7341 research outputs found
Sort by
Rotaxa-polymeric-gelation of acrylamides with vinyl-β-cyclodextrin
Get PDFPreviously, we have reported a single-step preparation method for a topological gel by copolymerizing isoprene and vinyl-modified β-cyclodextrin (V-β-CyD). In the prepared gel, the vinyl part of V-β-CyD consists a part of the copolymer chain, and the β-CyD part includes another copolymer chain, thus V-β-CyD works as a cross-linker. We call the procedure rotaxa-polymeric-gelation (RPG) because polymerization, rotaxane formation, and gelation proceed simultaneously. In this study, we applied acrylamide (AAm) instead of isoprene for RPG, and successfully obtained highly swellable hydrogel. By contrast, a combination of V-β-CyD and N-isopropylacrylamide (NIPAAm) was not suitable for RPG because NIPAAm and cavity of β-CyD were mismatched in size. In addition, we prepared three-component gels. Among of them, gels composed of NIPAAm, isoprene, and V-β-CyD showed thermo-responsiveness by reflecting the character of polyNIPAAm. These results provide an insight for usage of vinyl monomers for RPG strategy
Differential Equations and Representation Theory : Proceedings of JMM Workshop on Differential Equations and Representation Theory Festschrift in Honor of Toshio Oshima, December 26-27, 2018 Josai University
Get PDFUrinary Bile Acid Shows Diurnal Fluctuation and Phase Shift with Daytime-Restricted Feeding in Rats
Get PDFDysregulation of the biological clock disrupts the homeostasis of physiological functions, which may lead to the development of various disorders. To investigate the relationship between biological rhythms and disorders, an efficient monitoring method of the biological clock is necessary. In this study, we analyzed the circadian rhythmicity profile of bile acids in urine and investigated whether urinary bile acid (UBA) could reflect the circadian rhythm in liver physiology. Male Wistar-Hannover rats were maintained in metabolic cages under ad lib feeding and later subjected to restricted feeding (in which rats were fed only during light periods). Excreted urine was collected in each session, and bile acid contents were analyzed via an enzyme-based total bile acid assay. UBA content showed diurnal fluctuations under both ad lib and restricted feeding conditions and reached a peak during the dark period of ad lib feeding. In contrast, with restricted feeding, the peak was observed during light periods. Restricted feeding induced an 8-12 h phase shift. Diurnal fluctuation and phase shift by restricted feeding are distinctive features controlled by biological clocks in peripheral tissues. Since bile acids are synthesized in the liver, we propose that UBA might reflect the circadian fluctuation in liver physiology
Theoretical Study on Antioxidant Properties of Ferulic Acid
Get PDFFerulic acid is known to have strong antioxidant properties. In the present study, we investigate the electronic structures of ferulic acid and its radical species extracting the hydrogen atom from its phenolic hydroxyl group. The relation of the results by several machine learning models using R/caret package, such as partial least squares, random forest, radial basis function kernel regularized least squares, and baysian regularized neural network, with the radical scavenging activity with the DPPH reagent, IC50, measured by Sakamoto et al. is discussed. We found all four methods gave reasonable correlation coefficients which means the possible prediction of the IC50 values with the results of the molecular orbital calculations only.速
Protective effects of oral supplementation of sodium nitrite on animal models with cardiovascular and respiratory diseases
Get PDF学位授与機関：城西大学 学位記番号：博乙第83号，学位の種別：博士（薬科学）， 学位授与年月日： 令和2年(2020年)3月17日 (98p.)博士（薬科学）城西大
Galectin-2 Has Bactericidal Effects against Helicobacter pylori in a β-galactoside-Dependent Manner
Get PDFHelicobacter pylori is associated with the onset of gastritis, peptic ulcers, and gastric cancer. Galectins are a family of β-galactoside-binding proteins involved in diverse biological phenomena. Galectin-2 (Gal-2), a member of the galectin family, is predominantly expressed in the gastrointestinal tract. Although some galectin family proteins are involved in immunoreaction, the role of Gal-2 against H. pylori infection remains unclear. In this study, the effects of Gal-2 on H. pylori morphology and survival were examined. Gal-2 induced H. pylori aggregation depending on β-galactoside and demonstrated a bactericidal effect. Immunohistochemical staining of the gastric tissue indicated that Gal-2 existed in the gastric mucus, as well as mucosa. These results suggested that Gal-2 plays a role in innate immunity against H. pylori infection in gastric mucus.12p. Article number: 2697, This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Characterization of Nanoparticles Using DSPE-PEG2000 and Soluplus
Get PDFThe aim of this study was to evaluate the characterized hydration method to prepare nanoparticles using Soluplus, a block copolymer with amphipathic properties, and distearoyl phosphatidyl ethanolamine (DSPE)-PEG2000 owing to particle size distribution, zeta potential, particle stability, and transmission electron microscopy (TEM) observed and 31P-NMR spectra. The results showed that, in a suspension of DSPE-PEG2000 and Soluplus at a ratio of 1/1, the prepared microparticles were stable for five days in the dark and at 25 °C. It was also confirmed that the 1/1 suspension of DSPE-PEG2000/Soluplus was stable for five days under the same conditions with the magnesium chloride solution. TEM measurements confirmed the presence of micelle-like particles of 50 to 150 nm in the 1/1 ratio mix of DSPE-PEG2000/Soluplus. 31P-NMR spectral data confirmed that DPSE-PEG2000/Soluplus at mixing ratio of 1/1 has a strong intermolecular with the phosphate group, indicated by the fact that the peak shift and the full width at half maximum were the largest compared with DSPE-PEG2000 with the intermolecular interaction. On the basis of the findings of this study, we conclude that microparticles can be formed using DSPE-PEG2000 and Soluplus via the hydration method, and that the optimum weight ratio of DSPE-PEG2000 to Soluplus is 1/1.Article No.28. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/)
シッソウ ソクド ヘンカ カラ ミタ シッソウ ノウリョク ノ ヒョウカ
Get PDF発行所：公益社団法人 日本学生陸上競技連合 製作：株式会社 陸上競技社 10/29 編集委員会より登録・公開許諾取得済
