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顎顔面領域における炎症モデルラット三叉神経節細胞の遺伝子発現動態 : カルモジュリンキナーゼとK+チャネルの解析
Get PDFapplication/pdfThis study investigated functions of the K^+ channel family K member3 (KCNK3) and Calmodulin kinase II β (CaMK II β) in rat trigeminal ganglion neurons under orofacial inflammation. We investigated gene expression following orofacial inflammation in the rat trigeminal ganglion using complementary DNA microarray. Up-regulation of two molecule genes, KCNK3 and CaMK II β mRNAs were demonstrated. Therefore, we investigated the two molecules showing changes in gene expression, pattern and quantity over a 1-week time course after injection of Complete Freund's Adjuvant (CFA) to the rat upper lip. Trigeminal ganglion neurons, 3 days after CFA injection, expressed the two molecule mRNAs and strong staining was identified ipsilateral to the injection site by in situ hybridization histo-chemistry. Quantity of KCNK3 mRNA participated in the changes during orofacial inflammation. These data suggest that profound mechanisms are involved in the symptom.journal articl
松本歯科大学病院小児歯科における,日本語・ポルトガル語併記問診票の作成について
Get PDFapplication/pdfThe population of Brazilians of Japanese descent has been increasing since 2002. We noticed that many parents can speak Japanese but can not read or write it, because three character types are required (Hiragana, Katakana and Kanji). In order to provide support in dental treatment or dental instruction, we made a Japanese-Portuguese pediatric interview sheet for these parents, asking about general health, lifestyle and health behaviors. Parents were asked to completed this form at the first dental visit. Then the completed questionnaires were evaluated by group discussion. The results suggested that it not only pleased the parents during the dental treatment but also helped dentists obtain more information quickly and the shortened the examination time.journal articl
バイオフィルム感染症としての歯周病発症機序試論 : マクロライド系抗菌薬による歯周病薬物療法
Get PDFapplication/pdfCaries and periodontal disease are two major oral diseases and are the infectious diseases due to dental plaques which are formed by intraoral bacteria. In 1999, Costerton proposed that they are biofilm infectious diseases. The systemic disorders due to biofilm include cystic fibrosis pneumonia and infective endocarditis. Biofilms are bacterial populations which are enclosed by extracellular matrix produced by bacteria per se and which adhere to each other and/or surfaces or interfaces such as medical devices. Importantly, bacteria in biofilm are resistant to antibiotics. Periodontal disease as a biofilm infectious disease is considered as below. Porphyromonas gingivalis is implicated in the initiation and progression or periodontitis. Periodontal disease-associated bacteria such as Porphyromonas gingivalis formed biofilm in periodontal pockets or on the surface of cementum. Planktonic bacteria from biofilm invade into periodontal tissues and lead to inflammation and destruction of tissues directly and indirectly by elicit host defense mechanism. Supragingival dental plaques are easily removed by professional mechanical tooth cleaning (PMTC), while subgingival biofilm and bacteria invading into periodontal tissues are difficult to be removed. Therefore, the development of novel methods for periodontal disease is needed to eliminate these biofilms efficiently. Recently, we examine the effect of azithromycin to in vitro biofilm model, which is made of Streptococcus gordonii and Porphyromonas gingivalis to confirm these clinical findings in vitro. Our results suggest that pharmacotherapy to destroy biofilm using antibiotics such as erythromycin and azithromycin is effective and necessary for the treatment of periodontal disease. In addition, our group demonstrated that systemic administration of azithromycin is clinically effective to the treatment of early-onset (aggressive) periodontitis and shorten the period of initial preparation. These results suggest that pharmacotherapy to destroy biofilm using antibiotics is effective and necessary for the treatment of periodontal disease.journal articl
Influences of metal frame design on the mechanical strength of posterior porcelain fused to metal crown
Get PDFapplication/pdfObjectives: The purpose of this study was to find an ideal shape of the metal frame (coping) in the porcelain fused to metal (PFM) crown. The stress distribution was assessed by the load-to-fracture values and a three-dimensional finite element analysis. Methods: Three kinds of coping designs were tested; Design I: Conventional type as control (traditional frame). Design II: 1.0 mm lower than occlusal surface of coping (butterfly frame). Design III: Straight type (flat frame). The load-to-fracture value consisted of three groups (Design I, II and III) of five samples each. The loading location is selected at the area where mesial and distal of the metal frame will coincide with the projection of the occlussal surface. All samples were loaded to fracture at the rate of 0.1 mm/min using a universal-testing machine. The stress distribution was assessed in a three-dimensional finite element model, which consisted of the abutment tooth, cement, metal coping and porcelain. The loading position is the projection point ofbuccal-lingual transitional part of the frame mesial and distal proximal surface on the occlusal surface towards the median, in which the load is in constant value. Loading direction is vertically downward along tooth axis with a load of 2000 N. Results: The mean load-to-fracture value for each group is as follows: Group A (Design I)=1823.0 N±132.7 (S.D.), Group B (Design II)=1940.4 N±147.4 (S.D.), Group C (Design III)=2333.9 N±180.9 (S.D.). The results of the three-dimensional finite element analysis showed that the maximum tensile stress of 84.5 MPa occurred in Design I. The maximum tensile stress in design II and III were 53.8 MPa and 53.3 MPa, respectively, which were the lower than Design I. Conclusions: The results indicated that the butterfly and flat frame designs will increase metal support on proximal porcelain, thus effectively change the stress distribution within the coping and porcelain, optimizing stress distribution in PFM crown under perpendicular load, and enhance structural strength of porcelain of PFM crown.journal articl
