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ヒト歯根膜線維芽細胞におけるメカニカルストレスによるIL-1β, MMP-1(collagenase), collagen type-IのmRNAの発現について
Get PDFapplication/pdfContinuous stretched tension force was applied to human periodontal ligament fibroblasts to determine the effect of this stimulus on the relative expression of IL-1β, matrix metalloproteinase (MMP)-1 and collagen type-ImRNA. The steady-state mRNA level for MMP-1 and collagen type-ImRNA were determined, however IL-1β mRNA was not detected. The results indicate that continuous stretched force in this present study was clinically adapted as orthodontic force but weak to determine the expression of IL-1β mRNA.journal articl
匂いの識別機序
Get PDFapplication/pdfRecent studies in olfaction have made several discoveries concerning odor discrimination, including the following: i) Mammals possess a thousand odorant receptor genes but only a single gene is expressed in each olfactory neuron, ii) Odorant receptors, which are G-pro-tein-coupled receptors, recognize specific structural motifs of odorant molecules, iii) Olfactory neurons, each expressing a specific receptor, project to only two fixed glomeruli in the olfactory bulb. Therefore, each odorant activates a specific combination of receptors which, in turn, produces a specific spatial pattern of activated glomeruli, thus enabling us to discriminate thousands of different odors.journal articl
無脾症候群患者の全身麻酔経験
Get PDFapplication/pdfAsplenia syndrome is a rare congenital abnormality with multiple organ malposition and various cardio-vascular deformity. We experienced a case of Asplenia syndrome with endo-cardial cushion defect, double outlet right ventricle and total anomalous pulmonary venous drainage. The patient was a 4-year-old female who required general anesthesia for dental treatment. Diagnosis of Asplenia was made at her early neonate and Fontan operation was performed at 2 years and 10 months old. Pulseoximeter showed 89 to 90% of oxihemoglobin under room air respiration, but no clubbed finger nor cyanosis were appeared as a present state. After the establishment of a venous route, anesthesia was induced with flunitrazepam (0.4 mg) and fentanyl (75 μg), and orotracheal intubation was done after facilitated with vecuronium bromide (1.6 mg). Anesthesia was maintained with the continuous infusion of fentanyl (3μg/kg/hr) and intermitted supplementation with flunitrazepam and vecu-ronium bromide. The patient was ventilated with oxygen (1.5l/min) and air (4.5l/min). Dental caries treatment for 14 teeth (11 composite resin filling and 3 prosthese after pulpectomy) was performed. The course of anesthesia during 4 hours and 10 minutes was uneventful, and also the post operative course was satisfied with sedation.journal articl
