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Rouleaux red blood cells splitting in microscopic thin blood smear images via local maxima, circles drawing, and mapping with original RBCs.
Get PDFSplitting the rouleaux RBCs from single RBCs and its further subdivision is a challenging area in computer-assisted diagnosis of blood. This phenomenon is applied in complete blood count, anemia, leukemia, and malaria tests. Several automated techniques are reported in the state of art for this task but face either under or over splitting problems. The current research presents a novel approach to split Rouleaux red blood cells (chains of RBCs) precisely, which are frequently observed in the thin blood smear images. Accordingly, this research address the rouleaux splitting problem in a realistic, efficient and automated way by considering the distance transform and local maxima of the rouleaux RBCs. Rouleaux RBCs are splitted by taking their local maxima as the centres to draw circles by mid-point circle algorithm. The resulting circles are further mapped with single RBC in Rouleaux to preserve its original shape. The results of the proposed approach on standard data set are presented and analyzed statistically by achieving an average recall of 0.059, an average precision of 0.067 and F-measure 0.063 are achieved through ground truth with visual inspection
Genetic Algorithm Optimisation of PID Controllers for a Multivariable Process
Get PDFThis project is about the design of PID controllers and the improvement of outputs in multivariable processes. The optimisation of PID controller for the Shell oil process is presented in this paper, using Genetic Algorithms (GAs). GAs are used to automatically tune PID controllers according to given specifications. They use an objective function, which is specially formulated and measures the performance of controller in terms of time-domain bounds on the responses of closed-loop process. A specific objective function is suggested that allows the designer for a single-input, single-output (SISO) process to explicitly specify the process performance specifications associated with the given problem in terms of time-domain bounds, then experimentally evaluate the closed-loop responses. This is investigated using a simple two-term parametric PID controller tuning problem. The results are then analysed and compared with those obtained using a number of popular conventional controller tuning methods. The intention is to demonstrate that the proposed objective function is inherently capable of accurately quantifying complex performance specifications in the time domain. This is something that cannot normally be employed in conventional controller design or tuning methods. Finally, the recommended objective function will be used to examine the control problems of Multi-Input-Multi-Output (MIMO) processes, and the results will be presented in order to determine the efficiency of the suggested control system
Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability
Get PDFWe examined the effects of whey versus collagen protein on skeletal muscle cell signalling responses associated with mitochondrial biogenesis and protein synthesis in recovery from an acute training session completed with low carbohydrate (CHO) availability. In a repeated measures design (after adhering to a 36-h exercise-dietary intervention to standardise pre-exercise muscle glycogen), eight males completed a 75-min non-exhaustive cycling protocol and consumed 22 g of a hydrolysed collagen blend (COLLAGEN) or whey (WHEY) protein 45 min prior to exercise, 22 g during exercise and 22 g immediately post-exercise. Exercise decreased (P0.05) was observed for p53, Parkin and Beclin1 mRNA. Exercise suppressed (P<0.05) p70S6K1 activity in both conditions immediately post-exercise (≈ 25 fmol.min-1.mg-1). Post-exercise feeding increased p70S6K1 activity at 1.5 h post-exercise (P<0.05), the magnitude of which was greater (P <0.05) in WHEY (180 ± 105 fmol.min-1.mg-1) versus COLLAGEN (73 ± 42 fmol.min-1.mg-1). We conclude that protein composition does not modulate markers of mitochondrial biogenesis when in recovery from a training session deliberately completed with low CHO availability. In contrast, whey protein augments post-exercise p70S6K activity compared with hydrolysed collagen, as likely mediated via increased leucine availability
Primates in peril: the significance of Brazil, Madagascar, Indonesia and the Democratic Republic of the Congo for global primate conservation
Get PDFPrimates occur in 90 countries, but four—Brazil, Madagascar, Indonesia, and the Democratic Republic of the Congo (DRC)—harbor 65% of the world’s primate species (439) and 60% of these primates are Vulnerable, Endangered, or Critically Endangered (IUCN Red List of Threatened Species 2017-3). Considering their importance for global primate conservation, we examine the anthropogenic pressures each country is facing that place their primate populations at risk. Habitat loss and fragmentation are main threats to primates in Brazil, Madagascar and Indonesia. However, in DRC hunting for the commercial bushmeat trade is the primary threat. Encroachment on primate habitats driven by local and global market demands for food and non-food commodities hunting, illegal trade, the proliferation of invasive species, and human and domestic-animal borne infectious diseases cause habitat loss, population declines, and extirpation. Modeling agricultural expansion in the 21st century for the four countries under a worst-case-scenario, showed a primate range contraction of 78% for Brazil, 72% for Indonesia 62% for Madagascar and 32% for DRC. These pressures unfold in the context of expanding human populations with low levels of development. Weak governance across these four countries may limit effective primate conservation planning. We examine landscape and local approaches to effective primate conservation policies and assess the distribution of protected areas and primates in each country. P rimates in Brazil and Madagascar have 38% of their range inside protected areas, 17% in Indonesia and 14% in DRC, suggesting that the great majority of primate populations remain vulnerable. We list the key challenges faced by the four countries to avert primate extinctions now and in the future. In the short term, effective law enforcement to stop illegal hunting and illegal forest destruction is absolutely key. Long-term success can only be achieved by focusing local and global public awareness, actively engaging with international organizations, multinational businesses and consumer nations to reduce unsustainable demands on the environment. Finally, the four primate range states need to ensure that integrated, sustainable land-use planning for economic development includes the maintenance of biodiversity and intact, functional natural ecosystems
Variations of Collagen-Encoding Genes are Associated with Exercise-Induced Muscle Damage
No full textWe investigated whether single nucleotide polymorphisms (SNPs) within genes encoding the alpha-1 chain of type I (COL1A1, rs2249492; rs1800012), type II (COL2A1, rs2070739) and type V (COL5A1, rs12722) collagen were associated with the variable response to exercise-induced muscle damage (EIMD). Knee extensor muscle strength and soreness were assessed pre-, post-, and 48h post-EIMD (120 maximal eccentric knee extensor contractions) in 65 young healthy participants, who were genotyped for the aforementioned SNPs. We found that COL1A1 (minor) T-allele carriers (rs1800012) and (major) T-allele homozygotes (rs2249492) were generally weaker (p≤0.019); and (minor) A-allele carriers of COL2A1 (p=0.002) and (major) T-allele carriers COL5A1 (p=0.004) SNPs reported greater muscle soreness, all compared to their respective major (rs1800012; rs2070739) and minor (rs2249492; rs12722) allele homozygote counterparts. To conclude, the risk alleles of these four SNPs appear to negatively influence muscle strength and post-EIMD recovery, possibly via a dysregulated collagen network affecting the muscle’s mechanical properties
Zanthoamides G-I: Three new alkamides from Zanthoxylum zanthoxyloides
Get PDFThree new alkamides, zanthoamides G-I (1-3), together with ten known compounds, araliopsine, skimmianine, N-methylplatydesminium cation, isoplatydesmine, myrtopsine, atanine, N-methylatanine, sesamin, hesperetin and hesperidin, were isolated from the fruits of Zanthoxylum zanthoxyloides. Their structures were elucidated by spectroscopic means. All isolated compounds were assessed for their cytotoxicity against A549, MCF7, PC3 and PNT2 cell lines. Among the alkamides, only zanthoamide G (1) showed low level of cytotoxicity against MCF7 cells
The XXL Survey: XXX. Characterisation of the XLSSsC N01 supercluster and analysis of the galaxy stellar populations
Get PDFSuperclusters form from the largest enhancements in the primordial density perturbation field and extend for tens of Mpc, tracing the large-scale structure of the Universe. We characterise XLSSsCN01, a rich supercluster at z~0.3 detected in the XXL Survey, composed of X-ray clusters of different virial masses and luminosities. As one of the first studies on this topic, we investigate the stellar populations of galaxies in different environments in the supercluster region. We study a magnitude-limited (r10.8) of galaxies in the virialised region and in the outskirts of 11 XLSSsCN01 clusters, in high- and low-density field. We compute the stellar population properties of galaxies using spectral energy distribution and spectral fitting techniques, and study the dependence of star formation rates (SFR), colours, and stellar ages on environment. For r-12 and with (g-r)_rf10.8, no trends with environment emerge, as massive galaxies are mostly already passive in all environments. No differences among low- and high-density field members and cluster members emerge in the sSFR-mass relation. The luminosity-weighted age-mass relation of the passive populations within cluster virial radii show signatures of recent environmental quenching. The study of luminous and massive galaxies in this supercluster shows that while environment has a prominent role in determining the fractions of SFing/blue galaxies, its effects on the star formation activity in SFing galaxies are negligible
A BPA Approach to the Shroud of Turin
Get PDFAn investigation into the arm and body position required to obtain the blood pattern visible in the image of the Shroud of Turin, was performed using a living volunteer. The two short rivulets on the back of the left hand of the Shroud are only consistent with a standing subject with arms at a ca 45° angle. This angle is different from that necessary for the forearm stains, which require nearly vertical arms for a standing subject. The BPA of blood visible on the frontal side of the chest (the lance wound) shows that the Shroud represents the bleeding in a realistic manner for a standing position whilst the stains at the back - of a supposed post-mortem bleeding from the same wound for a supine corpse - are totally unrealistic. Simulation of bleeding from the nail wounds contacting wood surfaces yielded unclear results
TIIG Cumbria overview report: Emergency Department data collection and overview (April 2014 to March 2017)
Get PDFLate Pleistocene humans in Sri Lanka used plant resources: A phytolith record from Fahien rock shelter
Get PDFLittle is known of the human use of rainforest plant resources of prehistoric Sri Lanka due to the lack of preservation of organic material and the effects of various destructive taphonomic processes. Phytoliths recovered from a AMS radiocarbon and OSL dated sequence at Fahien Rock Shelter indicate interactions of anatomically modern humans with the lowland rainforests of south-western Sri Lanka from 44,952–47,854 cal. BP to 11,936–12,239 cal. BP. During this period, the Rock Shelter occupants extracted their livelihood from a number of wild plants including bananas, rice, breadfruits, durians, canarium and species of palm and bamboo. These taxa are associated with present-day disturbed lowland rainforests. Gathering and processing of plant resources by existing modern rainforest foragers cannot directly be compared with the subsistence activities of the Late Pleistocene Rock Shelter occupants. © 2018 Elsevier B.V
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