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On the new Geography of a multi-cone world
No full textWe build a new economic geography model incorporating differences in productivity among sectors and countries, thus allowing for comparative advantage. We study the role that market size, absolute advantage, and comparative advantage have on the trade patterns and the long‐run spatial distribution of economic activity in a world with multicones of specialization. We briefly mention the possibility of long‐term fluctuations in the spatial distribution of industry by relying on a discrete‐time framework
Evaluation of collapse displacements in dry-jointed masonry structures subjected to settlements: Experimental tests and rigid block modelling
No full textCDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors.
No full textCyclin-dependent kinases (CDK) 4/6 inhibitors, namely abemaciclib, palbociclib, and ribociclib, interfere with cell cycle progression, induce cell senescence and might promote cancer cell disruption by a cytotoxic T cells-mediated effect. Phase III randomized clinical trials have proven that CDK4/6 inhibitors (CDK4/6i) in combination with several endocrine agents improve treatment efficacy over endocrine agents alone for hormone receptor positive (HR+) HER2 negative (HER2-) metastatic breast cancer (MBC). Based on such results, these combinations have been approved for clinical use. Preclinical studies in cell cultures and mouse models proved that CDK4/6i are active against a broad spectrum of solid tumors other than breast cancer, including liposarcoma, rhabdomyosarcoma, non-small cell lung cancer, glioblastoma multiforme, esophageal cancer, and melanoma. The role of CDK4/6i in monotherapy in several solid tumors is currently under evaluation in phase I, II, and III trials. Nowadays, abemaciclib is the only of the three inhibitors that has received approval as single agent therapy for pretreated HR+ HER2- MBC. Here we review biological, preclinical and clinical data on the role of CDK4/6 inhibitors as single agents in advanced solid tumors
Impact of Lactobacillus curvatus 54M16 on microbiota composition and growth of Listeria monocytogenes in fermented sausages
No full textLactobacillus curvatus 54M16 produced bacteriocins sak X, sak Tα, sak Tβ and sak P. The aim of this study was to investigate the anti-listerial activity of the bacteriocins-producing strain against Listeria monocytogenes in vitro co-culture experiments and during the manufacture of fermented sausages. In MRS broth, Lb. curvatus 54M16 was able to inhibit L. monocytogenes to undetectable levels after 48 h at 20 °C or 5 days at 15 °C. Anti-listerial activity was lower during the production of fermented sausages with pathogen inoculation at levels of approximately 4 Log CFU g−1. However, total inhibition of L. monocytogenes native to the raw ingredients was achieved over the course of the fermentation. Moreover, 16S rRNA-based analysis revealed the ability of Lb. curvatus 54M16 to dominate and affect the bacterial ecosystem, whereas spoilage-associated bacterial genera, such as Brochothrix, Psychrobacter, Pseudomonas and some Enterobacteriaceae, were found until the end of ripening in sausages without Lb. curvatus 54M16. The use of the bacteriocins-producing Lb. curvatus 54M16 in fermented sausages could be an important contribution to product safety, provided that eco-physiological factors and other preservation methods are maintained at levels required for the inhibition of pathogens in controlled conditions
Tracking plumbing system dynamics at the Campi Flegrei caldera, Italy: High-resolution trace element mapping of the Astroni crystal cargo
No full textThe Campi Flegrei caldera (southern Italy) is one of the most hazardous volcanic systems on Earth, having produced >60 eruptions in the past 15 ka. The caldera remains active and its potential for future eruptions is high, posing a danger to the dense population living nearby. Despite this, our understanding of pre-eruptive processes and the architecture of the sub-volcanic system are poorly constrained. Here, we combine established petrological techniques, geothermobarometric evaluation, and high-resolution trace element crystal mapping, to present a multifaceted, coherent reconstruction of the complex pre-eruptive dynamics and eruption timescales of Astroni volcano located in the eastern sector of Campi Flegrei caldera. The Astroni volcano is an important case study for investigating plumbing system processes and dynamics at Campi Flegrei caldera because it produced the most recent (ca. 4 ka ago) Plinian eruption within the caldera (Astroni 6); current long-term forecasting studies postulate that a similar sized event in this location is a probable future scenario.
Geothermobarometric results indicate interaction between an evolved, shallow magma chamber, and a less evolved, deeper pocket of magma, in agreement with previous studies focused on the Astroni 6 eruption products. In addition, a range of textural and trace element zoning patterns point to a complex evolution of both magmas prior to their subsequent interaction. High-resolution trace element crystal maps reveal discrete zonations in compatible elements. These zonations, combined with knowledge of K-feldspar growth rates, highlight a recharge event in the shallow plumbing system a few hours to days before the Astroni 6 eruption
Comitato Scientifico Convegno La declinazione del principio di proporzionalità in ambito bancario: problemi e prospettive
No full textI profondi cambiamenti che interessano il sistema della supervisione bancaria pongono numerosi interrogativi in tema di adeguatezza dei processi di controllo istituzionale. Il concetto di adeguatezza patrimoniale richiede una corrispondente adeguatezza regolamentare, al fine di non ridurre entro una "taglia unica" il processo di controllo e, pertanto, depauperarne il potenziale di efficacia. Ne discutono esponenti delle autorità di vigilanza, studiosi, professionisti ed operatori del sistema in una giornata dedicata ad un tema che assume uno specifico rilievo per gli attori di dimensione "meno significativa" ma di valore "non meno significativo".
L'incontro organizzato, che costituisce una rilevante occasione di riflessione a più voci sulla implementazione di un principio che richiede sempre maggiore attenzione, è organizzato dal DEMI, Dipartimento di Economia, Management, Istituzioni in collaborazione con l'Associazione Italiana Financial Industry Risk Managers si terrà il 12 ottobre 2018 presso il Centro Congressi di via Partenope 36 dalle 9.30 alle 17.00
Autoritratti e ritratti di un poeta d’amore del Quattrocento: Giovanni Gioviano Pontano
No full textIl saggio cerca di ricostruire il processo di costruzione e di acquisizione di un’identità poetica da parte del Maestro
riconosciuto dell’Umanesimo aragonese a Napoli, Giovanni Gioviano Pontano. Si tratta di un processo di
costruzione identitaria che prende le mosse dall’orgogliosa rivendicazione delle origini umbre, che accomunavano il
Pontano a Properzio, e che passa poi all’acquisizione di un’identità partenopea, che accomunava invece l’umanista a
quello che egli considerava il più grande poeta dell’antichità, Virgilio. Il codice simbolico ed allusivo con cui il Pontano
amò definire la sua identità, in rapporto a Napoli e al mito di Parthenope-Sirena, ebbe un significativo Fortleben
tra gli intellettuali della sua Accademia a Napoli e fuori del Regno, ma anche tra coloro che a vari livelli lo amarono
e lo celebrarono come poeta, filosofo, scienziato, dichiarandosi suoi eredi o semplicemente epigoni. Il saggio si presenta
allora come un primo tentativo di sintesi in relazione, anzitutto, alla produzione poetica ed erotico-amorosa del
Pontano
Docendo Discimus: Three generations share their knowledge and passion for BIOLOGY
No full textStudenti liceali e tre generazioni di biologi fanno squadra per proporre e coinvolgere il pubblico di tutte le fasce di età in interessanti attività. Muniti di carta, matita, riga e ...Fantasia per costruire origami di DNA 3D anche personalizzati. Sono proposte diverse attività nel corso della giornata progettate per i visitatori di tutte le fasce d’età; il tutto “condito” con semplici esperimenti e giochi per scoprire e divertirsi coi numeri e le tematiche della biologia anche molecolare eo cellulare
