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Unsupervised Self-testing as Part Public Health Screening for HIV in Resource-Poor Environments: Some Ethical Considerations
Get PDFAn Assessment of the Hydration Status of Recreational Endurance Athletes during Mountain Marathon Events.
No full textChanges in hydration status have been shown to have deleterious effects on physiological functioning, physical performance, mental decision making, and subjective sensation of effort. This exploratory study assessed the hydration status of athletes taking part in mountain marathon events and the implications on performance, cognition and well-being markers. Twenty-nine male recreational athletes from the Original Mountain Marathon (OMM) and nineteen from the Longmynd Hike (LH) provided urine samples before, at mid-point (in the OMM) and after the events. Body mass; reaction time tests; and subjective ratings of well-being and effort were also collected/performed at these time points. Post-urine specific gravity (Usg) values [(OMM: 1.023 (range: 1.008 – 1.038) g/ml; LH: 1.024 (range: 1.014 – 1.035) g/ml] were significantly higher than pre-values [(OMM: 1.013 (range: 1.002 – 1.026) g/ml; LH: 1.013 (range: 1.002 – 1.026) g/ml] in both events (p 0.05). There was no association between hydration status and overall performance in the LH, whilst change in Usg from pre- to mid-event was positively associated with performance in the OMM (r = .561, p = 0.004). Whilst no associations were observed between hydration status and reaction time, rate of perceived exertion and subjective ratings of nausea showed positive associations with Usg. These findings suggest that although changes in hydration status of this level may not significantly affect performance, they can impact on participant sensations of effort and well-being
Sedimentation, re-sedimentation and chronologies in archaeologically-important caves: problems and prospects
No full textExcavations in the photic zones of caves have provided cornerstone archaeological sequences in many parts of the world. Before the appearance of modern dating techniques, cave deposits provided clear evidence for the antiquity, relative ages and co-occurrence of ancient human remains, material culture and fauna. Earlier generations of archaeologists had generally rather limited understanding of taphonomic and depositional processes, but the twentieth century saw considerable improvement in excavation and analytical techniques. The advent of modern dating and chronological methodologies offers very powerful tools for the analysis of cave fill deposits and this has resulted in the recognition of chronological incoherence in parts of some sites, with consequent re-evaluation of previous archaeological disputes. Obtaining multiple dates per context provides a means to assess the integrity and coherence of the archaeological and environmental records from cave fills. In the case of the Haua Fteah (Libya), this technique allowed the recognition of chronological coherence in low-energy depositional environments and limited recycling in high-energy contexts. We provide a conceptual model of the relationship between recycling, sedimentation rate and process energy. High-resolution investigation enables recognition of the complexity of the formation of cave sequences, thus an increasingly sophisticated understanding of human behaviour and environmental relationships in the past, and potentially gives a new life to old data
Involving community pharmacists in pharmacy practice research: experiences of peer interviewing
No full textBackground Translation of interest in research into active engagement of community pharmacists as research partners/co-researchers remains a challenge. Involving pharmacists in specific research techniques such as peer interviewing, however, may enhance validity of the results. Objective To enhance community pharmacists’ involvement in pharmacy practice research through peer interview training. Method A subgroup of participants in a multi-phase pharmacy practice research project trained to do peer interviews. These pharmacist interviewers attended a workshop and were mentored. Comments from their feedback forms and ongoing engagement with the Research Associate were thematically analysed. Results Positive themes from five interviewers included the importance of the topic and their wish to learn skills beyond their everyday role. The small group format of the training day helped to build confidence. Interviewers felt their shared professional background helped them to capture relevant comments and probe effectively. There were challenges, however, for interviewers to balance research activities with their daily work. Interviewers experienced difficulty in securing uninterrupted time with interviewees which sometimes affected data quality by ‘rushing’. Conclusion Community pharmacists can be engaged as peer interviewers to the benefit of the volunteers and research team, but must be well resourced and supported
Environmental Risk of Metal Mining Contaminated River Bank Sediment at Redox-Transitional Zones
No full textDiffuse metal pollution from mining impacted sediment is widely recognised as a potential source of contamination to river systems and may significantly hinder the achievement of European Union Water Framework Directive objectives. Redox-transitional zones that form along metal contaminated river banks as a result of flood and drought cycles could cause biogeochemical changes that alter the behaviour of polyvalent metals iron and manganese and anions such as sulphur. Trace metals are often partitioned with iron, manganese and sulphur minerals in mining-contaminated sediment, therefore the dissolution and precipitation of these minerals may influence the mobility of potentially toxic trace metals. Research indicates that freshly precipitated metal oxides and sulphides may be more “reactive” (more adsorbent and prone to dissolution when conditions change) than older crystalline forms. Fluctuations at the oxic-anoxic interface brought about through changes in the frequency and duration of flood and drought episodes may therefore influence the reactivity of secondary minerals that form in the sediment and the flux of dissolved trace metal release. UK climate change models predict longer dry periods for some regions, interspersed with higher magnitude flood events. If we are to fully comprehend the future environmental risk these climate change events pose to mining impacted river systems it is recommended that research efforts focus on identifying the primary controls on trace metal release at the oxic-anoxic interface for flood and drought cycles of different duration and frequency. This paper critically reviews the literature regarding biogeochemical processes that occur at different temporal scales during oxic,reducing and dry periods and focuses on how iron and sulphur based minerals may alter in form and reactivity and influence the mobility of trace metal contaminants. It is clear that
changes in redox potential can alter the composition of secondary iron and sulphur minerals and influence the sorption of toxic trace metals and susceptibility to dissolution when further redox potential changes occur. However further work is needed to determine:(i) The extent to which different duration and frequency of wet and dry cycles influences the dissolution and precipitation of iron and sulphur minerals in mining contaminated river
bank sediment; (ii) The temporal effects on mineral reactivity (sorption capacity and susceptibility to dissolution); (iii) The key biogeochemical processes that control the mobility of contaminant trace metals under these dynamic redox potential conditions
The ‘service – social benefit chain’ of a UK food cooperative.
No full textThe ‘service-profit chain’ model has proved to be of use for both analysing and improving the operations of private sector businesses. This model considers the profitability and growth of service organisations to be primarily the result of employee and customer loyalty. This research studied a community food cooperative, based in the North West UK. Thirteen semi-structured interviews were conducted with key informants connected to the cooperative. Data from the interviews were analysed using template analysis and an analytic generalisation approach to support, reject or modify the relationships in the service-profit chain model. As a result of this analysis a modified service-profit chain model appropriate for a food cooperative is proposed and discussed. This modified model has been named the ‘service-community benefit chain’. The value and limitations of the research are discussed. Further research involving a wider range of organisations and testing of the model is proposed
Testing Sunyaev-Zel'dovich measurements of the hot gas content of dark matter haloes using synthetic skies
No full textThe thermal Sunyaev-Zel'dovich (tSZ) effect offers a means of probing the hot gas in and around massive galaxies and galaxy groups and clusters, which is thought to constitute a large fraction of the baryon content of the Universe. The Planck collaboration recently performed a stacking analysis of a large sample of `locally brightest galaxies' (LBGs) and, surprisingly, inferred an approximately self-similar relation between the tSZ flux and halo mass. At face value, this implies that the hot gas mass fraction is independent of halo mass, a result which is in apparent conflict with resolved X-ray observations. We test the robustness of the inferred trend using synthetic tSZ maps generated from cosmological hydrodynamical simulations and using the same tools and assumptions applied in the Planck study. We show that, while the detection and the estimate of the `total' flux (within ) is reasonably robust, the inferred flux originating from within (i.e. the limiting radius to which X-ray observations typically probe) is highly sensitive to the assumed pressure distribution of the gas. Using our most realistic simulations with AGN feedback, that reproduce a wide variety of X-ray and optical properties of groups and clusters, we estimate that the derived tSZ flux within is biased high by up to to an order of magnitude for haloes with masses M. Moreover, we show that the AGN simulations are consistent with the total tSZ flux-mass relation observed with Planck, whereas a self-similar model is ruled out
An Innovative Approach for Improvement of Communications through Visual Schedule Model in Road Construction
No full textInnovative Visualisation Technologies applied to construction simulation and optimisation have the potential to improve communications and coordination amongst the construction team. In this context and in the drive for innovation in the construction management, a framework for automatic generation and visualisation of construction processes in road construction has been conceived, designed and developed. The framework is composed of road design data, quantities of cut and fill, productivity models, algorithms for modelling ground profiles and road profile visualiser. The paper details a Visual Schedule Model (VSM) that has been developed in the course of this research to realise the framework outlined above. The model is currently being evaluated using real life case study. Conclusions and future development have also been presented
The biogeography of abundant and rare bacterioplankton in the lakes and reservoirs of China.
No full textBacteria play key roles in the ecology of both aquatic and terrestrial ecosystems; however, little is known about their diversity and biogeography, especially in the rare microbial biosphere of inland freshwater ecosystems. Here we investigated aspects of the community ecology and geographical distribution of abundant and rare bacterioplankton using high-throughput sequencing and examined the relative influence of local environmental variables and regional (spatial) factors on their geographical distribution patterns in 42 lakes and reservoirs across China. Our results showed that the geographical patterns of abundant and rare bacterial subcommunities were generally similar, and both of them showed a significant distance-decay relationship. This suggests that the rare bacterial biosphere is not a random assembly, as some authors have assumed, and that its distribution is most likely subject to the same ecological processes that control abundant taxa. However, we identified some differences between the abundant and rare groups as both groups of bacteria showed a significant positive relationship between sites occupancy and abundance, but the abundant bacteria exhibited a weaker distance-decay relationship than the rare bacteria. Our results implied that rare subcommunities were mostly governed by local environmental variables, whereas the abundant subcommunities were mainly affected by regional factors. In addition, both local and regional variables that were significantly related to the spatial variation of abundant bacterial community composition were different to those of rare ones, suggesting that abundant and rare bacteria may have discrepant ecological niches and may play different roles in natural ecosystems
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