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The Hydrangea simulations: galaxy formation in and around massive clusters
No full textWe introduce the Hydrangea simulations, a suite of 24 cosmological hydrodynamic zoom-in simulations of massive galaxy clusters (M_200c = 10^14-10^15 M_Sun) with baryon particle masses of ~10^6 M_Sun. Designed to study the impact of the cluster environment on galaxy formation, they are a key part of the `Cluster-EAGLE' project (Barnes et al. 2017). They use a galaxy formation model developed for the EAGLE project, which has been shown to yield both realistic field galaxies and hot gas fractions of galaxy groups consistent with observations. The total stellar mass content of the simulated clusters agrees with observations, but central cluster galaxies are too massive, by up to 0.6 dex. Passive satellite fractions are higher than in the field, and at stellar masses Mstar > 10^10 M_Sun this environmental effect is quantitatively consistent with observations. The predicted satellite stellar mass function matches data from local cluster surveys. Normalized to total mass, there are fewer low-mass (Mstar 5r_200c). This is caused by a significantly increased stellar mass fraction of (sub-)haloes in the cluster environment, by up to ~0.3 dex even well beyond r_200c. Haloes near clusters are also more concentrated than equally massive field haloes, but these two effects are largely uncorrelated
Dispositional mindfulness and reward motivated eating: The role of emotion regulation and mental habit
Get PDFEvidence regarding the effectiveness of mindfulness based interventions (MBIs) for eating disorders, weight management and food craving is emerging and further studies are required to understand the underlying mechanisms of MBIs in these domains. The current study was designed to establish the role of specific mechanisms underlying the putative relationship between mindfulness and reward motivated eating. We predicted that mindfulness would be negatively related to features of reward motivated eating and that this association would be mediated by emotion regulation and habitual negative self-thinking. A cross-sectional survey measuring uncontrolled and emotional eating, mindfulness, emotion regulation and habitual negative self-thinking was completed by female and male meditators and non-meditators (N = 632). Lower levels of dispositional mindfulness were associated with difficulties in emotion regulation, habitual negative self-thinking and both emotional and uncontrolled eating. Difficulties in emotion regulation significantly mediated the mindfulness-uncontrolled eating relationship. Habitual negative self-thinking significantly mediated the mindfulness-emotional eating relationship. Participants with meditation experience reported greater levels of dispositional mindfulness, fewer difficulties with emotion regulation and habitual negative self-thinking and reduced uncontrolled eating tendencies, compared to non-meditators. The findings suggest that MBIs designed to change reward motivated eating and weight control should focus on emotion regulation and mental habits as underlying mechanisms
Low levels of hepatitis C diagnosis and testing uptake among people who inject image and performance enhancing drugs in England and Wales, 2012-15
Get PDFPeople injecting image and performance enhancing drugs (IPEDs) have traditionally not been perceived as being at high risk of hepatitis C virus (HCV) infection. However, recent studies indicate the HCV antibody (anti-HCV) prevalence in this group is 10-times that in the general population. HCV testing uptake and undiagnosed infections are examined using data from a voluntary unlinked-anonymous survey. Method People injecting IPEDs across England and Wales completed a short bio-behavioural survey (2012–15). Anti-HCV status and self-reports of HCV testing were used in the analysis. Results The participants median age was 31 years, 98% were men, 14% had also injected psychoactive drugs and the anti-HCV prevalence was 4.8% (N = 564). Among those who had never injected psychoactive drugs the anti-HCV prevalence was 1.4%; among those who had recently injected psychoactive drugs (preceding 12 months) prevalence was 39% and among those who had done this previously 14% (p < 0.001). Overall, 37% had been tested for HCV: among those who had recently injected psychoactive drugs 78% had been tested, as had 56% of those who had injected psychoactive drugs previously; 33% of those never injecting psychoactive drugs were tested (p < 0.001). Overall, 44% of those with anti-HCV were aware of this; however, only 14% of those who had never injected psychoactive drugs were aware. Conclusions One-in-twenty people who inject IPEDs have anti-HCV. HCV infections among those who had never injected psychoactive drugs were mostly undiagnosed, though this group had a lower prevalence. Targeted HCV testing interventions are also needed for those injecting IPEDs
Inter-decadal variability in potential glacier surface melt energy at Vestari Hagafellsjökull (Langjökull, Iceland) and the role of synoptic circulation
No full textThe surface energy balance (SEB) of glaciers, although of considerable importance for understanding the melt response to climate change, is rarely analysed for more than a few melt seasons due to the logistical challenges of meteorological measurement campaigns on glaciers. Insight into low-frequency (inter-decadal) changes in the SEB in response to climate warming and variable atmospheric circulation patterns has thus been limited. Here this problem is addressed by using ERA-Interim reanalysis data to extend glacier-meteorological records at two locations on Vestari Hagafellsjökull (Iceland) for the period 1979–2012. Trend analysis is conducted for this series before the role of synoptic circulation in modulating surface energetics is investigated. The results indicate that potential melt energy has increased significantly throughout the period of simulation at both locations (by 19.7 and 32.4%), with the largest increase evident for the turbulent heat fluxes (36.3 and 93.1%). The synoptic conditions associated with the recent high melt rates on the proximate Greenland Ice Sheet (GrIS) do not result in similarly extreme melt conditions for our Icelandic location. We also find that the North Atlantic Oscillation Index is significantly correlated with the radiative and latent heat components of the SEB. This association remains hidden if the melt rate is assessed in isolation, highlighting the utility of the SEB approach presented here for assessing synoptic aspects of glacier-climate interactions
Vitamin D deficiency: awareness and practice
Get PDFWithin the UK rickets is emerging as a national public health issue, particularly among at-risk groups. There is concern that health professionals are overlooking recommendations for vitamin supplementation and opportunities for prevention. This paper reports on a study that aimed to identify current knowledge and practice regarding vitamin D deficiency and supplementation
among community midwifery and health visiting teams employed in one NHS trust. A questionnaire was distributed to all health visiting and community midwifery team members (n=96), with a 76% response rate (n=73). Results suggest varying levels of awareness about vitamin
D deficiency and groups at increased risk. Only 52% reported that they were aware of health department recommendations for vitamin supplementation. Health visiting teams recommended supplements more frequently than community midwives, but overall the recommendations were implemented inconsistently. Participants identified families eligible for the government Healthy Start scheme, but fewer were recommending Healthy Start vitamins. A deeper understanding of vitamin D deficiency and health department recommendations for
vitamin supplementation is required by health professionals to ensure families are advised about appropriate prevention messages and to implement recommendations effectively.
Key words: Vitamin D deficiency, rickets, Healthy Start,
vitamin supplements, health departmen
Dark matter halo properties of GAMA galaxy groups from 100 square degrees of KiDS weak lensing data
No full textThe Kilo-Degree Survey (KiDS) is an optical wide-field survey designed to map the matter distribution in the Universe using weak gravitational lensing. In this paper, we use these data to measure the density profiles and masses of a sample of spectroscopically identified galaxy groups and clusters from the Galaxy And Mass Assembly (GAMA) survey. We detect a highly significant signal (signal-to-noise-ratio 120), allowing us to study the properties of dark matter haloes over one and a half order of magnitude in mass, from . We interpret the results for various subsamples of groups using a halo model framework which accounts for the mis-centring of the Brightest Cluster Galaxy (used as the tracer of the group centre) with respect to the centre of the group's dark matter halo. We find that the density profiles of the haloes are well described by an NFW profile with concentrations that agree with predictions from numerical simulations. In addition, we constrain scaling relations between the mass and a number of observable group properties. We find that the mass scales with the total r-band luminosity as a power-law with slope (1-sigma) and with the group velocity dispersion as a power-law with slope (1-sigma). Finally, we demonstrate the potential of weak lensing studies of groups to discriminate between models of baryonic feedback at group scales by comparing our results with the predictions from the Cosmo-OverWhelmingly Large Simulations (Cosmo-OWLS) project, ruling out models without AGN feedback
Chemical determinants of occupational hypersensitivity pneumonitis
No full textBackground: Workplace inhalational exposures to low molecular weight (LMW) chemicals cause hypersensitivity pneumonitis (HP) as well as the more common manifestation of respiratory hypersensitivity, occupational asthma (OA).
Aims: To explore whether chemical causation of HP is associated with different structural and physico-chemical determinants from OA.
Methods: Chemical causes of human cases of HP and OA were identified from searches of peer-reviewed literature up to the end of 2011. Each chemical was categorised according to whether or not it had been the attributed cause of at least one case of HP. The predicted asthma hazard was determined for each chemical using a previously developed quantitative structure-activity relationship (QSAR) model. The chemicals in both sets were independently and ‘blindly’ analysed by an expert in mechanistic chemistry for a qualitative prediction of protein cross-linking potential and determination of lipophilicity (log Kow).
Results: Ten HP causing chemicals were identified and had a higher median QSAR predicted asthma hazard than the control group of 101 OA causing chemicals (p < 0.005). Nine of ten HP causing chemicals were predicted to be protein cross-linkers compared to 24/92 controls (p<0.0001). The distributions of log Kow indicated higher values for the HP list (median 3.47) compared to controls (median 0.81) (p < 0.05).
Conclusion: These findings suggest that chemicals capable of causing HP tend to have higher predicted asthma hazard, are more lipophilic and are more likely to be protein cross-linkers than those causing OA.
Key words: hypersensitivity pneumonitis, occupational chemicals, occupational respiratory disease, toxic inhalatio
Prediction of Preterm Deliveries from EHG Signals Using Machine Learning
No full textThere has been some improvement in the treatment of preterm infants, which has helped to increase their chance of survival. However, the rate of premature births is still globally increasing. As a result, this group of infants are most at risk of developing severe medical conditions that can affect the respiratory, gastrointestinal, immune, central nervous, auditory and visual systems. In extreme cases, this can also lead to long-term conditions, such as cerebral palsy, mental retardation, learning difficulties, including poor health and growth. In the US alone, the societal and economic cost of preterm births, in 2005, was estimated to be $26.2 billion, per annum. In the UK, this value was close to £2.95 billion, in 2009. Many believe that a better understanding of why preterm births occur, and a strategic focus on prevention, will help to improve the health of children and reduce healthcare costs. At present, most methods of preterm birth prediction are subjective. However, a strong body of evidence suggests the analysis of uterine electrical signals (Electrohysterography), could provide a viable way of diagnosing true labour and predict preterm deliveries. Most Electrohysterography studies focus on true labour detection during the final seven days, before labour. The challenge is to utilise Electrohysterography techniques to predict preterm delivery earlier in the pregnancy. This paper explores this idea further and presents a supervised machine learning approach that classifies term and preterm records, using an open source dataset containing 300 records (38 preterm and 262 term). The synthetic minority oversampling technique is used to oversample the minority preterm class, and cross validation techniques, are used to evaluate the dataset against other similar studies. Our approach shows an improvement on existing studies with 96% sensitivity, 90% specificity, and a 95% area under the curve value with 8% global error using the polynomial classifier
Analytical Formulas for Phase Voltage RMS Squared and THD in PWM Multiphase Systems
Get PDFThe analysis and assessment of the pulsewidth modulation (PWM) techniques is commonly based on the comparison of the total harmonic distortion (THD) results. THD is usually calculated by application of the Fourier transformation and by taking a limited number of harmonics into the consideration. In this paper, derivation of analytical formulas for the phase voltage THD is presented. The considered system is a symmetrical multiphase starconnected load, supplied from a multilevel pulsewidth-modulated voltage-source inverter (VSI, three-phase case is also covered). The solution is based on the Parseval’s theorem, which links frequency spectrum and time domain through the average power (i.e., rootmean- square (rms) squared value) of the signal. The assumption throughout the derivations is that the ratio of the switching to fundamental frequency is high. Derivations are based on the integration of the power of the PWM signal in a single switching period over the fundamental period of the signal. Only ideal sinusoidal reference voltages are analyzed, and no injection of any type is considered. Formulas for phase voltage THD for any number of phases are derived for two- and three-level cases, for themost commonly used carrier-based methods. Comparison of the analytically obtained curves with simulation and experimental results shows a high level of agreement and validates the analysis and derivations
Galaxy And Mass Assembly (GAMA): deconstructing bimodality - I. Red ones and blue ones
No full textWe measure the mass functions for generically red and blue galaxies, using a z 8:7 field galaxies from the Galaxy And Mass Assembly (GAMA) survey. Our motivation is that, as we show, the dominant uncertainty in existing measurements stems from how ‘red’ and ‘blue’ galaxies have been selected/defined. Accordingly, we model our data as two naturally overlapping populations, each with their own mass function and colour–mass relation, which enables us characterise the two populations without having to specify a priori which galaxies are ‘red’ and ‘blue’. Our results then provide the means to derive objective operational definitions for the terms ‘red’ and ‘blue’, which are based on the phenomenology of the colour–mass diagrams. Informed by this descriptive modelling, we show that: 1.) after accounting for dust, the stellar colours of ‘blue’ galaxies do not depend strongly on mass; 2.) the tight, flat ‘dead sequence’ does not extend much below logM_ _ 10:5; instead, 3.) the stellar colours of ‘red’ galaxies vary rather strongly with mass, such that lower mass ‘red’ galaxies have bluer stellar populations; 4.) below logM_ _ 9:3, the ‘red’ population dissolves into obscurity, and it becomes problematic to talk about two distinct populations; as a consequence, 5.) it is hard to meaningfully constrain the shape, including the existence of an upturn, of the ‘red’ galaxy mass function below logM_ _ 9:3. Points 1–4 provide meaningful targets for models, of galaxy formation and evolution to aim for
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