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FORMULATION DOSAGE FORM OF TABLET CONTAINING KEPEL LEAF EXTRACT (Stelechocarpus burahol (Blume) Hook.f & Thomson) AS AN ANTIMICROBIAL AGENTS
Get PDFPharmaceutical dosage form that contains herbal materials has been developed in order to make it easy to consume. Tablet is one of pharmaceutical dosage form that generally used. A formulation and antimicrobial test of tablet containing extract of Kepel leaf with different concentration of diluents, binders, and disintegrants has been studied. The evaluation test showed that formulation consist of 25 % of Kepel leaf extract, 64.5 % of avicel PH 102, 2 % of PVP, 7 % of amprotab, 0.5 % of aerosil, and 1 % of talcum are better than the others. The experimental method used in this study was wet granulation. From the result of the mass granulation evaluation, it was obtain that speed flow without vibration was 2.53 second, with vibration was 2.83 second, bulk density was 0.329 g/mL, taped density was 0.376 g/mL and compressibility was 12.65 %. The result of tablet evaluation obtained that the average weight was 498 mg, with the average hardness was 4 kg/cm2 and disintegration time was 2.36 minutes. Antimicrobial test showed that in the concentration of 50 mg/mL, had average inhibitory diameter against S. aureus of 12.96 mm, P. aeruginosa 12.7 mm, and against B. subtilis was 12.53 mm. Whereas, concentration of 62.5 mg/mL had average inhibitory diameter against S. aureus was 13.5 mm, P. aeruginosa was 13.56 mm, and against B. subtilis was 13.43 mm. Both concentrations did not have antimicrobial activity against E.coli
USE OF PLANTS AS TRADITIONAL MEDICINE IN SWAMEDICATION IN PIDIE COMMUNITIES
Get PDFSelf-medication is an act of self-healing using plants as traditional and modern medicine without the intervention of professional medical personnel. Availability of natural materials and affordable prices encourage people to return to using traditional medicines. The purpose of this study is to find out the types of plants used by the community Pidie, plant parts and reasons for using plants as traditional medicine in self-medication. The type of research used is non-experimental with the survey method and PRA (Participatory Rural Appraisal), by interviewing 1280 respondents. Parameters of this study are the types of plants used, plant parts and reasons for using plants as traditional medicine in self-medication. The results showed that there were 38 tribes and 53 types of plants. The most widely used plant parts were leaves (44.3%), the least were roots (0.7%), and the reason for using plants as traditional medicine in self-medication was easily obtained (53.8%)
TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY
Get PDFTreatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are -amilase, -glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy
CULTIVATION CONDITIONS FOR PROTEASE PRODUCTION BY A THERMO-HALOSTABLE BACTERIAL ISOLATE PLS A
Get PDFPolyextremophiles have increasingly been utilised to produce thermostable enzymes with better stability in multiple extreme conditions. This study reports the screening results of four new bacterial isolates (PLS A, PLS 75, PLS 76 and PLS 80), isolated from an under water hot springs, in producing thermo-halostable protease enzyme. Optimum cultivation conditions for the protease production were also studied. Screening of protease-producing isolates was conducted using Thermus solid medium enriched with 3% skim milk and 0.5% casein. The growth of the isolates showing protease activity was monitored by measuring the cell dry weight and protease activity during 24 h cultivation period. The activity was also measured at various cultivation conditions, i.e. temperature, pH and salt concentrations. Amongst the four isolates, only PLS A showed the ability to produce protease. The optimum cultivation conditions for protease production were observed at 65C, pH 7 for 18 h incubation. The activity increased with the addition of 1% NaCl concentration (0.085 Unit/mL). The ability of PLS A isolate to produce thermo-halostable protease was encouraging as they could potentially be used in industries requiring the enzyme with multiple extremes
PURIFICATION OF BIODIESEL USING RICE STRAW AND DIOSCOREA ALATA STARCH AS NATURAL ADSORBENTS
Get PDFJaneng starch (Dioscorea Alata) and rice straws are developed to be used as adsorbents in dry washing method to purify crude biodiesel. In this study, we evaluate the potential of rice straw and janeng starch as natural adsorbents in the purification of biodiesel that replace the role of water in absorbing contaminants from biodiesel. The SEM characterization results show that the starch adsorbent and rice straw has an open and porous surface and is evenly distributed for janeng starch. Both adsorbents, either the janeng starch or rice straw, can be applied for the purification of biodiesel. The quality of biodiesel is influenced by the amount of adsorbents used in biodiesel purification. The effectiveness of the adsorbent is shown by the decrease in free fatty acids, alkali numbers, soap numbers and turbidity levels in biodiesel. The concentration of free fatty acid oil in crude biodiesel before the purification step was 0.769 mg-KOH/g, then decreased to 0.128 mg-KOH/g after the adsorption. This acid value had been very low and met the Indonesian quality national standard for biodiesel spesically 0.50 mg-KOH/g. Either janeng starch or rice straw adsorbent was able to reduce the soap content of potassium oleate to level 53.33 ppm from the initial content of 106.67 ppm. These two natural adsorbents can be the alternative adsorbents in the purification of biodiesel that employs dry washing method
ANTIOXIDANT ACTIVITY OF ETHYL ACETATE EXTRACT OF NUTMEG (Myristica fragrans Houtt) STEM BARK
Get PDFAntioxidant activity test for the extract of ethyl acetate nutmeg stem bark (Myristica fragransHoutt) was carried out using 2,2-diphenyl-1picrylhydrazil (DPPH). The test results of antioxidant activity of ethyl acetate nutmeg stem bark extract with DPPH method at a concentration of 25 ppm, 50 ppm and 100 ppm obtained IC50 value = 68.14 ppm with IC50 value of vitamin C (as positive control) 3.657 ppm. The results of column chromatographic separation of ethyl acetate nutmeg stem bark extract obtained 5 combined fractions namely MFEK 1, MFEK 2, MFEK 3, MFEK 4 and MFEK 5. The test results of the fraction antioxidant activity in a good category were the MFEK 1 fraction. The MFEK 2 fraction to MFEK 5 showed an antioxidant activity lower than compared to the ethyl acetate extract. This shows that the ethyl acetate nutmeg stem bark extract has a better inhibitory activity, because there are several active compounds contained in the extract which can inhibit free radicals, so the IC50 value of the extract is better than the fractions
POPULATION STRUCTURE OF DIPTEROCARPACEAE SPECIES IN KETAMBE RESEARCH STATION, GUNUNG LEUSER NATIONAL PARK, ACEH TENGGARA
Get PDFKetambe Research Station is one of the oldest and most complete stations in the world which has abundant biodiversity. The Dipterocarpaceae is one of the family identified as growing in the forest area of Ketambe Research Station. Ecologically, Dipterocarpaceae has several limiting factors for its growth and distribution and the most determining factors are soil factors and climate. Dipterocarpaceae is also known as nest and source of food for orangutans, namely Shorea spp. Therefore, it is necessary to conduct research that aims to determine the population structure of Dipterocarpaceae species in Ketambe Research Station. The method used Quadrat Sampling Technique. Theplacement of the sampling plot was randomly carried out in 25 plots with an area of 1 ha. The result showed that there were three species of Dipterocarapaceae found in this station i.e., Parashorea lucida, Shorea johorensis and Hopea dryobalanoides. Based on the population structure pyramid, P. lucida will survive and develop in the future S. johorensis and H. dryobalanoides, on the other hand, are estimated to decrease or hardly survived in the future
PSIDIUM GUAJAVA LEAVES COMPOUND AS ANTI-INFLAMMATION: SYSTEMATIC REVIEW
Get PDFPsidium guajava leaves are plants that have been widely used to treat health problems, such as inflammation. Guava leaves are one of the parts used in this plant. People use guava leaves because it can be reached and has minimal side effects. The aim of this study was to identify the content available in guava leaves and their bioactivity as anti-inflammatory. The design of this study uses systematic reviews. Article are taken from electronic databases such as Scopus, Pubmed, ProQuest, and Science Direct. Articles are taken from 2013 to 2019 with the keywords phytochemical OR chemical OR compounds AND psidium guajava leaves AND anti-inflammation. The review results of 3 articles explained that guava leaves contain ingredients that can be useful as anti-inflammatory. Guava leaves provide a great effect or benefit to inflammation
ISOLATION AND ACTIVITY ANTIOXIDANT TEST OF COCOA POD HUSK ETHYL ASETAT EXTRACTS (Theobroma cacao L)
Get PDFIsolation and testing of antioxidant activity with1,1-difenil-2-pikril hidrazil (DPPH) from ethyl acetate extract ofcocoa pod husk(Theobroma cacao L) has been carried out.Theobroma cacaoextract (TCE) showed highly strong antioxidant activity with IC50 = 8,75 ppm and vitamine C = 6,07 ppm as positive control. Isolation of the active components of TCE by column chromatography using silica gel absorbent 60 mesh ASTM (Merck 774) and the eluent n-hexane: ethyl acetate (9:1), obtained 7 fraction combined (TCE 1 to TCE 7). There are 6 combined fractions having the potential as antioxidants, namely TCE 2 to TCE 7 with a range of IC50 (6,46 ppm 91,8 ppm). TCE 2 fraction has a very strong antioxidant activity with IC50 = 6,46 ppm. Separation of TCE 2 fraction on silica column chromatography obtained 4 combined fractions (TCE 2.1 to TCE 2.4). The test results of antioxidant activity showed that TCE 2.4 had very strong activity with IC50 = 42,7 ppm.For the TCE 2.2 fraction, preparative TLC was carried out using eluent n-hexane: ethyl acetate (9.5: 0,5) obtained by TCE 2.2.4 isolate with a melting point of 114-120 C and was a steroid class
WINSTON-BATAN: A SEISMOLOGICAL GROUND-MOTION ANALYSIS CODE
Get PDFA thorough understanding of an earthquake is very important to provide a descriptive knowledge and in the same time as a prescriptive knowledge for the future development. In particular, it is essential for site selection and structural design development of nuclear reactor and other critical facilities. Ground motion acceleration time history is an important raw information to understand the earthquake and specific geological condition of where the data is recorded. This paper presented the development of strong-motion analysis code, called Winston-BATAN, which able to interpret ground motion time history. The analysis scope of the code including the ground motion parameters such as peak ground acceleration, several additional seismic intensity parameters, strong motion duration, its frequency content via Fast Fourier Transformation and response spectra analysis. Being developed based on an open source Python programming language, Winston-BATAN is flexible for exploratory study to exploit the ground motion time history and easily improve to accommodate additional features. This code able to read input from PEER NGA type file or a simple time and acceleration data type of ground motion. Analysis results of Winston-BATAN shows a very good agreement compare to the results from the standard tools Seismosignal 2018 Software, in addition flexibility of this code, in particular, to explore the response spectra from the ground motion time history is demonstrated