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Dalla funzione sociale all'etica ed alla responsabilità sociale dell'impresa. Il pensiero di Sergio Sciarelli
No full textUn'analisi dell'evoluzione del pensiero sui temi dell'etica e della responsabilità sociale d'impres
BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma article
No full textBRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response. In this study, we found that the reduced expression of BAP1 pro6motes the survival of neuroblastoma cells, and restoring the levels of BAP1 in these cells facilitated a delay in S and G2/M phase of the cell cycle, as well as cell apoptosis. The mechanism that BAP1 induces cell death is mediated via an interaction with 14-3-3 protein. The association between BAP1 and 14-3-3 protein releases the apoptotic inducer protein Bax from 14-3-3 and promotes cell death through the intrinsic apoptosis pathway. Xenograft studies confirmed that the expression of BAP1 reduces tumor growth and progression in vivo by lowering the levels of pro-survival factors such as Bcl-2, which in turn diminish the survival potential of the tumor cells. Patient data analyses confirmed the finding that the high-BAP1 mRNA expression correlates with a better clinical outcome. In summary, our study uncovers a new mechanism for BAP1 in the regulation of cell apoptosis in neuroblastoma cells
About Nuclear Italy: an International History of Italian Nuclear Policies during the Cold War
No full textNeutrophil extracellular traps as an adhesion substrate for different tumor cells expressing RGD-binding integrins.
No full textNeutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play a relevant role in thrombus formation and metastatic dissemination of cancer cells. Here we screened different cancer cell lines endogenously expressing a variety of integrins for their ability to bind to NETs. To this end, we used NETs isolated from neutrophil-like cells as a substrate for adhesion assays of HT1080, U-87 MG, H1975, DU 145, PC-3 and A-431 cells. Levels of α5, αIIb, αv, β1, β3 and β5 chains were determined by western blot analysis in all cell lines and levels of whole integrins on the plasma membrane were assessed by fluorescence-activated cell sorting (FACS) analysis. We found that high levels of α5β1, αvβ3 and αvβ5 enhance cell adhesion to NETs, whereas low expression of α5β1 prevents cell attachment to NETs. Excess of cyclic RGD peptide inhibited cell adhesion to NETs by competing with fibronectin within NETs. The maximal reduction of such adhesion was similar to that obtained by DNase 1 treatment causing DNA degradation. Our findings indicate that NETs from neutrophil-like cells may be used as a substrate for large screening of the adhesion properties of cancer cells expressing a variety of RGD-binding integrins
Aldo Moro e la questione meridionale
No full textIl saggio analizza la centralità che la questione meridionale ebbe nell’azione
politica e nel pensiero di Aldo Moro. Si evidenzia come tale problematica
fosse in linea con l’impegno sociale e civile nei confronti delle
masse popolari e con la concezione di autonomismo locale della Democrazia
cristiana, nonché che la stessa doveva essere inquadrata nell’ottica dell’integrazione
europea in fieri. Inoltre, oggetto di analisi è il ruolo dello Stato
nel pensiero di Moro: esso doveva assumere il ruolo di propulsore dell’attività
economica, fungendo da traino dell’iniziativa privata
Le unioni civili fra Giudice e Legislatore
No full textThe essay traces the stages of the dialogue between judges and legislator that led to the approval of the law n. 76/2016. In particular, the essay emphasizes the relevance of the role of the ordinary judges who, understanding the importance of the right to a steady union for homosexual couples, have then appointed the Constitutional Court to solve this delicate problem. With two decisive rulings, the Court has laid out the way for the intervention of the legislator
Synchronization of networks of piecewise-smooth systems
No full textWe study convergence in networks of piecewise-smooth (PWS) systems that commonly arise in applications to model dynamical systems whose evolution is affected by macroscopic events such as switches and impacts. Existing approaches were typically oriented toward guaranteeing global bounded synchronizability, local stability of the synchronization manifold, or achieving synchronization by exerting a control action on each node. Here we start by generalizing existing results on QUAD systems to the case of PWS systems, accounting for a large variety of nonlinear coupling laws. Then, we propose that a discontinuous coupling can be used to guarantee global synchronizability of a network of N PWS agents under mild assumptions on the individual dynamics. We provide extensive numerical simulations to gain insights on larger networks
A petrological insight on the juvenile products of the last 1000 years of explosive activity at La Soufrière Volcano, St. Vincent (Lesser Antilles)
No full textUnderstanding the recent history of active volcanoes is crucial to assessing the volcanic hazard for the
surrounding areas. In this perspective, a detailed petrochemical characterization of the emplaced products
can give useful insights on the ongoing magma processes driving the volcanic system to its current state.
This is particularly true for the La Soufrière Volcano of St. Vincent, the most active subaerial volcano in the
Lesser Antilles in historical times, with the last eruption of 1979 reaching a VEI of 3 and leading to the
evacuation of ~20000 people. However, most of the current knowledges on magma processes at La Soufrière
relies on petrological studies performed on the products of the oldest prehistorical activity, covering the
~600-1.3 ka age interval.
We here present a petrological characterization (whole-rock, mineral and glass phases geochemistry) for the
juvenile products of explosive events occurred during the last 1000 years at La Soufrière: the historical
eruptions of 1902/03 and 1718/1812 and the prehistorical eruptions of 1580, 1440 and an older undated
event. The products of the prehistorical eruptions are represented by basaltic andesite scoria clasts displaying
a quite homogeneous composition in terms of both petrography (with labradorite-bytownite plagioclase, Mg-
and Al-poor augite clinopyroxene, Mg-poor orthopyroxene and Ti- magnetite) and whole-rock geochemistry
(e.g. SiO 2 = 55.1-56.7 wt.%, MgO = 3.13-3.73 wt.%, wt.%, Cr = 20-30 ppm, Zr = 82-96 ppm). Products of
the historical eruptions are generally similar but also include less evolved lithotypes, with 1902/03 scoria
clasts reaching basaltic compositions with labradorite-anorthite plagioclase, Mg- and Al-rich diopside
clinopyroxene and Mg-olivine, SiO 2 = 50.6-51.2 wt.%, MgO = 7.64-7.91 wt.%, wt.%, Cr = 270-300 ppm, Zr
= 60-65 ppm. This speaks in favour of a recent magma renewal which possibly triggered a phase of relatively
intense volcanic activity (~80-100 year periodicity), culminating with destructive events causing ~1500
deaths
