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Grapevine varieties show different sensitivities to flavonoid alterations caused by high temperatures under two irrigation conditions
No full textThis study aimed to assess the response of four red grapevine (Vitis vinifera L.) varieties to elevated temperature,
drought and their combination, focusing on the concentration and profile of grape flavonoids. Fruit-bearing
cuttings of Tempranillo, Cabernet Sauvignon, Merlot and Grenache grew in greenhouses under, either
ambient temperature (T) or ambient temperature + 4 ◦C (T+4). Plants also received either full irrigation (FI,
substrate field capacity) or deficit irrigation (DI, 50 % substrate field capacity). In general, T+4 decreased the
concentration of anthocyanins, but DI mitigated this effect. T+4 and DI increased the abundance of methylated
anthocyanins and flavonols with additive effects. Grapes under T+4 had higher abundance of acylated anthocyanins, while DI increased the proportion of tri-hydroxylated anthocyanins and flavonols. The impact of
interacting elevated temperature and drought on grape composition was genotype dependent. In terms of
anthocyanin concentration and profile, Tempranillo was the most affected variety, whereas Grenache was less
sensitive
Bilobed-modified cervicofacial flap for reconstruction of an extensive surgical defect of the cheek
No full textLarge surgical defects of the cheek represent a reconstructive challenge due to its important role in facial expression
and aesthetics. One of the most effective options is the
cervicofacial flap (CF), which uses a random advancement
and rotation flap technique based on the skin laxity of the
cheek, preauricular region, and neck. Modifications extending to the chest when necessary have been documented.
However, the size and location of defects are variable, sometimes too large to be reconstructed with the conventional
CF flap. In this case report we present a solution to close
such defects by design modification
Fichas de buenas prácticas para la atención a problemas de salud mental en Educación Primaria. Una herramienta de ayuda para los centros educativos
No full textMaterial elaborado en el marco del proyecto de investigación orientado a la transferencia del conocimiento,
"Revisión y valoración de políticas de prevención e intervención en salud mental infanto-juvenil
en centros educativos” (IP, Martiño Rodríguez-González, ICS-UNAV) desarrollado por la Universidad
de Navarra en colaboración con la Universidad Internacional de La Rioja UNIR- ITEI. Esta guía pretende proporcionar al profesorado un marco de comprensión sencillo acerca de los problemas de salud mental en la etapa de primaria, así como identificar señales de alarma y ofrecer pautas para un primer abordaje con los estudiantes que puedan estar experimentando tales problemas. La guía busca promover y prevenir la salud mental, pero en ningún diagnosticar u orientar sobre la forma de intervenir. El objetivo de este documento es prevenir y detectar los problemas de salud mental, además de planificar el acompañamiento, cuidado y, en caso necesario, derivación a los servicios especializados de salud mental. Ayudar al alumno es, en gran medida, conseguir coordinarse y colaborar con las familias y otros profesionales externos al centro educativo. Para cada una de las fichas incluidas en este documento, se sigue la misma estructura: primero, una introducción sobre el problema de salud mental o el trastorno en cuestión; segundo, se detallan las principales señales de alarma que pueden ser observadas por el docente en diferentes espacios y situaciones escolares; finalmente, se proporcionan sugerencias sobre su abordaje, ¿qué puede hacer el maestro o profesor ante esto
Natural antioxidants (rosemary and parsley) in microwaved ground meat patties: effects of in vitro digestion
No full textBackground: Minimizing food oxidation remains a challenge in several environments. The addition of rosemary extract (150 mg kg-1) and lyophilized parsley (7.1 g kg-1) at equivalent antioxidant activity (5550 μg Trolox equivalents kg-1) to meat patties was assessed in terms of their effect during microwave cooking and after being subjected to an in vitro digestion process.
Results: Regardless of the use of antioxidants, cooking caused a decrease of the fat content as compared to raw samples, without noticing statistical differences in the fatty acid distribution between raw and cooked samples [44%, 47% and 6.8%, of saturated fatty acid (SFA), monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA), respectively]. However, the bioaccessible lipid fraction obtained after digestion was less saturated (around 34% SFA) and more unsaturated (35% MUFA +30% PUFA). Cooking caused, in all types of samples, an increased lipid [thiobarbituric acid reactive substances (TBARS)] and protein (carbonyls) oxidation values. The increase of TBARS during in vitro digestion was around 7 mg malondialdehyde (MDA) kg-1 for control and samples with parsley and 4.8 mg MDA kg-1 with rosemary. The addition of parsley, and particularly of rosemary, significantly increased the antioxidant activity (DPPH) of cooked and digested microwaved meat patties.
Conclusion: Whereas rosemary was effective in minimizing protein oxidation during cooking and digestion as compared to control samples, parsley could only limit it during digestion. Lipid oxidation was only limited by rosemary during in vitro digestion. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry
Decision-making for community resilience: A review of decision support systems and their applications
No full textDecision Support Systems (DSS) have emerged as important tools for enhancing community resilience due to their ability to provide timely and efficient solutions to disaster-related problems while reflecting the perspectives of different stakeholders and utilizing multiple data sources. This paper provides a comprehensive summary of DSS applications to community resilience, emphasizing how the different modeling techniques are used in different disaster phases. We found that optimization techniques are the most frequently used methods for building DSS. Furthermore, we found that DSS tend to focus more on the preparedness and response phases of disaster management, rather than the recovery and mitigation phases. Moreover, the study highlights the main challenges in developing and implementing DSS for resilience, such as data availability, the uncertainty of the disaster context, and the need for cross-disciplinary collaboration. Based on the reviewed papers, we provide some guidelines to practitioners to select the most suitable decision-support tools for the needs of their community. The study aims to help decision-makers and researchers build effective decision support systems for enhancing community resilience, considering the current challenges
A means of managerial expression: Why ideology matters for management
No full textIn this dissertation, I outline the intellectual history of ideology research within management and organizational studies then attempt to integrate previous theorizing around group interests to explore the effects of owner ideology on organizations around issues of race. The first chapter is a combination integrative review an hermeneutic study of the current dominant research stream on ideology In the second chapter, using an institutionally-created position from the National Basketball Association (NBA) – the “14th/15th player” slots that derive from requirements that all teams have no more than 15 players on their rosters but can only play 13 of them per game – my coauthors and I examinee how owner political ideology of privately held organizations interacts with race to yield preferential hiring/retention. Utilizing daily game data from NBA players from the 2000-2001 through 2019-2020 seasons, we find that White U.S. players face a hazard over 120 times greater than non-White U.S. players of being acquired as “14th/15th players” when the acquiring team’s owner is maximally conservative and that those same players face a hazard 96% lower when the owner is maximally liberal. We contend that these 14th/15th players can serve as sinecures for conservatives – i.e., “flexible offices with pay but few if any fixed duties” – allowing for differential hiring/retention treatment of White players based on ideology.
The last chapter attempts to restore the occasionally dormant theoretical conservation between ideology and social movements by looking at the role of mega-threats in motivating platform activist responses to organizational owner actions. Using (née) Twitter data from National Basketball Association (NBA) and Women’s National Basketball Association (WNBA) players, we find utilizing a triple-difference estimator that a strategic, solitary tweet by a WNBA player had a 72% impact on in-state versus out-of-state political donations, offering a quantifiable estimate of how platform activists oppose certain organizational owners as a product of conflicting ideologies. Rather than treating ideology as separate from activism, we hope that these findings will push management and organizational scholars to understand how group attributes such as class that might inspire Top Management Team (TMT) ideological action going forward
Disentangling anti-tumor response of immunotherapy combinations: a physiologically based framework for V937 oncolytic virus and Pembrolizumab
No full textImmuno-oncology (IO) is a growing strategy in cancer treatment. Oncolytic viruses (OVs) can selectively infect cancer cells and lead to direct and/or immune-dependent tumor lysis. This approach represents an opportunity to potentiate the efficacy of immune checkpoint inhibitors (ICI), such as pembrolizumab. Currently, there is a lack of comprehensive quantitative models for the aforementioned scenarios. In this work, we developed a mechanistic framework describing viral kinetics, viral dynamics, and tumor response after intratumoral (i.t.) or intravenous (i.v.) administration of V937 alone or in combination with pembrolizumab. The model accounts for tumor shrinkage, in both injected and non-injected lesions, induced by: viral-infected tumor cell death and activated CD8 cells. OV-infected tumor cells enhanced the expansion of CD8 cells, whereas pembrolizumab inhibits their exhaustion by competing with PD-L1 in their binding to PD-1. Circulating viral levels and treatment effects on tumor volume were adequately characterized in all the different scenarios. This mechanistic-based model has been developed by combining top-down and bottom-up approaches and provides individual estimates of viral and ICI responses. The robustness of the model is reflected by the description of the tumor size time profiles in a variety of clinical scenarios. Additionally, this platform allows us to investigate not only the contribution of processes related to the viral kinetics and dynamics on tumor response, but also the influence of its interaction with an ICI. Additionally, the model can be used to explore different scenarios aiming to optimize treatment combinations and support clinical development
The profile of social communication in Dravet syndrome
No full textDravet syndrome (DS) presents a multifaceted clinical picture marked by epilepsy, cognitive impairments and
behavioral disorders that progresses throughout development. Behavioral disorders include impairments in social relationships and communication, with frequent diagnosis of autism spectrum disorder. This study focused on comprehensively evaluating and comparing social communication profiles among a group of 43 children with Dravet syndrome, 30 children with level 1 autism spectrum disorder, 36 with social (pragmatic) communication disorder, and 18 with intellectual disability. Using validated tools like the Childhood Autism Spectrum Test and Children’s Communication Checklist, distinct patterns of social communication deficits were delineated. Our findings indicate that children with Dravet syndrome experience challenges in social relationships, primarily due to difficulties in use of pragmatic language. Areas such as range of interests and social interaction are less affected compared to those with ASD, emphasizing differing profiles between the conditions. While children with DS and ID may have similar intellectual functioning, the different social communication deficits in DS indicate their role in the DS phenotype beyond ID. These results underscore the unique social communication profile of DS and emphasizes the importance of tailored interventions and deep phenotyping efforts for effective DS management
Improving the reliability of a future more electric aircraft DC power system through a novel topology and software combination.
No full textThe More Electric Aircraft concept has arisen in an attempt to achieve the goals stated by different international organisations in terms of the concept of future aircraft. While some of these requirements are related to reducing the negative effects of airfreight such as CO2 emissions or fuel consumption, other requirements focus on aircraft safety enhancement. Nevertheless, if the way to achieve the vast majority of these goals is based on increasing electrification level of aircrafts, then their electric power system must be reviewed and reconsidered. Currently, literature proposes device redundancy as the main option for meeting aircraft safety requirements. This paper proposes alternative architecture, which consists of merging a new source code and recently developed topology, which makes it possible to decentralise the aircraft's DC bus, in order to increase its safety and meet the stated goals. While the new topology has been validated through small-scale prototyping, proposed software strategy has been validated in a virtual environment using simulations. The architecture developed enables a path to be selected in the electric power system: examining different options in the system, analysing which of those options are the most efficient and, finally, sending signals to configure the power system connections to power the load. Based on the results of those tests, the alternative proposed satisfactorily powers selected loads