Jurnal Mahasiswa PSPD FK Universitas Tanjungpura
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UJI EFEK HIPOGLIKEMIK EKSTRAK ETANOL DAUN LIDAH BUAYA (Aloe vera L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN
Get PDFBackground: Diabetes mellitus is a group of metabolic diseases characterized byhyperglycemia. Gel from lidah buaya leaves (Aloe vera L.) contain secondarymetabolites compound which reduce blood glucose level. Objective: The aim ofthis study is to investigate the hypoglycemic effect and find effective dose ofethanolic extract from lidah buaya leaves on male wistar rats after alloxaninduction compared with metformin as positive control. Method: The researchwas a randomized pre-test post-test controlled group design experiment. Thirtywistar rats was randomly divided into 5 experimental group, negative control(CMC 0,5%), positive control (metformin), dose I (250 mg/k gBW), dose II (500mg/kgBW, and dose III (1000 mg/kgBW). All groups were induced with alloxan toa glucose level approximately more than 200 mg/dl. Treatments wereadministered for 7 days. The data were analyzed by One-way Anova testcontinued with LSD Post Hoc test. Result: From the phytochemical screeningresult, lidah buaya leaves ethanolic extract contain flavonoid, alkaloid, saponin,glycoside. Statistical analysis showed significant difference between averageglucose level from control group (negative and positive) against dose I group,dose II group and dose III group (p<0,05) at day-8. Significant differencebetween dose I group and dose II group, dose I group and dose III group, dose IIgroup and dose III group, is not found Conclusion: Ethanolic extract from lidahbuaya leaves has hypoglycemic effect better than metformin on white male wistarrats after alloxan induction with effective dose at 250 mg/kgBW.Key Words: Aloe vera L., blood glucose level, ethanolic extrct from lidah buayaleaves, alloxan induction1)Medical School, Faculty of Medicine, Universitas Tanjungpura Pontianak,Kalimantan Barat2)Department of Pharmacology, Medical School, Faculty of Medicine,Universitas Tanjungpura Pontianak, Kalimantan Barat3)Departement of Community Health, Family Health and Public Health,Medical School, Faculty of Medicine, Universitas Tanjungpura Pontianak,Kalimantan Bara
HUBUNGAN ANTARA MEROKOK DENGAN IMT (INDEKS MASSA TUBUH) MAHASISWA S1 UNIVERSITAS TANJUNGPURA, KALIMANTAN BARAT
Get PDFLatar Belakang: Survei secara nasional menemukan hampir 2/3penduduk dari kelompok umur produktif adalah perokok. Penelitian SunHa Jee et al, mendapat hasil bahwa IMT perokok di Jepang lebih rendahdibandingkan bukan perokok. Hal ini juga didukung oleh penelitian PragtiChhabra dan Sunil K. Chhabra, yang mendapatkan hasil bahwa perokok diIndia mempunyai IMT kategori dibawah normal 30% lebih banyakdibandingkan bukan perokok dan dari 99 studi didapatkan hasil pria yangsehari-harinya merokok mempunyai IMT rendah 3% lebih banyakdaripada pria bukan perokok. Tujuan: Penelitian ini bertujuan untukmengetahui hubungan antara merokok dengan IMT mahasiswa S1Universitas Tanjungpura. Metodologi: Desain penelitian analitik denganpendekatan potong lintang. Jumlah sampel sebanyak 242 orang, terdiridari 126 current smoker dan 116 never smoker. Hasil: Current smokermempunyai kecenderungan 1,93 kali lebih tinggi untuk memiliki IMT <18,5dibandingkan never smoker. Kesimpulan: Merokok memiliki hubunganyang bermakna dengan IMT. Kata Kunci: merokok, IMT, current smoker, never smoke
EFFECT OF OINTMENT FROM COMBINED Centella asiatica (L.) Urban AND Coleus amboinicus EXTRACTS ON SKIN WOUND TISSUE REPAIR IN DIABETIC RATS
Get PDFBackground: A single Centella asiatica L. Urban (CALU) extract stimulated cellular proliferation in granulation tissue, while a single Coleus amboinicus L.(CAL) extract acted as antiseptic agent. Diabetic wound closure is sensitivelydifficult to be done because proliferation is likely inhibited by antisepticalteration resulted as infectious wound. Both extracts may give synergy incombination into ointment. Objective: to investigate the effect of combinedextractsointmentonangiogenesis,inflammatorycellsandmicroscopicwounddiameter.Methods:posttestonlygroupdesignwasexperimentallyconducted,sixtyratswererandomly divided into 5 groups; each group was treated withdifferent ointment constituent: single 1,5% CALU extract; single 5% CALextract; both extracts (1,5%CALU+ 5%CAL); placebo and Sanoskin MelladermPlus® (SMP). Diabetic rat’s skin was excised and treated with hydrocarbonbasedointment.Assessmentonangiogenesis,inflammatorycellsandwounddiameterwereobservedhistopathologicallyonday3,7and14aftertreatment.Thedata were analyzed by one-way ANOVA and LSD. Results: combinedextractsointmenteffectwassignificantlydifferent(p0,05) compared to SMP®in term of wound diameter reduction. Conclusion: Combined-extractsointment is better than either single extract, placebo or SMP® in improvingangiogenesis and reducing number of inflammatory cells, but not better thanSMP® in reducing wound diameter.Keywords: combined-extracts, single extract, angiogenesis, inflammatory cells, wound diameter.1. Medical School, Faculty of Medicine, Universitas Tanjungpura, Pontianak 2. Departement of Pathology Anatomy, Faculty of Medicine, UniversitasTanjungpura, Pontianak 3. Departement of Physiology, Faculty of Medicine, Universitas Tanjungpura,Pontiana
HUBUNGAN KONDISI FISIK RUMAH DAN LINGKUNGAN SEKITAR RUMAH DENGAN KEJADIAN MALARIA DI DESA TANJUNG SATAI KECAMATAN PULAU MAYA KARIMATA KABUPATEN KAYONG UTARA TAHUN 2010
Get PDFLatar Belakang: Malaria merupakan salah satu penyakit menularyang menjadi masalah kesehatan masyarakat di dunia termasuk diIndonesia. Kecamatan Pulau Maya Karimata adalah salah satu dari6 kecamatan yang ada di Kabupaten Kayong Utara yangmenduduki peringkat pertama untuk kasus malaria positif padatahun 2010. Kejadian malaria dipengaruhi oleh kondisi fisik rumahpenduduk dan lingkungan sekitar rumah penduduk. Tujuan:Mengetahui hubungan antara kondisi fisik rumah dan lingkungansekitar rumah dengan kejadian malaria di Desa Tanjung SataiKecamatan Pulau Maya Karimata Kabupaten Kayong Utara padaTahun 2010. Metodologi: Penelitian ini merupakan survei analitikdengan rancangan case control. Kasus adalah penderita malariapositif pada tahun 2010 dan kontrol adalah penduduk yang tidakpernah menderita malaria. Analisis dilakukan secara bivariatdengan menggunakan uji Chi-Square dan analisis multivariatdengan menggunakan regresi logistik. Hasil Penelitian: Jumlahsampel penelitian adalah 132 responden dengan 66 respondenkasus dan 66 responden. Variabel bebas yang memiliki hubungansignifikan dengan kejadian malaria (p=<0,05) dan merupakan faktorrisiko kejadian malaria adalah kerapatan dinding rumah,keberadaan plafon rumah, genangan air, semak-semak, dankandang ternak. Sedangkan keberadaan kawat kassa tidakmemiliki hubungan yang signifikan dengan kejadian malaria (p=1).Seseorang yang mempunyai keempat faktor risiko tersebut memilikikemungkinan terkena malaria sebesar 99% lebih besar daripadaseseorang yang tidak memiliki faktor risiko. Kesimpulan: Variabelyang merupakan faktor risiko kejadian malaria adalah kerapatandinding, keberadaan semak-semak, genangan air, dan kandangternak. Sehingga disarankan untuk meningkatkan kegiatanpembersihan lingkungan sehingga tidak menjadi sarang nyamuk.Kata Kunci: Kondisi Fisik Rumah, Lingkungan Sekitar Rumah,Malari
EFEKTIVITAS DOSIS HEMODIALISIS PADA PASIEN PENYAKIT GINJAL KRONIK DI RSU DOKTER SOEDARSO PONTIANAK PERIODE AGUSTUS 2013 – OKTOBER 2013
Get PDFLatar Belakang: Kidney Disease Outcomes Quality Initiative (KDOQI)pada tahun 2006 menetapkan nilai dosis minimum hemodialisis (spKt/V)adalah >1,2. Nilai spKt/V yang tidak tercapai merupakan penyebab utamatingginya risiko mortalitas. Tujuan: Mengetahui pencapaian nilai spKt/Vtiap bulan di Rumah Sakit Umum (RSU) Dokter Soedarso Pontianak.Metode: Penelitian analitik dengan desain cross-sectional. Sampeldiambil dari ruang hemodialisa RSU Dokter Soedarso Pontianak denganjumlah sebanyak 30 orang, Instrumen yang digunakan adalah data rekammedis. Data dianalisis dengan uji repeated ANOVA. Hasil: Usia pasienterbanyak 40-44 (23,3%). Distribusi konsentrasi urea darah pra dan pascahemodialisis terbanyak >110-190mg/dL (63,3%; 60%; 50%) dan >2559mg/dL(46,7%; 50%; 66,7%). Distribusi selisih berat badan terbanyak140/90mmHg (63,3%; 70%;73,3,%) dan >140/90mmHg (63,3%; 60%; 56,6,%), untuk diabetes>130/80mmHg (16,7%; 16,7%; 16,7%) dan >130/80mmHg (16,7%;16,7%; dan 16,7%). Nilai rata-rata spKt/V 1,40+0,46; 1,46+0,51; dan1,56+0,57 (66,7%; 63,3%; 70%), efektivitas kenaikan nilai spKt/V denganlama pemberian terapi selama tiga bulan dengan uji repeated ANOVAdidapatkan nilai p=0,419. Kesimpulan: Pemberian terapi hemodialisispada bulan Agustus–Oktober 2013 telah efektif
HUBUNGAN ANTARA KARAKTERISTIK IBU DAN PEMBERIAN ASI EKSKLUSIF
Get PDFBackground: World Health Organization recommended exclusive breastfeeding for six months. Exclusive breastfeeding rate was relativelylow in some regions. Factors influencing exclusive breastfeeding need tobe identified. This study aims to estimate the prevalence and the mother’scharacteristic influencing exclusive breastfeeding.Method: This study was a retrospective cross-sectional study. The studywas performed in a population of mothers who have baby aged 6-24months in Puskesmas Sungai Raya Dalam. A total of 104 samples wereobtained by questionnaire and interview.Result: In this study, the prevalence of infants who ever breastfed was95%, the infants who had an exclusive breastfed 2%, and 79% wasbreastfed more than six months old. Prevalence of giving complementaryfood before infant aged six months old was 98% and giving prelacteal foodwas 50%. Most of the infants were given complementary food at aged 0-7days old (72%). Most of mothers were aged 26-35 years old (48%),unemployed (90%) and had a low educational background (57%),prosperous lives (81%) and primiparous (52%). Mother’s characteristics(mother’s age, work hours, education level, prosperity and parity) were notassociated with exclusive breastfeeding. Conclusion: Mother’s characteristics are not associated with exclusivebreastfeeding. Exclusive breastfeeding rate is still very low due to the highpractices of giving complementary food before infant aged six months oldand prelacteal food.Keywords : Exclusive breastfeeding, mother’s characteristic 1) Medical school, Faculty of Medicine, Universitas Tanjungpura, Pontianak, West Kalimantan2) Department of Child Health, Faculty of Medicine, Universitas Tanjungpura, Pontianak, West Kalimantan3) Department of Physiology, Faculty of Medicine, Universitas Tanjungpura, Pontianak, West Kalimanta
Perbandingan Kejadian Inflamasi dan Rekurensi antara Benang Nylon dan Benang Vicryl Pasca Operasi Pterigium dengan Teknik Limbal-Conjunctival Autograft di RSUD dr. Soedarso Pontianak
Get PDFBackground: Inflammation and recurrency are the most common complications after pterygium surgery. Recently, various methodes have been tried to reduce the incidence of both complications. Objective: The objective of this study was to compare the incidence of inflammation and reccurency after pterygium surgery with nylon and vicryl suture using limbal-conjunctival autograft technique in RSUD dr. Soedarso Pontianak. Methods: This was an observational analytic study with cross sectional design. Data were obtained using medical records from patients operated from January 2011 until December 2012 by consecutive sampling method. Minimal sample estimation was 30 subject (CI=90%). Data were analyzed by Chi Square test, Fisher test is used as the alternative test. Result: The incidence of inflammation was higher in the vicryl group (43%) than nylon group (23%). Chi Square test: p=0,024. The incidence of recurrency was higher in the vicryl group (9%) than nylon group (3%). Fisher test: p=0,603. Conclusion: There was a significant comparison between type of suture with the incidence of post-operative inflammation. There was no comparison between type of suture with the incidence of recurrency. Keywords : Nylon, Vicryl, Pterygium Surgery, Limbal-conjunctival autograft, Post Surgical Inflammation, Pterygium Recurrency. 1) Medical school, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan. 2) Departement of ophtalmology disease, Regional General Hospital dr. Soedarso, Pontianak, West Kalimantan. 3) Department of physiology, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan
PERBEDAAN PERTUMBUHAN BAYI USIA 3-6 BULAN YANG DIBERI ASI EKSKLUSIF DAN YANG TIDAK DIBERI ASI EKSKLUSIF DI PUSKESMAS GANG SEHAT KECAMATAN PONTIANAK SELATAN
Get PDFLatar Belakang: Bayi usia 0-6 bulan dapat tumbuh dan berkembangsecara optimal dengan hanya mengandalkan asupan gizi Air Susu Ibu (ASI). Pemberian susu formula dan makanan pendamping ASI (MP-ASI)pada bayi berumur kurang dari 6 bulan kurang baik bagi pertumbuhan bayi. Tujuan: Menganalisis perbedaan pertumbuhan antara bayi usia 3-6 bulanyang diberi ASI eksklusif dan yang tidak diberi ASI eksklusif. Metode: Penelitian ini merupakan studi analitik dengan pendekatan cross sectionalyang dilakukan terhadap 44 bayi usia ?6 bulan di poli Gizi Puskesmas Gang Sehat Pontianak Selatan. Data diperoleh melalui kuesioner dan KartuMenuju Sehat (KMS) kemudian dianalisis menggunakan uji t tidak berpasangan. Hasil: Rerata kenaikan berat badan per bulan bayi yangdiberi ASI eksklusif 0,44 0,03 kg sedangkan yang tidak diberi ASI eksklusif 0,62 0,03 kg dengan selisih rerata 0,18 kg. Hasil analisis statistikmenunjukkan terdapat perbedaan rerata bermakna dengan p0,05). Kesimpulan: Terdapat perbedaan pertumbuhan berat badan antara bayiusia 3-6 bulan yang diberi ASI eksklusif dengan yang tidak diberi ASI eksklusif, tetapi tidak terdapat perbedaan pertumbuhan panjang badanantara keduanya. Kata kunci: ASI eksklusif, pertumbuha
UJI EFEK EKSTRAK N-HEKSAN DAUN BAWANG KUCAI (Allium Tuberosum Rottl . Ex Spreng) TERHADAP KADAR KOLESTEROL DALAM LDL (Low Density Lipoprotein) PADA TIKUS PUTIH (Rattus Norvegicus) JANTAN GALUR WISTAR
Get PDFBackground: Garlic chives/kucai ( Allium TuberosumRottl ExSpreng) contain Allicin that has an inhibitory effect for HMG-KOAreductase enzyme resulting in decreased cholesterol level.Objective: the research would investigate the effect of reductionLDL (Low Density Lipoprotein) and effective dose of garlic chivessn-hexane extract in male wistar rate compared with pravastatin asposstive control. Method: the research was a time seriesexperiment. Twenty five wistar rat was randomly divided into 5experimental group, negative control ( CMC 1% ), positive control pravastatin ), dose I (0.0225 g/200 gBW),dose II (0,045 g/200gWB), and dose III (0,09 g/200 gWB that was induced by highcholesterol diet for 14 days. Data is analyzed with One-Way Anovatest continued with LSD Post Hoc test. Results: phytochemical testresult shows garlic chives n-hexane extract containsteroid/terpenoid secondary metabolite. Statistical analysis showedsignificance difference between average cholesterol level fromcontrol group ( negative and positive ) against dose I group ,II anddose III group (p<0,05) at day-42. The effective dose was 0,045g/200 gWB. Conclusion: n-hexane extract of garlic chives has LDLreduction effect on albino male wistar rat with effective dose at0,045 g/200 gWB which shows the same activity with pravastatincontrol group. Keyword: Allium tuberosum Rottl ex Spreng, n-hexane extract of garlic chives, high cholesterol diet, total cholesterol level loweringeffec
HUBUNGAN ANTARA RIWAYAT PENGGUNAAN CEFADROXIL DENGAN KEJADIAN STEVEN-JOHNSON SYNDROME DI RSU Dr.SOEDARSO PONTIANAK PERIODE 2007 - 2010
Get PDFBackground: Steven-Johnson syndrome is a hypersensitivity disease was mediated by immune complexes caused by some drugs or infections. The incidence of Stevens-Johnson syndrome induced by drug allergy is increasing in Indonesia. Cefadroxil is a high risk Stevens-Johnson syndrome cause.Objective: To determine association between history of cefadroxil with the occurrence of Steven-Johnson syndrome at RSU dr.Soedarso Pontianak in period 2007- 2010.Method: This is an analytic observational with retrospective study. Ninety five samples were participated. Data was processed by chi square test.Result: Based on the history of the use of cefadroxil, 14 people were diagnosed with Stevens-Johnson Syndrome and 18 people were diagnosed with other forms of Drug Eruption, while based on a history of drug use other types, 26 people were diagnosed with Stevens-Johnson Syndrome and 37 people were diagnosed Drug Eruption. The results show the value of p = 0.817, PR = 1,060, 95% confidence interval = 0.649 to 1.732.Conclusion: There is no significant association between history of consuming cefadroxil and Steven-Johnson syndrome occurrence.Keywords: Steven-Johnson syndrome cefadroxil RSU dr.Soedarso 2007-201