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ウエルドナットと締め込みスタッドによる疲労き裂の簡易進展防止手法の検討
Get PDFThe recent increase in the amount of traffic has led to a substantial increase in the number of fatigue cracks in steel bridges. The stop-hole method is the most commonly used method to repair fatigue cracks. However, it may decrease the strength of the bridge owing to holes drilled in the member. In this study, we proposed a method for delaying the propagation of cracks by weld nuts and tightened studs welded to crack tips using a stud welder. The effect of these method ware examined by four-point bending fatigue tests using pre-cracked bead-on plate specimen.departmental bulletin pape
Die aktuelle Diskussion über ne bis in idem in Deutschland ―Anmerkung des BVerfG, Urteil vom 31. Oktober 2023―
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An Estimation of the Number of Friends and Acquaintances using Event Subpopulation and a Revision of the Estimation Model: By the Number of those Who were Infected with COVID-19 and Who Died from The Great East Japan Earthquake
Get PDFThe size of personal networks, i.e., the number of friends and acquaintances, is estimated using the event subpopulation of those who were infected with COVID-19 or who died from The Great East Japan Earthquake. However, the estimated size widely differed by how we set the population. So, the model was modified using the biased network model, where the inbreeding bias parameter moves between 0 and 1. The estimated size of personal networks tends to be larger when the bias is low and smaller when the bias is high. Although the estimates became more plausible, the exact value of the inbreeding parameter is still not well-determined.専攻: 数理・軽量社会学、社会ネットワーク分析departmental bulletin pape
Chat GPT (Generative AI) and Its Impact on Society and Human Rights
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Inter-American Convention Against All Forms of Discrimination and Intolerance
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Antidiabetic agent in Japan
Get PDF糖尿病を発症した時点では，すでに膵β細胞機能は約50％にまで低下しているという報告もあり，また慢性的な高血糖がもたらす糖毒性に対してβ細胞は特に脆弱であり，糖毒性はβ細胞の量的・質的な低下を引き起こし，さらに血糖が上昇するという病態としての悪循環が形成される．近年多くの臨床研究により糖尿病発症早期に適切な治療介入を行うことで，糖尿病合併症の発症および進展を軽減できることが示されている．従来，糖尿病治療薬はその作用機序から低血糖を生じやすい薬剤が大半を占めていたが，2000年前後から低血糖リスクの少ない薬剤が次々と上市され，またICTの進歩に伴いインスリンポンプ治療も革新的な発展を遂げてきている．まさに，昨今の糖尿病治療分野においてはパラダイムシフトが起きている．本稿では，研修医の先生を主な対象として，2024年１月時点において日本で健康保険適応となっている経口血糖降下薬を中心に概説する．研修医のための教育講座departmental bulletin pape
