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Use of Modern Technologies for the Production Concept of Cutting Tool body
No full textThis work focuses on the study of the mechanical properties and microstructure of high-strength maraging steel M300 fabricated using the Selective Laser Melting (SLM) method. In the first phase of the experimental study, the surface roughness, hardness, and dynamic and mechanical properties of the fabricated samples in the as-built state were investigated. In the second phase, the effect of different heat treatment temperatures on the final hardness and microstructure of M300 maraging steel was examined. Specifically, the impact of various aging temperatures on mechanical properties and microstructure was evaluated. Furthermore, the mechanical properties of M300, particularly its compressive yield strength, were studied. The compressive pressure test revealed that the highest yield strength was achieved after solution treatment at 840°C for 1 hour, followed by aging at 500°C for 6 hours. The third phase focused on examining the effect of different cutting conditions and material types on the machinability of M300 maraging steel. The final part of this dissertation involves the design, fabrication, and testing of a milling tool body. The fabricated milling cutter underwent technological tests, and the results were compared with those of a conventionally manufactured milling cutter. The comparison was conducted for face milling, slot machining, and shoulder milling under various cutting conditions and with different machined materials. An additional comparison was made regarding the durability of the inserts used when machining tool steel, with and without flood cooling. Finally, the milling tool body was analyzed using vibrodiagnostics, thermal imaging, and a high-speed camera. In conclusion, it was found that the 3D-printed cutter exhibited a 20 % longer tool life when using flood cooling compared to the conventional cutter
Accounting Directives for Company
No full textThe bachelor's thesis focuses on a proposal to supplement the existing internal company directive for an anonymous company. In the first part, the author of the thesis focused on the theoretical issues of long-term assets, which include their acquisition, valuation, registration, depreciation or disposal. In addition to the definition of long-term assets, this part also contains a characteristic of internal company directives. The second part contains a basic introduction to the company, a brief financial analysis and, last but not least, an assessment of the current state of the company's internal company directives. The last part of the bachelor's thesis is focused on a proposal for amendments to the existing internal organizational directive for long-term assets
3+1 tips on how to incorporate female philosophers into philosophy classes at secondary schools
No full textThis thesis attempts to answer the question of how female philosophers can be incorporated into the teaching of philosophy in secondary schools. It begins by analyzing three Czech secondary school textbooks and examining how female authors are represented in these textbooks. The thesis then presents four 90-minute teaching units and accompanying methodological procedures and worksheets that propose ways of working with female philosophers in Czech secondary school teaching. Three teaching units deal with topics in contemporary philosophy; the first is devoted to the Anthropocene and visions of the future, the second to attitudes toward animals, and the third to the ethics of care and resilience. These three workshops introduce students to both foreign and Czech female philosophers. The fourth teaching unit shows that women philosophers can also be included in the teaching of the history of philosophy and presents the philosophy of the medieval author Christine de Pisan. The work will include a reflection on the teaching units taught, based on feedback from students from interviews with teachers
Comparison of vaccination scenarios in COVID pandemic.
No full textThis thesis analyzes the impact of vaccination against SARS-CoV-2 variants in the Czech Republic during 2021 using an extended Momentum model. The model incorpo- rated vaccination, waning immunity, hospitalizations, deaths, and the age-sex structure of the population. We extended the widely respected Momentum model to include hospitalizations and death, modifying it by specifically drawing each individual's reproduction number to account for superspreading (a minority of people is responsible for the majority of in- fections) and to accurately capture the momentum of the epidemic (i.e., its potential to generate new infections). We estimated the probability of hospitalization and death (both with and without prior hospitalization) using probit regression, and showed that age and sex are significant covariates, with older individuals and males exhibiting higher vulnerability, and vaccinated groups showing lower risks. We then compared the recorded data with hypothetical simulations without vaccina- tion (where a lockdown would be introduced when the risk of hitting hospital capacity arose), which showed that in such a scenario the loss of lives would be more than 50 % higher than observed. Without vaccination and without lockdown, an enormously large hospital capacity would be needed. Sensitivity analyses..
The Media Representation of the 17th November Celebrations - Korzo Národní: From Its Inception to the Present Day
No full textRunoff analysis of selected catchments in Swiss Alps related to variability in snow storage
No full textThe bachelor thesis investigates the impact of interannual climate variability - specifically air temperature, precipitation, and snow accumulation - on the discharge regime of mountain rivers in Switzerland. The main goal was to assess the current state of research in this area and to analyze long-term hydrometeorogical data from selected Swiss catchments for the period 1965-2020. The first part of the thesis presents a review of scientific literature focused on the variability of precipitation, snow amounts, and air temperature, and their influence on the discharge regime of mountain rivers, which is also described. The second part presents the results of the analysis of climate variable trends in Switzerland, their effects on snow accumulation, and subsequent changes in the runoff regime, with a focus on winter and spring discharges. Part of the analysis also examines the role of elevation on these changes. The results show that rising air temperatures are leading to increased winter discharge and a shortening of the snow-covered period, mainly due to the earlier onset of snowmelt. The spring runoff peak is lower, narrower, and occurs earlier. Especially in lower elevation catchments, the role of rainfall on runoff generation is increasing. Below 1400 m a.s.l. snow accumulation is primarily..
The Will of God and Godless Willing: Schopenhauer and Nietzsche on How to Live Without Religion to Guide Us
No full textA trustworthy teacher through the eyes of the pupils
No full textThe aim of this study is to find out how pupils of a selected primary school in Prague describes a trustworthy teacher. Which character traits and behavioural expressions are their favourites or which other attributes are importent in gaining their trust and whether they perceive someone from the teaching staff as trustworthy at the school they attend. Another area examined is whether pupils know that they can also place their trust in professionals in the guidance department. Whether pupils know the people who hold the positions in the school. If pupils are informed about the above topics, will they use the help of these professionals? What discourages pupils from trusting teachers? Have pupils had their trust betrayed by the teacher nce in their lives? The research method chosen for this case study was a Google questionnaire, containing both closed and open-ended questions. The results showed that the majority of pupils in the school would place their trust in a teacher who was friendly, calm and had a sense of humour. From trusting the teacher, pupils are discouraged by the shouting and explosive behaviour of the teacher. Most of the pupils did not encounter the teacher betraying their trust. Pupils in the school are aware of which teachers are part of the school's guidance department, but most..
Development of biosensor for activity monitoring of alkaline phosphatase using oxidative grafting of boron doped diamond electrode
No full textThis thesis builds upon a previous study in which the surface of boron-doped diamond electrodes (BDD) was modified by oxidative grafting of p-aminobenzoic acid. Within this work, the influence of the redox marker [Ru(NH3)6]2+/3+ on the stability of the modified layer was tested, and the effect of pH on the dissociation of carboxyl groups on the modified electrode surface was thoroughly investigated. The experimental pKa value was determined and compared with the theoretical one. Furthermore, the activity of the enzyme alkaline phosphatase (ALP) was monitored on an unmodified BDD electrode using the substrate L-ascorbic acid 2-phosphate (AA2P), which is enzymatically converted to the electrochemically active L-ascorbic acid (AA). The effects of enzyme and substrate concentrations on the course of enzymatic dephosphorylation were studied by voltammetric detection of the generated product signal. In the final part, the modified electrode surface was activated using EDC (N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide) and NHS (N˗hydroxysuccinimide) chemistry, and ALP was covalently immobilized on the electrode surface to create a model enzymatic biosensor. The results confirm the potential of this electrochemical system for the future development of sensors based on the detection of enzymatic activity..
Isolation, structural analysis and in silico prediction of selected ADMET parameters of alkaloids isolated from Croton linearis Jacq. (Euphorbiaceae).
No full textNguyen, T. P.: Isolation, Structural Analysis and In Silico Prediction of Selected ADMET Parameters of Alkaloids Isolated from Croton linearis Jacq. (Euphorbiaceae); Diploma Thesis, Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacognosy and Pharmaceutical Botany, Hradec Králové 2025, 93 pages. The subject of this diploma thesis was the isolation and identification of alkaloids from the dichloromethane extract of Croton linearis Jacq. (Euphorbiaceae) and the subsequent in silico prediction of selected ADMET parameters. The alkaloids (+)-cularine, (+)-glaucine and (-)-laudanidine were isolated from selected fractions (i.e. CL-CH2Cl2-7, CL-CH2Cl2-8 a CL-CH2Cl2-13) using chromatographic methods. The structure of the individual compounds was confirmed using GC-MS, LC-MS, NMR analyses and measurements of specific optical rotation. In the in silico evaluation, physicochemical properties (number of hydrogen bond acceptors and donors, total polar surface area, consensus logarithm of octanol/water partition coefficient), pharmacokinetic properties (gastrointestinal absorption, permeability across the blood- brain barrier, cytochrome inhibition and interaction with P-glycoprotein) and toxicological characteristics (oral LD₅₀, toxicity class) were predicted using the SwissADME..