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Get PDF9784905130062application/pdfEdited by Thomas Heinbockel. : London : IntechOpen, 2019.boo
preface
Get PDF9784905130062application/pdfEdited by Thomas Heinbockel. : London : IntechOpen, 2019.boo
歯周治療の動脈硬化症指標（Cardio Ankle Vascular Index:CAVI）に対する効果
Get PDFapplication/pdfIndependent from hyperlipidemia, hypertension, diabetes mellitus, smoking, a classical risk factor for arteriosclerosis, it has been shown that various types of chronic inflammationmay be involved in the development of arteriosclerosis. As a chronic inflammation, theprevalence rate of periodontal disease is reported to be about 80% at the age of 30 to 50years, and about ₉0% at the age of 60ʼs. In this study, cardio ankle vascular index (CAVI),a vascular function test, was measured as an indicator of arteriosclerosis before and aftertreatment of periodontal disease. As a result, it was revealed that CAVI statistically significantly decreased by treatment of periodontal disease. Further studies are needed in thejournal articl
生体肝移植後患児に対する歯科治療時の全身麻酔5症例の検討
Get PDFapplication/pdfWe report 5 cases of general anesthesia for dental treatment in pediatric patients (2 years 6 months oldto6 years old) with living-related liver transplantation. Every patientswere diagnosed to congenital atresia of the bile duct and had living-related livertransplantation (Table 1). The preoperative examination data were normal and they hadno limitation in daily living. Anesthesia was inducted with thiopental sodium in 3 casesand in another 2 cases sevoflurane was used for the induction of anesthesia. Anesthesia was maintained with inhalation anesthetics in every cases, isoflurane with nitrous oxide 2 cases andsevoflurane with nitrous oxide 3 cases. We performed anesthetic management attentively to maintenance of hepatic blood flow, avoidance of hypoxia, infection due to immunosuppressants and liver dysfunction by anesthetic agents. There were nocomplications in perioperative period and they were discharged on the following day.The metabolic rate of isoflurane and sevoflurane in the body were 0.2 % and 3 % respectively.The metabolic rate of sevoflurane is greater than isoflurane , but trifluoroacetic acid is not produced by sevoflurane which may cause liver dysfunction. Desflurane is metabolized more less than isoflurane and it will be a choice of anesthetic agent for the maintenance of general anesthesia. We used nitrous oxide together with isoflurane or sevoflurane in every cases, because of its extremely low metabolic rate and reduction of the volatile anestheticʼs dosage.journal articl
Temporal change in the occlusal vertical dimension and its involvement in modulation of jaw movement in bite-reduced animals
Get PDFapplication/pdfThe occlusal vertical dimension (OVD) in guinea pigs is maintained by tooth eruption and grinding. It has been reported that the experimentally raised OVD recovers to the innate OVD within a few days in guinea pigs. However, the mechanisms underlying OVD adjustment are not entirely understood. This study thus aimed to clarify whether the experimentally reduced OVD would recover. Bite-reduced guinea pigs were created by applying bilateral intermaxillary elastics for 10 days. Guinea pigs without elastics were used as a control. The OVD after removal of the elastics in the experimental group was compared with that of the control group. Jaw movement during chewing was also compared between the experimental and control groups. After removal of the elastics, the experimentally reduced OVD did not recover fully and a significant difference was observed between the experimental and control groups for up to 25 days during the recording period. The minimum closed position during chewing was
significantly higher in the experimental group than in the control group, whereas the maximum open position was no different between the groups. The present findings indicated that the experimentally reduced OVD could not be fully recovered, suggesting that reduction of the OVD may have limited influence on jaw movement.journal articl
Ectopic transglutaminase 1 and 3 expression accelerating keratinization in oral lichen planus
Get PDFapplication/pdfAbstract Objective: Oral lichen planus (OLP) characterized by interface mucositis frequently shows hyper-keratinization. To clarify mechanisms of excess keratinization, we investigated key molecules for cornified cell envelope (CE). Methods: Involucrin (IVL), loricrin (LOR), transglutaminase 1 (TGase 1) and transglutaminase 3 (TGase 3) were immunohistochemically examined in 20 specimens of OLP; five specimens of buccal mucosa served as controls. Subsequently, the data were statistically analyzed. Results: IVL in OLP was localized in the cell membrane, in contrast to its localization in the cytoplasm in controls. No positive reaction indicative of LOR was noted in any specimens. Although the TGase 1 localization in controls was restricted to the upper three-quarters of the membrane, the localization in OLP was in both membrane and in the cytoplasm of full thickness mucosal layers. The TGase 3 localization pattern was dramatically altered from cytoplasmic to membranous in OLP. Conclusion: Our data suggest that aberrant TGase 1 and TGase 3 localization and distribution are closely related to hyper-keratinization in OLP. This is the first report of ectopic transglutaminase localization in OLP.journal articl