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Spontaneous recognition of impactful video games: a user-centric classification framework
No full textThe potential impact of a video game is directly conditioned by its recognizability in the public conscience. But classifying video games in this manner can be a challenging endeavor. This paper emphasizes inconsistencies in recognition metrics and the absence of a unified system of classification. It approaches the problem through a twofold methodology involving a systematic literature review exploring existing classifications and genres, and an exploratory survey gathering data on spontaneously recognized video games in Spain. The study utilizes quantitative data to create three lists of video games—most played globally, most representative internationally, and most significant in the Spanish market. The findings reveal complexities in comparing video game data and underscore the importance of comprehensive research frameworks. The study contributes valuable insights into video game recognition dynamics among users, addresses the scarcity of comparative research in the gaming field, revealing the subjective impact of globally recognized video games and highlighting the possible relations between industry trends, spontaneous recognition, and consumer preferences.Sin Financiación2.4 Q3 JCR 20230.746 Q1 SJR 2023No data IDR 2023UE
The CAPN3 p.Lys 254del variant is not always associated with dominant CAPN3-related muscular dystrophy
No full textIntroduction/Aims
Limb-girdle muscular dystrophy R1 (LGMDR1) calpain 3-related usually presents as a recessively transmitted weakness of proximal limb-girdle muscles due to pathogenic variants in the CAPN3 gene. Pathogenic variants in this gene have also been found in patients with an autosomal dominantly inherited transmission pattern (LGMDD4). The mechanism underlying this difference in transmission patterns has not yet been elucidated. Camptocormia, progressive limb weakness, myalgia, back pain, and increased CK levels are common clinical features associated with dominant forms. The p.Lys254del pathogenic variant was associated with camptocormia in two LGMDD4 families. This study aimed to present carriers found in recessively transmitted LGMDR1 families bearing the p.Lys254del variant that do not show muscle weakness.
Methods
DNA sequencing was performed on exon 5 of CAPN3 in family members to establish the carrier status of the pathogenic variant. They were evaluated clinically and MRI was performed when available.
Results
Two families presented with the p.Lys254del pathogenic variant in a homozygous or compound heterozygous state. Family members carrying only the pathogenic variant in the heterozygous state did not demonstrate the myopathic characteristics described in dominant patients. Camptocormia and other severe clinical symptoms were not observed.
Discussion
We conclude that the p.Lys254del pathogenic variant per se cannot be solely responsible for camptocormia in dominant patients. Other undisclosed factors may regulate the phenotype associated with the dominant inheritance pattern in CAPN3 pathogenic variant carriers.PI21/00047Government of the Basque Country, Grant/Award Number: 2021111022CB06/05/11262.8 Q2 JCR 20230.964 Q2 SJR 2023No data IDR 2023UE
La protección jurídica del menor en los esports
No full textTesis inédita presentada en la Universidad Europea de Madrid. Escuela de Doctorado e Investigación. Programa de Doctorado en Actividad Física y DeporteEl ocio de los niños y jóvenes del siglo XXI ha cambiado respecto a siglos anteriores. La suma de
deporte, tecnología, ocio y entretenimiento ha tenido como resultado los esports o deportes
electrónicos, en los que participan miles de niños y jóvenes en España, de forma amateur,
profesional o como juego. Son muchos los beneficios y los riesgos del consumo de videojuegos por
menores y de la competición organizada, que se analizan desde un prisma jurídico, estudiando la
legislación vigente para la protección de los menores como profesionales y también como
consumidores y usuarios de este tipo de entretenimiento audiovisual organizado. La segunda parte
de la tesis incluye una investigación cuantitativa cuyo objetivo ha sido analizar los comportamientos
hostiles y los tratos discriminatorios en los esports en jugadores entre los 9 y 17 años, teniendo en
cuenta los diferentes tipos de videojuegos, con la finalidad de averiguar aquellos en los que se dan
mayores conductas tóxicas, así como los patrones de discriminación que suelen guiar estos
comportamientos que son, principalmente, género y raza. Como parte final, entendiendo que la
legislación existente no es suficiente para la debida protección de los menores en los esports, se
proponen una serie de medidas dirigidas a legisladores y responsables de la industria para la
protección de los niños que participan de los esports: actuaciones preventivas, de gobierno y
sancionadoras que protejan la salud mental, el bienestar y los derechos de uno de los grupos de
población más vulnerable.Children’s and young people’s leisure in the 21st century has changed compared to previous
centuries. The combination of sports, technology, leisure and entertainment has resulted in esports
or electronic sports, in which thousands of children and young people in Spain participate, either
at an amateur level, professionally or as a game. The consumption of video games and the
organised competitions of minors bring about many benefits and risks, which are herein analysed
from a legal perspective, including a study of the current legislation for the protection of minors as
professionals as well as consumers and users of this type of organised audiovisual entertainment.
The second part of the thesis includes a quantitative research, whose objective has been to analyse
hostile behaviours and discriminatory treatment in esports among players between the ages of 9 and 17, taking into account the different types of video games, with the aim of finding out those in
which toxic behaviours are more prevalent, as well as the patterns of discrimination that usually
guide such behaviours, which are mainly gender and race. Finally, it being understood that the
existing legislation is not sufficient for minors’ due protection in esports, a series of measures are
proposed, aimed at legislators and at those in charge within the industry, for the protection of
children who participate in esports: preventive, governmental and sanctioning actions that protect
the mental health, well-being and rights of one of the most vulnerable population groups.No data 2022UE
Síntomas y factores biopsicosociales en mujeres con endometriosis
No full textTesis inédita presentada en la Universidad Europea de Madrid. Escuela de Doctorado e Investigación. Programa de Doctorado en Biomedicina y Ciencias de la SaludIntroducción: La endometriosis es una enfermedad ginecológica crónica y benigna
que afecta al 5-10% de las mujeres en edad reproductiva en todo el mundo. Se
caracteriza por la presencia de tejido endometrial más allá de la cavidad uterina,
principalmente en los ovarios y otros órganos pélvicos. Asociado a esto, se
ha demostrado que la patogenia de la endometriosis es multifactorial, por lo
que se han propuesto varias teorías que incluyen la menstruación retrógrada,
metaplasia celómica, restos embrionarios y la diseminación linfovascular.
Los síntomas de la endometriosis pueden incluir dolor pélvico intenso,
dismenorrea, dispareunia, disuria, infertilidad y fatiga, con un impacto negativo
en la fertilidad de la mujer. El diagnóstico puede dilatarse entre 8 a 10 años una
vez que aparecen los síntomas. Además de los síntomas clínicos, las mujeres con
endometriosis experimentan una variedad de síntomas no clínicos que incluyen
depresión, fatiga y falta de energía.
Asimismo, la endometriosis también tiene un impacto adverso en el bienestar
físico, sexual, emocional, mental y social, además de un efecto negativo en la
calidad de vida de las mujeres que sufren la enfermedad, originando estados de
ansiedad y depresión.
La calidad de vida asociada a la salud es un concepto multidimensional que
incluye los aspectos físicos, psicológicos y sociales que están relacionados
con una enfermedad específica. En este caso particular, estudiar los factores
biopsicosociales y la calidad de vida de las pacientes con endometriosis es
importante en el marco de esta tesis doctoral, que persigue brindar un panorama
epidemiológico y clínico de las mujeres afectadas, pero que, además, pretende
demostrar el impacto sobre los factores psicológicos y sociales, y así conocer las
consecuencias en la calidad de vida de las mujeres con esta patología. Finalmente, el propósito de este estudio es proporcionar información
actualizada en este campo, que genere a futuro nuevas líneas de investigación,
cuyos resultados garanticen la propuesta e implementación de programas de
apoyo donde la fisioterapia esté incluida dentro de las unidades específicas de
endometriosis.
Hipótesis: Las mujeres con endometriosis poseen peor calidad de vida que las
mujeres sanas, siendo afectadas por los síntomas de la enfermedad y los factores
biopsicosociales como el dolor pélvico, función sexual, ansiedad, depresión y
sensibilización central, con diferencias estadísticamente significativas entre las
mujeres sanas y las mujeres con endometriosis con y sin intervención quirúrgica.
Objetivos: Se planteó como objetivo general analizar los síntomas y factores
biopsicosociales que afectan a las mujeres con diagnóstico de endometriosis.
Como objetivos específicos de esta tesis doctoral se propusieron determinar las
variables sociodemográficas en las mujeres con y sin endometriosis; comparar
el dolor pélvico crónico y funcional, su frecuencia, dimensiones, intensidad,
zona afectada, la percepción sobre la salud y desempeño diario en mujeres con
endometriosis; contrastar las dimensiones que componen la calidad de vida;
relacionar entre los grupos estudiados las subescalas que conforman la función
sexual femenina; detectar e identificar la ansiedad y la depresión; examinar las
patologías que confluyen en los procesos de sensibilización central; establecer
modelos de predicción para determinar qué variables influyen o explican
de forma significativa la calidad de vida de las mujeres participantes en este
estudio, es decir, mujeres con endometriosis intervenidas y no intervenidas
quirúrgicamente y mujeres sanas.
Material y Métodos: Se realizó un estudio descriptivo y transversal. Se
incluyeron 214 mujeres de las cuales 136 mujeres presentaron un diagnóstico clínico de endometriosis seleccionadas a través de las Asociaciones de Afectadas
de Endometriosis de Euskadi, Cataluña, Valencia, Madrid y Extremadura (GE). De
ellas, 74 mujeres habían recibido tratamiento quirúrgico a lo largo de la evolución
de su enfermedad (EIQ) y 62 mujeres recibieron tratamiento no invasivo (ESIQ).
El grupo control estuvo conformado por 78 mujeres sanas (GC). Por otra parte,
se aplicaron 6 cuestionarios validados para observar los síntomas asociados
a la endometriosis, se transcribieron en formato digital y se proporcionaron
mediante un enlace para ser completados vía telemática. En ese orden de ideas,
el dolor pélvico se evaluó a través del cuestionario de dolor pélvico crónico en la
mujer (CPPQ-Mohedo). A su vez, el nivel de calidad de vida se valoró mediante
la puntuación total del Cuestionario de Calidad de Vida en Endometriosis (EHP 30) y sus 5 dominios: dolor, bienestar emocional, autocontrol, apoyo social y
autoimagen. La función sexual femenina fue determinada por la aplicación del
Cuestionario de Función Sexual Femenina (FSFI). En cuanto al estado del ánimo,
el nivel de ansiedad se evaluó mediante las puntuaciones del Inventario de
Ansiedad Rasgo-Estado (STAI) y el nivel de depresión se valoró a través de las
puntuaciones totales del Inventario de Depresión de Beck (BDI-II). Por último,
la sensibilización central se estudió a través de la puntuación total del Índice de
Sensibilización Central (ISC). Para todos los análisis, la significancia estadística se
consideró para valores de p < 0,05.
Resultados: La edad fue de 31,6 ± 7,7 años en el grupo control y de 36,7 ± 5,8
años en el grupo de mujeres con endometriosis con diferencia estadísticamente
significativa (p<0,05). En el 63,6% de las mujeres con endometriosis, el tiempo
de evolución de la enfermedad fue de 10,5±6,1 años. El 50% de las mujeres del
grupo con endometriosis realizaban actividad física y el 49,3% eran no fumadoras.
En ambos grupos en estudio, el estado civil más frecuente fue vivir en pareja,
seguido de estar casada y soltera con 34,1% y 22,4% respectivamente y con
diferencias estadísticamente significativas (p<0,05). Respecto a la conformación
de la unidad familiar, estuvo principalmente constituida por 2 miembros (43,5%)
en ambos grupos. Tanto en las mujeres con endometriosis y aquellas sanas,
la mayoría de las mujeres estudiadas se encontraban laboralmente activas
(72,4%). Predominaron las mujeres con estudios universitarios (70,6%), aunque
la proporción de mujeres universitarias en el GC fue superior (87,2%) a la
encontrada en el GE (61%). El 61,3% de ESIQ y el 63,5% de EIQ manifestaron
haber sentido dolor perineal, mientras que el 82,3% y 86,5% presentaron
dolor infraumbilical en ESIQ y EIQ, respectivamente. El dolor en la vulva y el
clítoris fue inferior al 30% y el 20% respectivamente en las mujeres ESIQ y EIQ.
Relacionado con la frecuencia del dolor, el 39,7% de todas las mujeres evaluadas
presentaron dolor “algunas o muchas veces” siendo mayor en ESIQ (51,6%) que
en EIQ (48,6%). El dolor en dos zonas fue más frecuente en ESIQ (41,9%) y en EIQ
(40,5%) y la frecuencia del dolor de “algunas o muchas veces” fue 40,6% en ESIQ
y 41,7% en EIQ con diferencias estadísticamente significativas (p<0,05). El 53,5%
de las mujeres evaluadas presentaron dolor durante las relaciones sexuales, y
en ESIQ fue del 78,8% y 66,7% en EIQ. El parámetro de la Escala Visual Analógica
(EVA) en EIQ y ESIQ presentaron niveles de dolor significativos (mediana=4). El
41,9% de ESIQ y el 39,2% de EIQ, manifestaron sufrir “mucho” impedimento
cuando realizaban sus actividades. La percepción de la salud como “fatal” se
observó en un 48,4% en las mujeres con ESIQ y un 33,8% en las mujeres con EIQ.
La evaluación de la calidad de vida realizada con el cuestionario EHP-30 arrojó
una mediana en el caso del dolor de 55,7 y 50 para las mujeres de los grupos ESIQ
y EIQ respectivamente, mientras que el autocontrol fue de 62,5 en ESIQ y 64,58
para EIQ. La mediana del dominio bienestar emocional fue de 62,5 y 52,08 para
ESIQ y EIQ. Para el dominio apoyo social, los resultados fueron de 62,5 en ESIQ y
62,75 en EIQ, mientras que en la autoimagen, los valores fueron de 66,66 y 50 para
ESIQ y EIQ, respectivamente. Las mujeres con endometriosis de los grupos ESIQ y EIQ presentaron un deterioro en el deseo, excitación, lubricación, orgasmos,
satisfacción y dolor en las relaciones sexuales. La mediana de la ansiedad estado
y rasgo superó los 70 puntos en las mujeres con endometriosis. La mediana de la
depresión fue de 16 puntos tanto para ESIQ y EIQ. Las mujeres con endometriosis
(ESIQ-EIQ) presentaron niveles de sensibilización central significativos (mediana
de 53 a 54 en ESIQ y EIQ, respectivamente). Relacionado con el espectro de
patologías asociadas al dolor y la sensibilización central, 5 de ellas, ansiedad/
pánico, lesión cervical, migraña, depresión y síndrome de colon irritable fueron
las más frecuentes entre las mujeres estudiadas con endometriosis. Se demostró
que el dolor pélvico crónico, la función sexual, la sensibilización central, ansiedad
rasgo, ansiedad estado y la depresión son variables predictoras de la calidad
de vida. En las variables analizadas se encontraron diferencias estadísticamente
significativas entre los grupos de mujeres con endometriosis y el GC (p<0,05). Sin
embargo, no se observaron diferencias estadísticamente significativas entre EIQ
y ESIQ (p>0,05) en casi todas las variables estudiadas, excepto para la quemazón
al orinar y la relación entre las zonas y frecuencia del dolor.
Conclusión: La endometriosis tiene importantes repercusiones físicas, psicológicas,
sexuales, familiares, de pareja, sociales, educativas, ocupacionales y laborales que
afectan la calidad de vida de las mujeres.Introduction: Endometriosis is a chronic and benign gynecological disease that
affects 5-10% of women of reproductive age worldwide. It is characterized by
the presence of endometrial tissue beyond the uterine cavity, mainly in the
ovaries and other pelvic organs. In addition to this, it has been shown that
the pathogenesis of endometriosis is multifactorial, for which several theories
have been proposed, including retrograde menstruation, coelomic metaplasia,
embryonic remnants and lymphovascular dissemination.
Symptoms of endometriosis can include severe pelvic pain, dysmenorrhea,
dyspareunia, dysuria, infertility, and fatigue, with a negative impact on a woman’s
fertility. Diagnosis can take 8 to 10 years after symptoms appear. In addition
to clinical symptoms, women with endometriosis experience a variety of non clinical symptoms including depression, fatigue, and lack of energy.
Likewise, endometriosis also has an adverse impact on physical, sexual,
emotional, mental and social well-being, as well as a negative effect on the
quality of life of women who suffer from the disease, causing states of anxiety
and depression.
Health-associated quality of life is a multidimensional concept that includes
physical, psychological, and social aspects that are related to a specific disease. In
this particular case, studying the biopsychosocial factors and the quality of life of
patients with endometriosis is important within the framework of this doctoral
thesis, which aims to provide an epidemiological and clinical overview of affected
women, but which also aims to demonstrate the impact on psychological and
social factors, and thus know the consequences on the quality of life of women
with this pathology. Finally, the purpose of this study is to provide updated information in this field,
which will generate new lines of research in the future, the results of which
will guarantee the proposal and implementation of support programs where
physiotherapy is included within specific endometriosis units.
Hypothesis: Women with endometriosis have worse quality of life than healthy
women, being affected by disease symptoms and biopsychosocial factors such
as pelvic pain, sexual function, anxiety, depression and central sensitization,
with statistically significant differences between healthy women and women
with endometriosis with and without surgical intervention.
Objectives: The general objective was to analyze the symptoms and
biopsychosocial factors that affect women diagnosed with endometriosis. As
specific objectives of this doctoral thesis, it was proposed to determine the
sociodemographic variables in women with and without endometriosis; compare
chronic and functional pelvic pain, its frequency, dimensions, intensity, affected
area, perception of health and daily performance in women with endometriosis;
contrast the dimensions that make up the quality of life; to relate the subscales
that make up the Female Sexual Function among the studied groups; detect and
identify anxiety and depression; examine the pathologies that converge in the
processes of Central Sensitization; establish prediction models to determine
which variables significantly influence or explain the Quality of Life of the
women participating in this study, that is, women with endometriosis who have
undergone surgery and who have not undergone surgery and healthy women.
Material and Methods: A descriptive and cross-sectional study was carried
out. A total of 214 women were included, of which 136 women presented a
clinical diagnosis of endometriosis who were selected from the Associations
of People Affected by Endometriosis of Euskadi, Catalonia, Valencia, Madrid
and Extremadura (GE). Of these, 74 women had received surgical treatment
throughout the evolution of their disease (EIQ) and 62 women received non invasive treatment (ESIQ). The control group consisted of 78 healthy women
(CG). On the other hand, 6 validated questionnaires were applied to observe
the symptoms associated with endometriosis, they were transcribed in digital
format and provided through a link to be completed electronically. In that order
of ideas, pelvic pain was evaluated through the questionnaire on chronic pelvic
pain in women (CPPQ-Mohedo). In turn, the level of quality of life was assessed
using the total score of the endometriosis quality of life questionnaire (EHP-30)
and its 5 domains: pain, emotional well-being, self-control, social support and
self-image. Female sexual function was determined by applying the female sexual
function questionnaire (FSFI). Regarding mood, the level of anxiety was assessed
using the Trait-State Anxiety Inventory (STAI) scores and the level of depression
was assessed through the total scores of the Beck Depression Inventory (BDI-II).
Finally, central sensitization was studied through the total score of the Central
Sensitization Index (CSI). For all analyzes, statistical significance was considered
for values of p <0.05.
Results: Age was 31.6 ± 7.7 years in the control group and 36.7 ± 5.8 years in
the group of women with endometriosis with a statistically significant difference
(p <0,05). In 63.6% of the women with endometriosis, the time of evolution of
the disease was 10.5 ± 6.1 years. 50% of the women in the endometriosis group
performed physical activity and 49.3% were non-smokers. In both groups under
study, the most frequent marital status was living with a partner, followed by
being married and single with 34.1% and 22.4% respectively and with statistically
significant differences (p <0.05). Regarding the formation of the Family Unit, it
was mainly made up of 2 members (43.5%) in both groups. In both women with
endometriosis and healthy women, most of the women studied were in active employment (72.4%). Women with university studies (70.6%) predominated,
although the proportion of university women in the CG was higher (87.2%) than
that found in the EG (61%). 61.3% of the ESIQ and 63.5% of the EIQ stated that
they had felt perineal pain, while 82.3% and 86.5% had infra-umbilical pain in
the ESIQ and EIQ, respectively. Pain in the vulva and clitoris was less than 30%
and 20% respectively in the ESIQ and EIQ women. Related to the frequency of
pain, 39.7% of all the women evaluated had pain “some or many times”, being
greater in the ESIQ (51.6%) than in the EIQ (48.6%). Pain in two areas was more
frequent in ESIQ (41.9%) and EIQ (40.5%) and the pain frequency of “some or
many times” was 40.6% in ESIQ and 41.7 % in EIQ with statistically significant
differences (p <0.05). 53.5% of the women evaluated presented pain during
sexual intercourse, and in ESIQ it was 78.8%, and 66.7% in EIQ. The parameter
of the Visual Analogue Scale (VAS) in EIQ and ESIQ presented significant pain
levels (median = 4). 41.9% of ESIQ and 39.2% EIQ, stated that they suffered
from “a lot” of disability when they carried out their activities. The perception
of health as “dreadful” was observed in 48.4% in women with EISQ and 33.8%
in women with EIQ. The evaluation of quality of life carried with the EPH-30
questionnaire showed a median in the case of pain was 55.7 and 50 for women
in the ESIQ and EIQ groups respectively, while self-control was 62.5 in ESIQ and
64.58 for EIQ. The median of the emotional well-being domain was 62.5 and
52.08 for ESIQ and EIQ. For the domain social support, the score was 62.5 in
ESIQ and 62.75, while for self-image, the values were 66.66 and 50 for ESIQ
and EIQ respectively. Women with endometriosis in the ESIQ and EIQ groups
had impaired desire, arousal, lubrication, orgasms, satisfaction, and pain during
sexual intercourse. Median state and trait anxiety scores exceeded 70 points
in women with endometriosis. The median depression was 16 for both ESIQ
and EIQ. Women with endometriosis (ESIQ-EIQ) presented significant levels of
central sensitization (median of 53 to 54 in ESIQ and EIQ respectively). Related to the spectrum of pathologies associated with pain and central sensitization,
5 of them, anxiety/panic, cervical injury, migraine, depression and irritable
bowel syndrome were the most frequent among the women studied with
endometriosis. Chronic pelvic pain, sexual function, central sensitization, trait
anxiety, state anxiety, and depression were shown to be predictors of quality
of life. In the variables analyzed, statistically significant differences were found
between the groups of women with endometriosis and CG (p <0.05). However,
no statistically significant differences were observed between EIQ and ESIQ (p>
0.05) in almost all the variables studied, except for burning when urinating and
the relationship between areas and frequency of pain.
Conclusion: Endometriosis has important physical, psychological, sexual, family,
relationships, social, educational, occupational and work repercussions that
affect the quality of life of women.No data 2022UE
Solo diez usuarios son responsables de la desinformación a gran escala en Twitter
No full textSin FinanciaciónNo data JCR 2023; No data SJR 2023; No data IDR 2023UE
La creación del cómic como estrategia para el desarrollo del pensamiento crítico: Una propuesta didáctica en el grado de periodismo
No full textLa presente experiencia parte de un proyecto de investigación que pre-tende poner en práctica ciertas capacidades del pensamiento crítico del alumnado de Periodismo a través de la elaboración de reportajes perio-dísticos en formato cómic sobre distintos aspectos del fenómeno migra-torio, pues el pensamiento crítico no implica únicamente la capacidad de cuestionar y evaluar ideas y argumentos, sino que construye nuevos conocimientos partiendo de la comprensión reflexiva de la realidad.Ayudas a la Investigación 2022-2023 Santander UniversidadesFundación de la Universidad EuropeaSPI 2022UE
Researching Social Media with Children #DigitalEthnography #Storytelling
No full textReflecting on the methodological issues involved in researching digital spaces with children, this book shares good practices and delves into the ethics of such research.
Social media has completely redefined how children and young people relate to each other, express themselves, and present their identities and sexualities. Yet researching social media can be a difficult and daunting task given the ephemerality of the content, its contextual hyperspecificity, the complex power relationships between users, celebrity culture, digital capitalism, and the ethical issues that arise from the reimagining of the public/private space. Using digital ethnography and creative digital storytelling workshops with children and young people aged 13-15 and 13-18 on TikTok, Instagram, and Twitch, this book studies their interactions, language, codes, the risks they take, and the victimizations they suffer.
Researching Social Media with Children will be of use to social scientists conducting online research, and to students and scholars of media studies, digital criminology, psychology, and sociology.
[The authors draw on experiences from studies carried out in Spain on children and social media by the Knowledge-Research Group on Social Problems at Universidad Europea de Madrid.]CIPI/22.260CIPI/20/171CIPI/213006.482022/UEM22SPI 2022UE
Gender-specific differences in spinal alignment and muscle power in Parkinson ́s disease patients
No full textParkinson’s disease (PD) is an advancing neurodegenerative disorder characterized by spinal anomalies and muscular weakness, which may restrict daily functional capacities. A gender-focused examination of these effects could provide valuable insights into customized rehabilitation strategies for both sexes. Purpose: This study investigates the influence of spinal alignment on lower-limb function during the sit-to-stand (STS) movement in patients with Parkinson’s disease compared to healthy individuals. Methods: A cross-sectional study was conducted with 43 consecutive patients with PD (25 males and 18 females; average age 73.7 ± 7.1 years) and 42 healthy controls (22 males and 20 females; average age 69.8 ± 6.0 years). Assessments included the International Physical Activity Questionnaire (IPAQ), Hoehn and Yahr staging, and measurements of vertical deviations from several spinal landmarks. Lower-limb muscle power during the STS task was evaluated using the Muscle Quality Index (MQI). Results: Both absolute (Watts) and relative (Watts/Kg) muscle power in the lower limbs were notably decreased in the PD group compared to the control group. Within the PD cohort, muscle power showed a negative relationship with age and a positive association with the degree of lumbar lordosis (PL-L3). Importantly, gender-specific analysis revealed that male patients with PD had significantly higher lower-limb muscle power compared to female patients with PD, highlighting the need for gender-tailored therapeutic approaches. Conclusions: The findings suggest that preserving lumbar lordosis is crucial for maintaining effective lower-limb muscle biomechanics in individuals with Parkinson’s disease.Sin Financiación3.0 Q1 JCR 20230.667 Q2 SJR 2023No data IDR 2023UE
Characterization of a natural model of adult mice with different rate of aging
No full textAging is a heterogeneous process, so individuals of the same age may be aging at a different rate. A natural model of premature aging in mice have been proposed based on the poor response to the T-maze. Those that take longer to cross the intersection are known as Prematurely Aging Mice (PAM), while those that show an exceptional response are known as Exceptional non-PAM (E-NPAM), being the rest non-PAM (NPAM). Although many aspects of PAM and E-NPAM have been described, some aspects of their brain aging have not been studied. Similarly, it is known that PAM, NPAM and E-NPAM show a different rate of aging and longevity, but the differences between these three groups in behavior, immune function and oxidative-inflammatory state are unknown. The present study aims to deepen the study of brain aging in PAM and E-NPAM, and to study the differences in behavior, immunity, and oxidative-inflammatory state of peritoneal leukocytes between PAM, NPAM and E-NPAM. Results show deteriorated brains in PAM. Moreover, NPAM show an oxidative state similar to E-NPAM, an anxiety similar to PAM, and an intermediate immunity and lifespan between PAM and E-NPAM. In conclusion, immune function seems to be more associated with the longevity achieved.This research was funded by the Research Group UCM ( 910379 ).5.6 Q1 JCR 20221.577 Q1 SJR 2023No data IDR 2022UE
