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De la fenomenología de la voluntad al primado de la persona en la acción. A. Pfänder y L. Polo
Get PDFTanto Pfänder como Polo han hecho unos estudios dignos
de mención en lo que a la ética se refiere. Queremos rescatar en este breve trabajo lo mejor de estos pensadores que desde perspectivas y métodos
muy dispares abordan temas y resuelven problemas de modos muy distintos
llevándonos, cada uno a su manera, al puerto seguro del ser personal. Dichos pensadores nos muestran que, tanto con el método de la fenomenología
realista como con el método poliano del abandono de la presencia, se puede entrever e incluso fundamentar el primado del ser personal en la acción
humana.Pfänder and Polo both have carried out studies that are
worth mentioning with regard to ethics. In this brief work we would like
to rescue what is best in these two thinkers who, from rather disparate
perspectives and methods, confront topics and resolve problems in rather distinct ways to carry us to the safe port of personal being, each in
his own manner. These two thinkers show us that it is possible to entertain
and even support the primacy of personal being in human action, using
the method of realistic phenomenology or the polianic abandonment
of presence
Fichas de buenas prácticas para la atención a problemas de salud mental en Educación Primaria. Una herramienta de ayuda para los centros educativos. Ficha individual: Trastorno obsesivo compulsivo
No full textMaterial elaborado en el marco del proyecto de investigación orientado a la transferencia del conocimiento,
"Revisión y valoración de políticas de prevención e intervención en salud mental infanto-juvenil
en centros educativos” (IP, Martiño Rodríguez-González, ICS-UNAV) desarrollado por la Universidad
de Navarra en colaboración con la Universidad Internacional de La Rioja UNIR- ITEI.
Esta guía pretende proporcionar al profesorado un marco de comprensión sencillo acerca de los problemas de salud mental en la etapa de primaria, así como identificar señales de alarma y ofrecer pautas para un primer abordaje con los estudiantes que puedan estar experimentando tales problemas. La guía busca promover y prevenir la salud mental, pero en ningún diagnosticar u orientar sobre la forma de intervenir. El objetivo de este documento es prevenir y detectar los problemas de salud mental, además de planificar el acompañamiento, cuidado y, en caso necesario, derivación a los servicios especializados de salud mental. Ayudar al alumno es, en gran medida, conseguir coordinarse y colaborar con las familias y otros profesionales externos al centro educativo. Para cada una de las fichas incluidas en este documento, se sigue la misma estructura: primero, una introducción sobre el problema de salud mental o el trastorno en cuestión; segundo, se detallan las principales señales de alarma que pueden ser observadas por el docente en diferentes espacios y situaciones escolares; finalmente, se proporcionan sugerencias sobre su abordaje, ¿qué puede hacer el maestro o profesor ante esto
Scandal, synergy, and sexism: Three essays on decision-making dynamics in the organization context
No full textThis dissertation navigates the intricate landscape of decision-making within
organizational contexts, shedding light on the complexities inherent in three distinct yet
interrelated areas: corporate scandals, ecosystem investments, and sexism attributions. In this
dissertation, I take the opportunity to study interesting questions within this domain through
the lens of Organizational Behavior and Decision Science. In chapter 1, I investigate the
intriguing phenomenon where certain corporate scandals not only fail to erode reputation but
lead to increased public support. Drawing on concepts of rivalry, schadenfreude, and moral
disengagement, I explore the psychological conditions underpinning public reactions to
scandals. In chapter 2, I explore critical factors influencing risk calibration, such as the
representation of chances in terms of frequencies and framing risky components as completed
in the past. This paper challenges prevailing notions of risk perception in interdependent
contexts. In chapter 3, I delve into the intersection of sexism and rudeness, challenging the
concept of an “equal opportunity defense”. I explore how rudeness towards men complicates
sexism attributions and unexpectedly amplifies punishment. Methodologically, I primarily
utilize experimental methods to establish causal relationships. In sum, these three papers
contribute to our understanding of decision dynamics in organizational contexts, offering
nuanced insights into scandal management, risk perception in investments, and the complex
interplay of rudeness and sexism attributions
Revisión y valoración de políticas de prevención e intervención en salud mental infanto-juvenil en centros educativos. Informe técnico: Estados Unidos, Reino Unido y España
No full textEn el marco del Proyecto de investigación orientado a la transferencia del conocimiento, "Revisión y valoración de políticas de prevención e intervención en salud mental infanto-juvenil en centros educativos” (IP, Martiño Rodríguez-González, ICS-UNAV) desarrollado en colaboración con la Universidad Internacional de La Rioja (UNIR- ITEI), se ha generado el presente Informe técnico con el objetivo de explorar cómo se están abordando la promoción del bienestar emocional y las dificultades en salud mental en el contexto educativo (con niños y adolescentes), en Estados Unidos, Reino Unido y España. Los primeros dos, son países de referencia, los cuales han trabajado sistemáticamente en la incorporación de la educación emocional en sus currículos escolares, así como, en el diseño y validación de programas de bienestar emocional y prevención de los problemas de salud mental en el alumnado
Ibáñez-Martín, J. A. y Naval, C. (Eds.) (2022). Retos actuales de la acción educativa. Carácter y personalidad. Madrid, Narcea, 157 pp. [RECENSIÓN]
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Co-occurrence of mutations in NF1 and other susceptibility genes in pheochromocytoma and paraganglioma
No full textIntroductionThe percentage of patients diagnosed with pheochromocytoma and paraganglioma (altogether PPGL) carrying known germline mutations in one of the over fifteen susceptibility genes identified to date has dramatically increased during the last two decades, accounting for up to 35-40% of PPGL patients. Moreover, the application of NGS to the diagnosis of PPGL detects unexpected co-occurrences of pathogenic allelic variants in different susceptibility genes. MethodsHerein we uncover several cases with dual mutations in NF1 and other PPGL genes by targeted sequencing. We studied the molecular characteristics of the tumours with co-occurrent mutations, using omic tools to gain insight into the role of these events in tumour development. ResultsAmongst 23 patients carrying germline NF1 mutations, targeted sequencing revealed additional pathogenic germline variants in DLST (n=1) and MDH2 (n=2), and two somatic mutations in H3-3A and PRKAR1A. Three additional patients, with somatic mutations in NF1 were found carrying germline pathogenic mutations in SDHB or DLST, and a somatic truncating mutation in ATRX. Two of the cases with dual germline mutations showed multiple pheochromocytomas or extra-adrenal paragangliomas - an extremely rare clinical finding in NF1 patients. Transcriptional and methylation profiling and metabolite assessment showed an intermediate signature to suggest that both variants had a pathological role in tumour development. DiscussionIn conclusion, mutations affecting genes involved in different pathways (pseudohypoxic and receptor tyrosine kinase signalling) co-occurring in the same patient could provide a selective advantage for the development of PPGL, and explain the variable expressivity and incomplete penetrance observed in some patients
More than 2% of circulating tumor plasma cells defines plasma cell leukemia-like multiple myeloma
No full textPURPOSE Primary plasma cell leukemia (PCL) is the most aggressive monoclonal gammopathy. It was formerly
characterized by 5%.
We hypothesized that primary PCL is not a separate clinical entity, but rather that it represents ultra-high-risk
multiple myeloma (MM) characterized by elevated CTC levels.
METHODS We assessed the levels of CTCs by multiparameter flow cytometry in 395 patients with newly diagnosed transplant-ineligible MM to establish a cutoff for CTCs that identifies the patients with ultra-high-risk
PCL-like MM. We tested the cutoff on 185 transplant-eligible patients with MM and further validated on an
independent cohort of 280 transplant-ineligible patients treated in the GEM-CLARIDEX trial. The largest
published real-world cohort of patients with primary PCL was used for comparison of survival. Finally, we
challenged the current 5% threshold for primary PCL diagnosis.
RESULTS Newly diagnosed transplant-ineligible patients with MM with 2%-20% CTCs had significantly shorter
progression-free survival (3.1 v 15.6 months; P , .001) and overall survival (14.6 v 33.6 months; P 5 .023) than
patients with , 2%. The 2% cutoff proved to be applicable also in transplant-eligible patients with MM and was
successfully validated on an independent cohort of patients from the GEM-CLARIDEX trial. Most importantly,
patients with 2%-20% CTCs had comparable dismal outcomes with primary PCL. Moreover, after revealing a low
mean difference between flow cytometric and morphologic evaluation of CTCs, we showed that patients with
2%-5% CTCs have similar outcomes as those with 5%-20% CTCs.
CONCLUSION Our study uncovers that $ 2% CTCs is a biomarker of hidden primary PCL and supports the
assessment of CTCs by flow cytometry during the diagnostic workup of MM
Biallelic TET2 mutations confer sensitivity to 5 '-azacitidine in acute myeloid leukemia
Get PDFPrecision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient with acute myeloid leukemia (AML) that was chemoresistant to anthracycline and cytarabine but acutely sensitive to 5 '-azacitidine (5 '-Aza) hypomethylating monotherapy, resulting in long-term morphological remission. Given the role of TET2 as a regulator of genomic methylation, we hypothesized that mutant TET2 allele dosage affects response to 5 '-Aza. Using an isogenic cell model system and an orthotopic mouse xenograft, we demonstrate that biallelic TET2 mutations confer sensitivity to 5 '-Aza compared with cells with monoallelic mutations. Our data argue in favor of using hypomethylating agents for chemoresistant disease or as first-line therapy in patients with biallelic TET2-mutated AML and demonstrate the importance of considering mutant allele dosage in the implementation of precision medicine for patients with cancer
On the dynamics of a liquid bridge between a sphere and a vertically vibrated solid surface
Get PDFThis work presents an experimental study of the response of a liquid bridge formed between a sphere and a plane solid surface subjected to a vertical sinusoidal vibration. The amplitude and frequency of the oscillations can be varied. The successive movement of the particle along with the bridge deformation is registered to follow the dynamics of the system. The motivation is to figure out how capillary and viscosity forces can be modeled with the help of the experimental data obtained and to settle down a simplified theoretical approach capable of being implemented in the description of many phenomena involving wet granular grains. The results indicate that the viscosity effects can be neglected as soon as the amplitude of the movement is not too small, still obtaining a reasonable description of the dynamical behavior of the sphere/liquid-bridge system