XLCT (HE band) and (X + M)LCT (LE band), respectively. The dual emission, which is attributed to the luminescence from both bands, was observed at around 178 K. The complex also displayed a change in luminescence color from bluish-green to yellow (λmax = 529 nm) upon applying external mechanical stimuli. The film containing [Cu2Br2(DIB)2(PPh2)2]n was prepared by a cast method using polymethyl methacrylate as a binding agent. The rubbed part of the film turned yellow and the other parts maintained bluish-green luminescence. Restoration of the initial color was feasible by annealing, even in film state.7p. ORCID iDs Mitsuaki Suzuki https://orcid.org/0000-0001-7226-266
Rethinking the criticism of Manga
Get PDF本研究は，マンガに対するネガティブな評価の背景と，マンガが及ぼすポジティブな影響について検討することを通して，マンガ批判の妥当性を論じ，書籍に対するマンガの地位を再評価することを目的とした。マンガに対する批判，規制は，主観的な印象に基づくもので，科学的な根拠に欠けることが示された。一方，マンガの表現形式が，学習内容の理解や記憶保持にとって効果的であることや，マンガがさまざまな形で自己形成に影響を及ぼしていることは，実証的な研究を通して明らかにされてきた。以上のことから，わが国で繰り返されてきたマンガ批判は妥当とは言えず，マンガは，少なくとも書籍と同等の位置づけを与えられるべきとの結論に至った。経済学部19年卒 学生論文, 指導教員 浅原 知
Preparation of niosome complexes for gene transfer and targeting to tumor cells by complexing with hyaluronic acid
Get PDF学位授与機関：城西大学 学位記番号：博甲第96号，学位の種別：博士（薬学）， 学位授与年月日： 令和2年(2020年)3月17日 (101p.) 2021年3月31日まで要旨のみ公開博士（薬学）城西大
Syntheses and crystal structures of two piperine derivatives
Get PDFThe title compounds, 5-(2H-1,3-benzodioxol-5-yl)-N-cyclohexylpenta-2,4-dienamide, C18H21NO3 (I), and 5-(2H-1,3-benzodioxol-5-yl)-1-(pyrrolidin-1-yl)penta-2,4-dien-1-one C16H17NO3 (II), are derivatives of piperine, which is known as a pungent component of pepper. Their geometrical parameters are similar to those of the three polymorphs of piperine, which indicate conjugation of electrons over the length of the molecules. The extended structure of (I) features N—H O amide hydrogen bonds, which generate C(4) [010] chains. The crystal of (II) features aromatic π–π stacking, as for two of three known piperine
polymorphs
Effect of Rubbing on the Distribution of Topically Applied Drugs into the Hair Follicles
Get PDFRubbing actions are often conducted to apply topical formulations onto the skin. Although rubbing was found to increase the skin permeation of drugs, few reports have revealed whether rubbing enhanced either drug permeation through the stratum corneum (SC) or hair follicles (HFs) pathways, or through both. In the present study, we investigated the effects of rubbing on caffeine (CAF) distribution in the SC and HFs. The effect of rubbing direction on the skin penetration of CAF was also investigated. The skin concentration of CAF and its cumulative permeation amount were increased clearly by rubbing. More than six times higher CAF concentrations in the viable epidermis and dermis were observed 5 min after rubbing application compared with no rubbing. On the other hand, slightly increased CAF concentrations were observed in the SC, suggesting that CAF was delivered through the HF pathway by rubbing. Rubbing against the natural hair direction provided the highest skin permeation as well as skin concentrations. Changes in the morphology of the HF opening area might be related to the enhancement effect. These results may provide useful information to understand the effect of rubbing on the skin permeation of applied drugs