30732 research outputs found
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Transient Switching of NMDA-Dependent Long-Term SynapticPotentiation in CA3-CA1 Hippocampal Synapses to mGluR1-Dependent Potentiation After Pentylenetetrazole-Induced AcuteSeizures in Young Rats
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Sharing the Voice and Experience of our Community Members with Significant Disabilities in the Development of Rehabilitation Games
No full textAbstract We investigated a participatory design of rehabilitation technology for people with disabilities. Conventionally, rehabilitation technology is designed through the collaboration of medical experts and professional engineers. Potential users of the technology are introduced onlyat the testingstageafterthe proof ofconcepthas been established andworkingprototypes have been constructed, leading to insufficient scope for modification. However, rehabilitation technology that does not address the needs of people often results in decreased efficacy and its eventual nonuse. In our study, we used action research to guide the development of rehabilitationtechnology. People withdisabilities wereinvited to participate in designing the assistive technology at the outset of the project and played the role of experts in living with disabilities. They acted as resources and assets in the process of developing and validating the technology.Keywords Rehabilitation.Disabilities.Technology.Actionresearch.Servicelearning. Participatorydesign.Socialinclusion.Engineeringethic
Clinical spectrum of Lyme disease
No full textAbstractLyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion hasbeen steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group ofwhich three genospecies have been systematically associated to Lyme disease: B. burgdorferi sensu stricto Borrelia afzelii andBorrelia garinii. Geographical distribution and clinical manifestations vary according to the species involved. Lyme disease clinicalmanifestations may be divided into three stages. Early localized stage is characterized by erythema migrans in the tick bite site. Earlydisseminated stage may present multiple erythema migrans lesions, borrelial lymphocytoma, lyme neuroborreliosis, carditis, orarthritis. The late disseminated stage manifests with acordermatitis chronica atrophicans, lyme arthritis, and neurological symptoms.Diagnosis is challenging due to the varied clinical manifestations it may present and usually involves a two-step serologicalapproach. In the current review, we present a thorough revision of the clinical manifestations Lyme disease may present.Additionally, history, microbiology, diagnosis, post-treatment Lyme disease syndrome, treatment, and prognosis are discussed.Keywords Lyme disease . Borrelia burgdorferi . Tick-borne diseases . Ixodes . Erythema migrans . Lyme neuroborreliosi
Fourier transform infrared spectroscopy: unlocking fundamentalsand prospects for bacterial strain typing
No full textPersistent Candidemia in adults: underlying causes and clinicalsignificance in the antifungal stewardship era
No full textEradicating MRSA carriage: the impact of throat carriageand Panton-Valentine leukocidin genes on success rate
No full textInfluence of viral load in the outcome of hospitalized patients with influenza virus infection
No full textLabor and Employment Practices: the Rise and Fall of the New Managerialism
No full textSince the beginning of industrial capitalism, labor resistance and control havebeen central problems for management. Yet these problems have varied considerably,in large part depending on the context within which the employmentrelation is embedded and particularly the broader political economy characterizingit. Workplace and management practices have tended to develop in reflectionof this context, while forming an important component of it, with social as well aseconomic consequences. This chapter addresses these practices, the conditionsunder which they have developed from the 1950s to present, and what some oftheir consequences have been. Although focus is on the practices believed to bedominant at various points in time, variation across and within nations is alsoaddressed
Pre-colonial Africa: Diversity in Organization and Management of Economy and Society
No full textManagement was integral to state organization, traditional hierarchical stratificationof authority, and ownership of resources in Africa. The history of dynamicstate formation, challenge of authority and conquest in Africa. Limited separationexisted between state and commercial activity. Islam expanded and conqueredindigenous empires, while some indigenous peoples converted to Islam. Traditionalmanagement was integral to state management. In some geographicallocations, the monarch allowed private enterprise and decentralized managementof commerce. In West Africa, more decentralized commercial managementoccurred, while in East Africa Muslim traders controlled trade routes. Thischapter shows how state formation and business management develop in paralleltrajectories before colonial intervention. Limited organizational structuresemerged as distinct managerial in origin. This chapter illustrates diversity ofmanagement culture and sophistication before the late nineteenth centur