30732 research outputs found
Sort by
Activity of anti-CR3-RP polyclonal antibody against biofilms formed by Candida auris, a multidrug-resistant emerging fungal pathogen
No full textAbstractFungal biofilm has remained a serious medical problem that complicates treatment of mycoses. In particular, once biofilms areformed, they display high levels of resistance against most common antifungals. Candida auris is currently considered as aserious emerging fungal pathogen frequently exhibiting high levels of resistance to antifungals. Recent studies have confirmedthat C. auris shares similarity with Candida albicans in regards to virulence-associated proteins involved in adherence andbiofilm development. Complement receptor 3-related protein (CR3-RP) is one of the key surface antigens expressed by Candidaspecies during biofilmformation. Here, we have investigated the presence of this cell surface moiety on the surface of C. auris, aswell as the potential of anti-CR3-RP polyclonal antibody (Ab) to inhibit biofilm formation by this emerging fungal pathogen.Using indirect immunofluorescence and ELISA, we were able to confirm the presence of CR3-RP in C. auris cells withinbiofilms. Further, not only anti-CR3-RPAb was able to inhibit biofilm formation by multiple C. auris strains when added duringthe adherence phase, but it also demonstrated activity against C. auris 24-h pre-formed biofilms, which compared favorably tolevels of inhibition achieved by treatment with current conventional antifungals fluconazole, amphotericin B, and caspofungin.Overall, our data demonstrate the presence of this antigen on the surface of C. auris and points to the potential of anti-CR3-RPAbin eradication of biofilms formed by this novel fungal pathogen.Keywords CR3-RP . Polyclonal antibody . Biofilm . Resistance . Candida auri
Pembuatan peta dasar pendaftaran menggunakan teknologi UAV (Unmanded Aerial Vehicle) pada pelaksanaan Proyek Jalan Tol Trans Sumatera (Lokasi Desa Bumi Harapan Kecamatan Way Serdang Kabupaten Mesuji) Provinsi Lampung [Tugas Akhir]
No full textBibliografi halaman 97-98xx, 96 halaman : ilustrasi ; 28 cm
Collaborative governance dalam pengembangan objek wisata Horti Park Lampung di Desa Sabah Balau Kecamatan Tanjung Bintang Kabupaten Lampung Selatan [Skripsi]
No full textBibliografi halaman 157-159xxii, 156 halaman : ilustrasi ; 28 cm
Kedudukan Badan Usaha Milik Desa Dalam Upaya Meningkatkan Perekonomian Desa : ( Studi Di BUMDes Swadesa Artha Mandiri Desa Wonomerto Kabupaten Lampung Utara ) [ CD-Skripsi ] / Indah Cintia
No full textAnalisis kontrak pengadaan alat-alat kesehatan (Computed tomography scanner single slice) antara Rumah Sakit Graha Husada Lampung bekerja sama dengan PT. Gardena Mas Lestari [Skripsi]
No full textBibliografi halaman 93-95xv, 92 halaman : ilustrasi ; 28 cm
Analisis Daya Dukung Ekowisata Di Pulau Pisang Kabupaten Pesisir Barat [CD-Skripsi] /Ade Sofiyan
No full textPotensi Dan Persepsi Pengunjung Terhadap Keberadaan Ekowisata Kebun Raya Liwa [CD-Skripsi] /Haqfini Bina Lalika
No full textPengrajin gerabah di Desa Podomoro Kecamatan Pringsewu Kabupaten Pringsewu [Skripsi]
No full textBibliografi halaman 115-117xx, 114 halaman : ilustrasi ; 28 cm
